Increased Contractile Response to Noradrenaline Induced By Factors Associated with the Metabolic Syndrome in Cultured Small Mesenteric Arteries

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Increased Contractile Response to Noradrenaline Induced By Factors Associated with the Metabolic Syndrome in Cultured Small Mesenteric Arteries. / Blædel, Martin; Sams, Anette; Boonen, Harrie C M; Sheykhzade, Majid.

In: Pharmacology, Vol. 97, No. 1-2, 2016, p. 48-56.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Blædel, M, Sams, A, Boonen, HCM & Sheykhzade, M 2016, 'Increased Contractile Response to Noradrenaline Induced By Factors Associated with the Metabolic Syndrome in Cultured Small Mesenteric Arteries', Pharmacology, vol. 97, no. 1-2, pp. 48-56. https://doi.org/10.1159/000442259

APA

Blædel, M., Sams, A., Boonen, H. C. M., & Sheykhzade, M. (2016). Increased Contractile Response to Noradrenaline Induced By Factors Associated with the Metabolic Syndrome in Cultured Small Mesenteric Arteries. Pharmacology, 97(1-2), 48-56. https://doi.org/10.1159/000442259

Vancouver

Blædel M, Sams A, Boonen HCM, Sheykhzade M. Increased Contractile Response to Noradrenaline Induced By Factors Associated with the Metabolic Syndrome in Cultured Small Mesenteric Arteries. Pharmacology. 2016;97(1-2):48-56. https://doi.org/10.1159/000442259

Author

Blædel, Martin ; Sams, Anette ; Boonen, Harrie C M ; Sheykhzade, Majid. / Increased Contractile Response to Noradrenaline Induced By Factors Associated with the Metabolic Syndrome in Cultured Small Mesenteric Arteries. In: Pharmacology. 2016 ; Vol. 97, No. 1-2. pp. 48-56.

Bibtex

@article{2eefca02cd744a0db19369083932c47a,

title = "Increased Contractile Response to Noradrenaline Induced By Factors Associated with the Metabolic Syndrome in Cultured Small Mesenteric Arteries",

abstract = "UNLABELLED: This study investigated the effect of the metabolic syndrome associated risk factors hyperglycemia (glucose [Glc]), hyperinsulinemia (insulin [Ins]) and low-grade inflammation (tumor necrosis factor α [TNFα]) on the vasomotor responses of resistance arteries. Isolated small mesenteric arteries from 3-month-old Sprague-Dawley rats, were suspended for 21-23 h in tissue cultures containing either elevated Glc (30 mmol/l), Ins (100 nmol/l), TNFα (100 ng/ml) or combinations thereof. After incubation, the vascular response to noradrenaline (NA), phenylephrine, isoprenaline and NA in the presence of propranolol (10 µmol/l) was measured by wire myography.RESULTS: Arteries exposed only to combinations of the risk factors showed a significant 1.6-fold increase in the contractile NA sensitivity, which suggests that complex combinations of metabolic risk factors might lead to changes in vascular tone.",

author = "Martin Bl{\ae}del and Anette Sams and Boonen, {Harrie C M} and Majid Sheykhzade",

note = "{\textcopyright} 2015 S. Karger AG, Basel.",

year = "2016",

doi = "10.1159/000442259",

language = "English",

volume = "97",

pages = "48--56",

journal = "Pharmacology",

issn = "0031-7012",

publisher = "S Karger AG",

number = "1-2",

}

RIS

TY - JOUR

T1 - Increased Contractile Response to Noradrenaline Induced By Factors Associated with the Metabolic Syndrome in Cultured Small Mesenteric Arteries

AU - Blædel, Martin

AU - Sams, Anette

AU - Boonen, Harrie C M

AU - Sheykhzade, Majid

PY - 2016

Y1 - 2016

N2 - UNLABELLED: This study investigated the effect of the metabolic syndrome associated risk factors hyperglycemia (glucose [Glc]), hyperinsulinemia (insulin [Ins]) and low-grade inflammation (tumor necrosis factor α [TNFα]) on the vasomotor responses of resistance arteries. Isolated small mesenteric arteries from 3-month-old Sprague-Dawley rats, were suspended for 21-23 h in tissue cultures containing either elevated Glc (30 mmol/l), Ins (100 nmol/l), TNFα (100 ng/ml) or combinations thereof. After incubation, the vascular response to noradrenaline (NA), phenylephrine, isoprenaline and NA in the presence of propranolol (10 µmol/l) was measured by wire myography.RESULTS: Arteries exposed only to combinations of the risk factors showed a significant 1.6-fold increase in the contractile NA sensitivity, which suggests that complex combinations of metabolic risk factors might lead to changes in vascular tone.

AB - UNLABELLED: This study investigated the effect of the metabolic syndrome associated risk factors hyperglycemia (glucose [Glc]), hyperinsulinemia (insulin [Ins]) and low-grade inflammation (tumor necrosis factor α [TNFα]) on the vasomotor responses of resistance arteries. Isolated small mesenteric arteries from 3-month-old Sprague-Dawley rats, were suspended for 21-23 h in tissue cultures containing either elevated Glc (30 mmol/l), Ins (100 nmol/l), TNFα (100 ng/ml) or combinations thereof. After incubation, the vascular response to noradrenaline (NA), phenylephrine, isoprenaline and NA in the presence of propranolol (10 µmol/l) was measured by wire myography.RESULTS: Arteries exposed only to combinations of the risk factors showed a significant 1.6-fold increase in the contractile NA sensitivity, which suggests that complex combinations of metabolic risk factors might lead to changes in vascular tone.

U2 - 10.1159/000442259

DO - 10.1159/000442259

M3 - Journal article

C2 - 26587661

VL - 97

SP - 48

EP - 56

JO - Pharmacology

JF - Pharmacology

SN - 0031-7012

IS - 1-2

ER -

ID: 154041831

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