TY - JOUR

T1 - Impact of dietary exposure to food contaminants on the risk of Parkinson's disease

AU - Petersen, Maria Skaalum

AU - Halling, Jónrit

AU - Bech, Sára

AU - Wermuth, Lene

AU - Weihe, Pál

AU - Nielsen, Flemming

AU - Jørgensen, Poul J

AU - Budtz-Jørgensen, Esben

AU - Grandjean, Philippe

N1 - Keywords: Aged; Aged, 80 and over; Case-Control Studies; Confidence Intervals; Diet; Environmental Exposure; Female; Food Contamination; Humans; Male; Neurologic Examination; Occupational Diseases; Odds Ratio; Parkinson Disease; Risk; Sex Factors

PY - 2008

Y1 - 2008

N2 - This study aimed to investigate the association of Parkinson's disease (PD) with dietary exposure to polychlorinated biphenyls (PCBs) and methylmercury (MeHg) in a community with increased exposure levels. A total of 79 clinically verified idiopathic PD cases and 154 controls matched by sex and age were examined in this case-control study in the Faroe Islands. Blood and hair samples were collected and a questionnaire recorded lifetime information on residence, dietary habits, smoking history, and occupational exposure to solvents, pesticides, and metals. Both unconditional and conditional logistic regression analyses were used to estimate the odds ratio (OR) and 95% confidence interval (CI) in regard to relevant exposure variables. Increased ORs for dietary intakes of whale meat and blubber during adult life were statistically significant. The ORs for occupational exposure to solvents, pesticides and metals also suggested an increased risk for PD. Current serum concentrations of summation operator PCB and related contaminants suggested slightly increased ORs, although only beta-hexachlorocyclohexane (beta-HCH) was statistically significant. Increased intake of whale meat and blubber in adult life was significantly associated with PD, thus suggesting a positive association between previous exposure to marine food contaminants and development of PD.

AB - This study aimed to investigate the association of Parkinson's disease (PD) with dietary exposure to polychlorinated biphenyls (PCBs) and methylmercury (MeHg) in a community with increased exposure levels. A total of 79 clinically verified idiopathic PD cases and 154 controls matched by sex and age were examined in this case-control study in the Faroe Islands. Blood and hair samples were collected and a questionnaire recorded lifetime information on residence, dietary habits, smoking history, and occupational exposure to solvents, pesticides, and metals. Both unconditional and conditional logistic regression analyses were used to estimate the odds ratio (OR) and 95% confidence interval (CI) in regard to relevant exposure variables. Increased ORs for dietary intakes of whale meat and blubber during adult life were statistically significant. The ORs for occupational exposure to solvents, pesticides and metals also suggested an increased risk for PD. Current serum concentrations of summation operator PCB and related contaminants suggested slightly increased ORs, although only beta-hexachlorocyclohexane (beta-HCH) was statistically significant. Increased intake of whale meat and blubber in adult life was significantly associated with PD, thus suggesting a positive association between previous exposure to marine food contaminants and development of PD.

U2 - 10.1016/j.neuro.2008.03.001

DO - 10.1016/j.neuro.2008.03.001

M3 - Journal article

C2 - 18455239

VL - 29

SP - 584

EP - 590

JO - NeuroToxicology

JF - NeuroToxicology

SN - 0161-813X

IS - 4

ER -