Heavy-Load Lifting: Acute Response in Breast Cancer Survivors at Risk for Lymphedema

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Standard

Heavy-Load Lifting : Acute Response in Breast Cancer Survivors at Risk for Lymphedema. / Bloomquist, Kira; Oturai, Peter; Steele, Megan L; Adamsen, Lis; Møller, Tom; Christensen, Karl Bang; Ejlertsen, Bent; Hayes, Sandra C.

In: Medicine and Science in Sports and Exercise, Vol. 50, No. 2, 02.2018, p. 187-195.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bloomquist, K, Oturai, P, Steele, ML, Adamsen, L, Møller, T, Christensen, KB, Ejlertsen, B & Hayes, SC 2018, 'Heavy-Load Lifting: Acute Response in Breast Cancer Survivors at Risk for Lymphedema', Medicine and Science in Sports and Exercise, vol. 50, no. 2, pp. 187-195. https://doi.org/10.1249/MSS.0000000000001443

APA

Bloomquist, K., Oturai, P., Steele, M. L., Adamsen, L., Møller, T., Christensen, K. B., ... Hayes, S. C. (2018). Heavy-Load Lifting: Acute Response in Breast Cancer Survivors at Risk for Lymphedema. Medicine and Science in Sports and Exercise, 50(2), 187-195. https://doi.org/10.1249/MSS.0000000000001443

Vancouver

Bloomquist K, Oturai P, Steele ML, Adamsen L, Møller T, Christensen KB et al. Heavy-Load Lifting: Acute Response in Breast Cancer Survivors at Risk for Lymphedema. Medicine and Science in Sports and Exercise. 2018 Feb;50(2):187-195. https://doi.org/10.1249/MSS.0000000000001443

Author

Bloomquist, Kira ; Oturai, Peter ; Steele, Megan L ; Adamsen, Lis ; Møller, Tom ; Christensen, Karl Bang ; Ejlertsen, Bent ; Hayes, Sandra C. / Heavy-Load Lifting : Acute Response in Breast Cancer Survivors at Risk for Lymphedema. In: Medicine and Science in Sports and Exercise. 2018 ; Vol. 50, No. 2. pp. 187-195.

Bibtex

@article{82141fc2aa6a414abcfac83fca74271d,
title = "Heavy-Load Lifting: Acute Response in Breast Cancer Survivors at Risk for Lymphedema",
abstract = "PURPOSE: Despite a paucity of evidence, prevention guidelines typically advise avoidance of heavy lifting in an effort to protect against breast cancer-related lymphedema. This study compared acute responses in arm swelling and related symptoms after low- and heavy-load resistance exercise among women at risk for lymphedema while receiving adjuvant taxane-based chemotherapy.METHODS: This is a randomized, crossover equivalence trial. Women receiving adjuvant taxane-based chemotherapy for breast cancer who had undergone axillary lymph node dissection (n = 21) participated in low-load (60{\%}-65{\%} 1-repetition maximum, two sets of 15-20 repetitions) and heavy-load (85{\%}-90{\%} 1-repetition maximum, three sets of 5-8 repetitions) upper-extremity resistance exercise separated by a 1-wk wash-out period. Swelling was determined by bioimpedance spectroscopy and dual-energy x-ray absorptiometry, with breast cancer-related lymphedema symptoms (heaviness, swelling, pain, tightness) reported using a numeric rating scale (0-10). Order of low- versus heavy-load was randomized. All outcomes were assessed before, immediately after, and 24 and 72 h after exercise. Generalized estimating equations were used to evaluate changes over time between groups, with equivalence between resistance exercise loads determined using the principle of confidence interval inclusion.RESULTS: The acute response to resistance exercise was equivalent for all outcomes at all time points irrespective of loads lifted, with the exception of extracellular fluid at 72 h after exercise with less swelling after heavy loads (estimated mean difference, -1.00; 95{\%} confidence interval, -3.17 to 1.17).CONCLUSIONS: Low- and heavy-load resistance exercise elicited similar acute responses in arm swelling and breast cancer-related lymphedema symptoms in women at risk for lymphedema receiving adjuvant taxane-based chemotherapy. These represent important preliminary findings, which can be used to inform future prospective evaluation of the long-term effects of repeated exposure to heavy-load resistance exercise.",
author = "Kira Bloomquist and Peter Oturai and Steele, {Megan L} and Lis Adamsen and Tom M{\o}ller and Christensen, {Karl Bang} and Bent Ejlertsen and Hayes, {Sandra C}",
year = "2018",
month = "2",
doi = "10.1249/MSS.0000000000001443",
language = "English",
volume = "50",
pages = "187--195",
journal = "Medicine and Science in Sports and Exercise",
issn = "0195-9131",
publisher = "Lippincott Williams & Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - Heavy-Load Lifting

