Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity

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Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity. / van der Spoel, Evie; Jansen, Steffy W; Akintola, Abimbola A; Ballieux, Bart E; Cobbaert, Christa M; Slagboom, P Eline; Blauw, Gerard Jan; Westendorp, Rudi G J; Pijl, Hanno; Roelfsema, Ferdinand; van Heemst, Diana.

In: Aging Cell, Vol. 15, No. 6, 12.2016, p. 1126–1131.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

van der Spoel, E, Jansen, SW, Akintola, AA, Ballieux, BE, Cobbaert, CM, Slagboom, PE, Blauw, GJ, Westendorp, RGJ, Pijl, H, Roelfsema, F & van Heemst, D 2016, 'Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity', Aging Cell, vol. 15, no. 6, pp. 1126–1131. https://doi.org/10.1111/acel.12519

APA

van der Spoel, E., Jansen, S. W., Akintola, A. A., Ballieux, B. E., Cobbaert, C. M., Slagboom, P. E., ... van Heemst, D. (2016). Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity. Aging Cell, 15(6), 1126–1131. https://doi.org/10.1111/acel.12519

Vancouver

van der Spoel E, Jansen SW, Akintola AA, Ballieux BE, Cobbaert CM, Slagboom PE et al. Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity. Aging Cell. 2016 Dec;15(6):1126–1131. https://doi.org/10.1111/acel.12519

Author

van der Spoel, Evie ; Jansen, Steffy W ; Akintola, Abimbola A ; Ballieux, Bart E ; Cobbaert, Christa M ; Slagboom, P Eline ; Blauw, Gerard Jan ; Westendorp, Rudi G J ; Pijl, Hanno ; Roelfsema, Ferdinand ; van Heemst, Diana. / Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity. In: Aging Cell. 2016 ; Vol. 15, No. 6. pp. 1126–1131.

Bibtex

@article{0df9e5c91e1b4d3986a5fb6ce0a692fe,
title = "Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity",
abstract = "Reduced growth hormone (GH) signaling has been consistently associated with increased health and lifespan in various mouse models. Here, we assessed GH secretion and its control in relation with human familial longevity. We frequently sampled blood over 24 h in 19 middle-aged offspring of long-living families from the Leiden Longevity Study together with 18 of their partners as controls. Circulating GH concentrations were measured every 10 min and insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP3) every 4 h. Using deconvolution analysis, we found that 24-h total GH secretion was 28{\%} lower (P = 0.04) in offspring [172 (128-216) mU L(-1) ] compared with controls [238 (193-284) mU L(-1) ]. We used approximate entropy (ApEn) to quantify the strength of feedback/feedforward control of GH secretion. ApEn was lower (P = 0.001) in offspring [0.45 (0.39-0.53)] compared with controls [0.66 (0.56-0.77)], indicating tighter control of GH secretion. No significant differences were observed in circulating levels of IGF-1 and IGFBP3 between offspring and controls. In conclusion, GH secretion in human familial longevity is characterized by diminished secretion rate and more tight control. These data imply that the highly conserved GH signaling pathway, which has been linked to longevity in animal models, is also associated with human longevity.",
author = "{van der Spoel}, Evie and Jansen, {Steffy W} and Akintola, {Abimbola A} and Ballieux, {Bart E} and Cobbaert, {Christa M} and Slagboom, {P Eline} and Blauw, {Gerard Jan} and Westendorp, {Rudi G J} and Hanno Pijl and Ferdinand Roelfsema and {van Heemst}, Diana",
note = "{\circledC} 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.",
year = "2016",
month = "12",
doi = "10.1111/acel.12519",
language = "English",
volume = "15",
pages = "1126–1131",
journal = "Aging Cell",
issn = "1474-9718",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity

AU - van der Spoel, Evie

AU - Jansen, Steffy W

AU - Akintola, Abimbola A

AU - Ballieux, Bart E

AU - Cobbaert, Christa M

AU - Slagboom, P Eline

AU - Blauw, Gerard Jan

AU - Westendorp, Rudi G J

AU - Pijl, Hanno

AU - Roelfsema, Ferdinand

AU - van Heemst, Diana

N1 - © 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

PY - 2016/12

Y1 - 2016/12

N2 - Reduced growth hormone (GH) signaling has been consistently associated with increased health and lifespan in various mouse models. Here, we assessed GH secretion and its control in relation with human familial longevity. We frequently sampled blood over 24 h in 19 middle-aged offspring of long-living families from the Leiden Longevity Study together with 18 of their partners as controls. Circulating GH concentrations were measured every 10 min and insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP3) every 4 h. Using deconvolution analysis, we found that 24-h total GH secretion was 28% lower (P = 0.04) in offspring [172 (128-216) mU L(-1) ] compared with controls [238 (193-284) mU L(-1) ]. We used approximate entropy (ApEn) to quantify the strength of feedback/feedforward control of GH secretion. ApEn was lower (P = 0.001) in offspring [0.45 (0.39-0.53)] compared with controls [0.66 (0.56-0.77)], indicating tighter control of GH secretion. No significant differences were observed in circulating levels of IGF-1 and IGFBP3 between offspring and controls. In conclusion, GH secretion in human familial longevity is characterized by diminished secretion rate and more tight control. These data imply that the highly conserved GH signaling pathway, which has been linked to longevity in animal models, is also associated with human longevity.

AB - Reduced growth hormone (GH) signaling has been consistently associated with increased health and lifespan in various mouse models. Here, we assessed GH secretion and its control in relation with human familial longevity. We frequently sampled blood over 24 h in 19 middle-aged offspring of long-living families from the Leiden Longevity Study together with 18 of their partners as controls. Circulating GH concentrations were measured every 10 min and insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP3) every 4 h. Using deconvolution analysis, we found that 24-h total GH secretion was 28% lower (P = 0.04) in offspring [172 (128-216) mU L(-1) ] compared with controls [238 (193-284) mU L(-1) ]. We used approximate entropy (ApEn) to quantify the strength of feedback/feedforward control of GH secretion. ApEn was lower (P = 0.001) in offspring [0.45 (0.39-0.53)] compared with controls [0.66 (0.56-0.77)], indicating tighter control of GH secretion. No significant differences were observed in circulating levels of IGF-1 and IGFBP3 between offspring and controls. In conclusion, GH secretion in human familial longevity is characterized by diminished secretion rate and more tight control. These data imply that the highly conserved GH signaling pathway, which has been linked to longevity in animal models, is also associated with human longevity.

U2 - 10.1111/acel.12519

DO - 10.1111/acel.12519

M3 - Journal article

VL - 15

SP - 1126

EP - 1131

JO - Aging Cell

JF - Aging Cell

SN - 1474-9718

IS - 6

ER -

ID: 166326005