TY - JOUR

T1 - Impact of persistence and non-persistence in leisure time physical activity on coronary heart disease and all-cause mortality

T2 - The Copenhagen City Heart Study

AU - Schnohr, Peter

AU - O'Keefe, James H.

AU - Lange, Peter

AU - Jensen, Gorm Boje

AU - Marott, Jacob Louis

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Aims: The aim of this study was to investigate the impact of persistence and non-persistence in leisure time physical activity on coronary heart disease and all-cause mortality.Methods and results: In the Copenhagen City Heart Study, we prospectively followed 12,314 healthy subjects for 33 years of maximum follow-up with at least two repeated measures of physical activity. The association between persistence and non-persistence in leisure time physical activity, coronary heart disease and all-cause mortality were assessed by multivariable Cox regression analyses. Coronary heart disease mortality for persistent physical activity in leisure compared to persistent sedentary activity were: light hazard ratio (HR) 0.76; 95% confidence interval (CI) 0.63–0.92, moderate HR 0.52; 95% CI 0.41–0.67, and high physical activity HR 0.51; 95% CI, 0.30–0.88. The differences in longevity were 2.8 years for light, 4.5 years for moderate and 5.5 years for high physical activity. A substantial increase in physical activity was associated with lower coronary heart disease mortality (HR 0.75; 95% CI 0.52–1.08) corresponding to 2.4 years longer life, whereas a substantial decrease in physical activity was associated with higher coronary heart disease mortality (HR 1.61; 95% CI 1.11–2.33) corresponding to 4.2 years shorter life than the unchanged group. A similar pattern was observed for all-cause mortality.Conclusion: We found inverse dose–response relationships between persistent leisure time physical activity and both coronary heart disease and all-cause mortality. A substantial increase in physical activity was associated with a significant gain in longevity, whereas a decrease in physical activity was associated with even greater loss of longevity.

AB - Aims: The aim of this study was to investigate the impact of persistence and non-persistence in leisure time physical activity on coronary heart disease and all-cause mortality.Methods and results: In the Copenhagen City Heart Study, we prospectively followed 12,314 healthy subjects for 33 years of maximum follow-up with at least two repeated measures of physical activity. The association between persistence and non-persistence in leisure time physical activity, coronary heart disease and all-cause mortality were assessed by multivariable Cox regression analyses. Coronary heart disease mortality for persistent physical activity in leisure compared to persistent sedentary activity were: light hazard ratio (HR) 0.76; 95% confidence interval (CI) 0.63–0.92, moderate HR 0.52; 95% CI 0.41–0.67, and high physical activity HR 0.51; 95% CI, 0.30–0.88. The differences in longevity were 2.8 years for light, 4.5 years for moderate and 5.5 years for high physical activity. A substantial increase in physical activity was associated with lower coronary heart disease mortality (HR 0.75; 95% CI 0.52–1.08) corresponding to 2.4 years longer life, whereas a substantial decrease in physical activity was associated with higher coronary heart disease mortality (HR 1.61; 95% CI 1.11–2.33) corresponding to 4.2 years shorter life than the unchanged group. A similar pattern was observed for all-cause mortality.Conclusion: We found inverse dose–response relationships between persistent leisure time physical activity and both coronary heart disease and all-cause mortality. A substantial increase in physical activity was associated with a significant gain in longevity, whereas a decrease in physical activity was associated with even greater loss of longevity.

KW - Physical activity in leisure time

KW - persistence

KW - non-persistence

KW - coronary heart disease

KW - all-cause mortality

U2 - 10.1177/2047487317721021

DO - 10.1177/2047487317721021

M3 - Journal article

C2 - 28728482

VL - 24

SP - 1615

EP - 1623

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

SN - 2047-4873

IS - 15

ER -