T2 - Acute Response in Breast Cancer Survivors at Risk for Lymphedema

AU - Bloomquist, Kira

AU - Oturai, Peter

AU - Steele, Megan L

AU - Adamsen, Lis

AU - Møller, Tom

AU - Christensen, Karl Bang

AU - Ejlertsen, Bent

AU - Hayes, Sandra C

PY - 2018/2

Y1 - 2018/2

N2 - PURPOSE: Despite a paucity of evidence, prevention guidelines typically advise avoidance of heavy lifting in an effort to protect against breast cancer-related lymphedema. This study compared acute responses in arm swelling and related symptoms after low- and heavy-load resistance exercise among women at risk for lymphedema while receiving adjuvant taxane-based chemotherapy.METHODS: This is a randomized, crossover equivalence trial. Women receiving adjuvant taxane-based chemotherapy for breast cancer who had undergone axillary lymph node dissection (n = 21) participated in low-load (60%-65% 1-repetition maximum, two sets of 15-20 repetitions) and heavy-load (85%-90% 1-repetition maximum, three sets of 5-8 repetitions) upper-extremity resistance exercise separated by a 1-wk wash-out period. Swelling was determined by bioimpedance spectroscopy and dual-energy x-ray absorptiometry, with breast cancer-related lymphedema symptoms (heaviness, swelling, pain, tightness) reported using a numeric rating scale (0-10). Order of low- versus heavy-load was randomized. All outcomes were assessed before, immediately after, and 24 and 72 h after exercise. Generalized estimating equations were used to evaluate changes over time between groups, with equivalence between resistance exercise loads determined using the principle of confidence interval inclusion.RESULTS: The acute response to resistance exercise was equivalent for all outcomes at all time points irrespective of loads lifted, with the exception of extracellular fluid at 72 h after exercise with less swelling after heavy loads (estimated mean difference, -1.00; 95% confidence interval, -3.17 to 1.17).CONCLUSIONS: Low- and heavy-load resistance exercise elicited similar acute responses in arm swelling and breast cancer-related lymphedema symptoms in women at risk for lymphedema receiving adjuvant taxane-based chemotherapy. These represent important preliminary findings, which can be used to inform future prospective evaluation of the long-term effects of repeated exposure to heavy-load resistance exercise.

AB - PURPOSE: Despite a paucity of evidence, prevention guidelines typically advise avoidance of heavy lifting in an effort to protect against breast cancer-related lymphedema. This study compared acute responses in arm swelling and related symptoms after low- and heavy-load resistance exercise among women at risk for lymphedema while receiving adjuvant taxane-based chemotherapy.METHODS: This is a randomized, crossover equivalence trial. Women receiving adjuvant taxane-based chemotherapy for breast cancer who had undergone axillary lymph node dissection (n = 21) participated in low-load (60%-65% 1-repetition maximum, two sets of 15-20 repetitions) and heavy-load (85%-90% 1-repetition maximum, three sets of 5-8 repetitions) upper-extremity resistance exercise separated by a 1-wk wash-out period. Swelling was determined by bioimpedance spectroscopy and dual-energy x-ray absorptiometry, with breast cancer-related lymphedema symptoms (heaviness, swelling, pain, tightness) reported using a numeric rating scale (0-10). Order of low- versus heavy-load was randomized. All outcomes were assessed before, immediately after, and 24 and 72 h after exercise. Generalized estimating equations were used to evaluate changes over time between groups, with equivalence between resistance exercise loads determined using the principle of confidence interval inclusion.RESULTS: The acute response to resistance exercise was equivalent for all outcomes at all time points irrespective of loads lifted, with the exception of extracellular fluid at 72 h after exercise with less swelling after heavy loads (estimated mean difference, -1.00; 95% confidence interval, -3.17 to 1.17).CONCLUSIONS: Low- and heavy-load resistance exercise elicited similar acute responses in arm swelling and breast cancer-related lymphedema symptoms in women at risk for lymphedema receiving adjuvant taxane-based chemotherapy. These represent important preliminary findings, which can be used to inform future prospective evaluation of the long-term effects of repeated exposure to heavy-load resistance exercise.

U2 - 10.1249/MSS.0000000000001443

DO - 10.1249/MSS.0000000000001443

M3 - Journal article

VL - 50

SP - 187

EP - 195

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 2

ER -

ID: 199063288