Increased risk of type 2 diabetes in elderly twins

Research output: Contribution to journalJournal articleResearchpeer-review

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Increased risk of type 2 diabetes in elderly twins. / Poulsen, Pernille; Grunnet, Louise G; Pilgaard, Kasper; Storgaard, Heidi; Alibegovic, Amra; Sonne, Mette P; Carstensen, Bendix; Beck-Nielsen, Henning; Vaag, Allan.

In: Diabetes, Vol. 58, No. 6, 2009, p. 1350-5.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Poulsen, P, Grunnet, LG, Pilgaard, K, Storgaard, H, Alibegovic, A, Sonne, MP, Carstensen, B, Beck-Nielsen, H & Vaag, A 2009, 'Increased risk of type 2 diabetes in elderly twins', Diabetes, vol. 58, no. 6, pp. 1350-5. https://doi.org/10.2337/db08-1714

APA

Poulsen, P., Grunnet, L. G., Pilgaard, K., Storgaard, H., Alibegovic, A., Sonne, M. P., ... Vaag, A. (2009). Increased risk of type 2 diabetes in elderly twins. Diabetes, 58(6), 1350-5. https://doi.org/10.2337/db08-1714

Vancouver

Poulsen P, Grunnet LG, Pilgaard K, Storgaard H, Alibegovic A, Sonne MP et al. Increased risk of type 2 diabetes in elderly twins. Diabetes. 2009;58(6):1350-5. https://doi.org/10.2337/db08-1714

Author

Poulsen, Pernille ; Grunnet, Louise G ; Pilgaard, Kasper ; Storgaard, Heidi ; Alibegovic, Amra ; Sonne, Mette P ; Carstensen, Bendix ; Beck-Nielsen, Henning ; Vaag, Allan. / Increased risk of type 2 diabetes in elderly twins. In: Diabetes. 2009 ; Vol. 58, No. 6. pp. 1350-5.

Bibtex

@article{59544720366011df8ed1000ea68e967b,
title = "Increased risk of type 2 diabetes in elderly twins",
abstract = "OBJECTIVE: Genetic susceptibility, low birth weight (LBW), and aging are key etiological factors in the development of type 2 diabetes. LBW is common among twins. It is unknown whether twin status per se is associated with risk of type 2 diabetes, and valid concordance rates of type 2 diabetes in twins on a lifetime perspective are lacking. RESEARCH DESIGN AND METHODS: A clinical study was done on a population-based cohort of same-sex elderly monozygotic (MZ) and dizygotic (DZ) twins (n = 297) and singleton control subjects (C) (n = 71) including measures of anthropometry and glucose tolerance. In addition, type 2 diabetes incidence cases in twins (n = 626) and singletons (n = 553) were identified through the National Diabetes Register. RESULTS: Twins were more abdominally obese, insulin resistant, and glucose intolerant, as evidenced by a higher A1C ({\%}) (means +/- SD) (MZ: 6.0 +/- 1.0, DZ: 5.8 +/- 0.7, C: 5.6 +/- 0.3, P = 0.004) and 120-min post-oral glucose tolerance test plasma glucose levels (in mmol/l) (MZ: 8.6 +/- 4.6, DZ: 8.4 +/- 3.9, C: 6.8 +/- 2.4, P = 0.003) compared with singletons. Importantly, twins had a higher prevalence of type 2 diabetes (MZ: 17.5{\%} [95{\%} CI 14.4-20.6], DZ: 15.7{\%} [13.1-18.3], C: 5.6{\%} [3.0-8.2], P = 0.03) together with a 60{\%} higher incidence rate of type 2 diabetes compared with singletons. Cumulative concordance rates of type 2 diabetes to the age of 84 years were similar among elderly MZ (0.76 [0.68-0.84]) and DZ (0.71 [0.63-0.78]) twins. CONCLUSIONS: Twin status per se is associated with abdominal obesity, insulin resistance, and increased prevalence of type 2 diabetes in elderly twins. The data support a quantitatively significant impact of the fetal environment as opposed to genetics on risk of type 2 diabetes.",
author = "Pernille Poulsen and Grunnet, {Louise G} and Kasper Pilgaard and Heidi Storgaard and Amra Alibegovic and Sonne, {Mette P} and Bendix Carstensen and Henning Beck-Nielsen and Allan Vaag",
note = "Keywords: Aged; Birth Weight; Diabetes Mellitus, Type 2; Diseases in Twins; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Infant, Low Birth Weight; Infant, Newborn; Male; Registries; Risk Factors; Spouses; Time Factors; Twins, Dizygotic; Twins, Monozygotic",
year = "2009",
doi = "10.2337/db08-1714",
language = "English",
volume = "58",
pages = "1350--5",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "6",

