Incidence of HPV-related Anogenital Intraepithelial Neoplasia and Cancer in Men with Diabetes Compared with the General Population
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Incidence of HPV-related Anogenital Intraepithelial Neoplasia and Cancer in Men with Diabetes Compared with the General Population. / Reinholdt, Kristian; Thomsen, Louise Thirstrup; Munk, Christian; Dehlendorff, Christian; Carstensen, Bendix; Jørgensen, Marit Eika; Kjaer, Susanne Krüger.
In: Epidemiology, Vol. 32, No. 5, 2021, p. 705-711.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Incidence of HPV-related Anogenital Intraepithelial Neoplasia and Cancer in Men with Diabetes Compared with the General Population
AU - Reinholdt, Kristian
AU - Thomsen, Louise Thirstrup
AU - Munk, Christian
AU - Dehlendorff, Christian
AU - Carstensen, Bendix
AU - Jørgensen, Marit Eika
AU - Kjaer, Susanne Krüger
N1 - Publisher Copyright: © 2021 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Background: Diabetes may increase risk of human papillomavirus (HPV)-related precancer and cancer. We estimated incidence of penile and anal high-grade intraepithelial neoplasia (hgPeIN, hgAIN) and squamous cell carcinoma (SCC) in men with diabetes compared with the entire Danish male population without diabetes. Methods: In this registry-based cohort study, we included all men born 1916-2001 and residing in Denmark (n = 2,528,756). From nationwide registries, we retrieved individual-level information on diabetes, educational level, and diagnoses of hgPeIN, hgAIN, penile SCC, and anal SCC. We used Poisson regression models to estimate incidence of hgPeIN, hgAIN, penile SCC, and anal SCC as a function of diabetes status, attained age, calendar period, and education. We estimated incidence rate ratios (IRRs) of each outcome in men with diabetes compared with nondiabetic men, both for diabetes overall and separately for type 1 (T1D) and type 2 diabetes (T2D). Results: Men with diabetes had increased incidence rate of penile SCC compared with nondiabetic men (IRR = 1.5, 95% CI = 1.2, 1.9). We saw similar trends for anal SCC, hgPeIN, and hgAIN. The combined incidence rate of penile and anal SCC was increased in men with T2D (IRR = 1.5, 95% CI = 1.3, 1.8), but not with T1D (IRR = 0.53, 95% CI = 0.20, 1.4) compared with men without diabetes. Conclusion: The incidence of penile and anal high-grade intraepithelial neoplasia and SCC in men with diabetes was increased compared with men without diabetes. For penile and anal SCCs, this was primarily due to an increased risk in men with T2D.
AB - Background: Diabetes may increase risk of human papillomavirus (HPV)-related precancer and cancer. We estimated incidence of penile and anal high-grade intraepithelial neoplasia (hgPeIN, hgAIN) and squamous cell carcinoma (SCC) in men with diabetes compared with the entire Danish male population without diabetes. Methods: In this registry-based cohort study, we included all men born 1916-2001 and residing in Denmark (n = 2,528,756). From nationwide registries, we retrieved individual-level information on diabetes, educational level, and diagnoses of hgPeIN, hgAIN, penile SCC, and anal SCC. We used Poisson regression models to estimate incidence of hgPeIN, hgAIN, penile SCC, and anal SCC as a function of diabetes status, attained age, calendar period, and education. We estimated incidence rate ratios (IRRs) of each outcome in men with diabetes compared with nondiabetic men, both for diabetes overall and separately for type 1 (T1D) and type 2 diabetes (T2D). Results: Men with diabetes had increased incidence rate of penile SCC compared with nondiabetic men (IRR = 1.5, 95% CI = 1.2, 1.9). We saw similar trends for anal SCC, hgPeIN, and hgAIN. The combined incidence rate of penile and anal SCC was increased in men with T2D (IRR = 1.5, 95% CI = 1.3, 1.8), but not with T1D (IRR = 0.53, 95% CI = 0.20, 1.4) compared with men without diabetes. Conclusion: The incidence of penile and anal high-grade intraepithelial neoplasia and SCC in men with diabetes was increased compared with men without diabetes. For penile and anal SCCs, this was primarily due to an increased risk in men with T2D.
KW - Anal
KW - Cancer
KW - Diabetes
KW - High-grade intraepithelial neoplasia
KW - Nationwide cohort
KW - Penile
U2 - 10.1097/EDE.0000000000001375
DO - 10.1097/EDE.0000000000001375
M3 - Journal article
C2 - 34039899
AN - SCOPUS:85112607132
VL - 32
SP - 705
EP - 711
JO - Epidemiology
JF - Epidemiology
SN - 1044-3983
IS - 5
ER -
ID: 301459543