}

RIS

TY - JOUR

T1 - Increased risk of type 2 diabetes in elderly twins

AU - Poulsen, Pernille

AU - Grunnet, Louise G

AU - Pilgaard, Kasper

AU - Storgaard, Heidi

AU - Alibegovic, Amra

AU - Sonne, Mette P

AU - Carstensen, Bendix

AU - Beck-Nielsen, Henning

AU - Vaag, Allan

N1 - Keywords: Aged; Birth Weight; Diabetes Mellitus, Type 2; Diseases in Twins; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Infant, Low Birth Weight; Infant, Newborn; Male; Registries; Risk Factors; Spouses; Time Factors; Twins, Dizygotic; Twins, Monozygotic

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: Genetic susceptibility, low birth weight (LBW), and aging are key etiological factors in the development of type 2 diabetes. LBW is common among twins. It is unknown whether twin status per se is associated with risk of type 2 diabetes, and valid concordance rates of type 2 diabetes in twins on a lifetime perspective are lacking. RESEARCH DESIGN AND METHODS: A clinical study was done on a population-based cohort of same-sex elderly monozygotic (MZ) and dizygotic (DZ) twins (n = 297) and singleton control subjects (C) (n = 71) including measures of anthropometry and glucose tolerance. In addition, type 2 diabetes incidence cases in twins (n = 626) and singletons (n = 553) were identified through the National Diabetes Register. RESULTS: Twins were more abdominally obese, insulin resistant, and glucose intolerant, as evidenced by a higher A1C (%) (means +/- SD) (MZ: 6.0 +/- 1.0, DZ: 5.8 +/- 0.7, C: 5.6 +/- 0.3, P = 0.004) and 120-min post-oral glucose tolerance test plasma glucose levels (in mmol/l) (MZ: 8.6 +/- 4.6, DZ: 8.4 +/- 3.9, C: 6.8 +/- 2.4, P = 0.003) compared with singletons. Importantly, twins had a higher prevalence of type 2 diabetes (MZ: 17.5% [95% CI 14.4-20.6], DZ: 15.7% [13.1-18.3], C: 5.6% [3.0-8.2], P = 0.03) together with a 60% higher incidence rate of type 2 diabetes compared with singletons. Cumulative concordance rates of type 2 diabetes to the age of 84 years were similar among elderly MZ (0.76 [0.68-0.84]) and DZ (0.71 [0.63-0.78]) twins. CONCLUSIONS: Twin status per se is associated with abdominal obesity, insulin resistance, and increased prevalence of type 2 diabetes in elderly twins. The data support a quantitatively significant impact of the fetal environment as opposed to genetics on risk of type 2 diabetes.

AB - OBJECTIVE: Genetic susceptibility, low birth weight (LBW), and aging are key etiological factors in the development of type 2 diabetes. LBW is common among twins. It is unknown whether twin status per se is associated with risk of type 2 diabetes, and valid concordance rates of type 2 diabetes in twins on a lifetime perspective are lacking. RESEARCH DESIGN AND METHODS: A clinical study was done on a population-based cohort of same-sex elderly monozygotic (MZ) and dizygotic (DZ) twins (n = 297) and singleton control subjects (C) (n = 71) including measures of anthropometry and glucose tolerance. In addition, type 2 diabetes incidence cases in twins (n = 626) and singletons (n = 553) were identified through the National Diabetes Register. RESULTS: Twins were more abdominally obese, insulin resistant, and glucose intolerant, as evidenced by a higher A1C (%) (means +/- SD) (MZ: 6.0 +/- 1.0, DZ: 5.8 +/- 0.7, C: 5.6 +/- 0.3, P = 0.004) and 120-min post-oral glucose tolerance test plasma glucose levels (in mmol/l) (MZ: 8.6 +/- 4.6, DZ: 8.4 +/- 3.9, C: 6.8 +/- 2.4, P = 0.003) compared with singletons. Importantly, twins had a higher prevalence of type 2 diabetes (MZ: 17.5% [95% CI 14.4-20.6], DZ: 15.7% [13.1-18.3], C: 5.6% [3.0-8.2], P = 0.03) together with a 60% higher incidence rate of type 2 diabetes compared with singletons. Cumulative concordance rates of type 2 diabetes to the age of 84 years were similar among elderly MZ (0.76 [0.68-0.84]) and DZ (0.71 [0.63-0.78]) twins. CONCLUSIONS: Twin status per se is associated with abdominal obesity, insulin resistance, and increased prevalence of type 2 diabetes in elderly twins. The data support a quantitatively significant impact of the fetal environment as opposed to genetics on risk of type 2 diabetes.

U2 - 10.2337/db08-1714

DO - 10.2337/db08-1714

M3 - Journal article

C2 - 19336677

VL - 58

SP - 1350

EP - 1355

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 6

ER -

ID: 18787733