TY - JOUR

T1 - Índice de masa corporal y ganancia de peso durante el embarazo como predictores de niveles de hemoglobina materna y su asociación con desenlaces neonatales en una cohorte mexicana

AU - Cantoral, Alejandra

AU - Ramírez-Silva, Ivonne

AU - Lamadrid-Figueroa, Héctor

AU - Christensen, Dirk L.

AU - Bygbjerg, Ib C.

AU - Groth-Grunnet, Louise

AU - Nielsen, Karoline K.

AU - Granich-Armenta, Adriana

AU - Ávila-Jiménez, Laura

AU - Dommarco, Juan Ángel Rivera

N1 - Funding Information: Funding: this work was supported by CONACYT under Grant number 233439, and Danish International Development Agency under Grant number 19-M06-KU. Funding Information: The authors declare that they have no competing interests. DLC has participated in consultancy meetings in Mexico paid by Novo Nordisk Mexico. LGG and kkN are both employed at Steno Diabetes Center Copenhagen, a public hospital and research institution under the Capital Region of Denmark, which is partly funded by a grant from Novo Nordisk Foundation. ICB is a consultant and former board member at World Diabetes Foundation, which is supported financially by the Novo Nordisk Foundation. Publisher Copyright: © 2022, Nutricion Hospitalaria.

PY - 2022

Y1 - 2022

N2 - Introduction: there is scarce evidence of the effects of obesity and gestational weight-gain (GWG) on hemoglobin (Hb) levels in pregnancy. Little is known about the implications in offspring when pregnant mothers present with both at delivery. Aim: to identify if pre-pregnancy body mass index (BMI) and GWG are associated with Hb levels at pregnancy third trimester; and identify if the BMI status plus anemia at delivery could influence offspring anthropometry. Methods: in a sub-sample of pregnant women (n = 108) and their offspring (n = 63) from a Mexican birth cohort, information from medical files and questionnaires were used to obtain pre-pregnancy BMI (categorized as normal, overweight, and obese), GWG, and Hb during pregnancy; at delivery and postpartum anthropometric measures were obtained for offspring. Adjusted regression models predicted Hb levels according to pre-pregnancy BMI and GWG; offspring growth trajectories from birth to 3 months old were compared according to mother´s BMI status and anemia combinations at delivery. Results: pre-pregnancy normal (N), overweight (OV), and obesity (OB) were present in 48 %, 40 %, and 12 % of the participants, respectively. Anemia was detected in 22.8 % of the participants at third trimester. Hb levels in the third trimester were significantly lower in those with pre-pregnancy OB-BMI and excessive GWG (12.1 g/dL, 95 % CI: 10.7-13.5) compared to those with pre-pregnancy OB-BMI and insufficient GWG (13.3g/dL, 95 %CI: 11.9-14.8) (p = 0.04). At delivery, 11 % presented with OB-BMI and anemia. Women with OB-BMI and normal Hb levels had children with higher scores in Weight-for-Length-Z score and triceps skinfold. Conclusion: among OB women, excessive GWG was associated with having lower Hb levels in the third trimester. Newborns had higher scores in growth patterns related to adiposity from birth to 3 months old if mothers had normal Hb levels and OB.

AB - Introduction: there is scarce evidence of the effects of obesity and gestational weight-gain (GWG) on hemoglobin (Hb) levels in pregnancy. Little is known about the implications in offspring when pregnant mothers present with both at delivery. Aim: to identify if pre-pregnancy body mass index (BMI) and GWG are associated with Hb levels at pregnancy third trimester; and identify if the BMI status plus anemia at delivery could influence offspring anthropometry. Methods: in a sub-sample of pregnant women (n = 108) and their offspring (n = 63) from a Mexican birth cohort, information from medical files and questionnaires were used to obtain pre-pregnancy BMI (categorized as normal, overweight, and obese), GWG, and Hb during pregnancy; at delivery and postpartum anthropometric measures were obtained for offspring. Adjusted regression models predicted Hb levels according to pre-pregnancy BMI and GWG; offspring growth trajectories from birth to 3 months old were compared according to mother´s BMI status and anemia combinations at delivery. Results: pre-pregnancy normal (N), overweight (OV), and obesity (OB) were present in 48 %, 40 %, and 12 % of the participants, respectively. Anemia was detected in 22.8 % of the participants at third trimester. Hb levels in the third trimester were significantly lower in those with pre-pregnancy OB-BMI and excessive GWG (12.1 g/dL, 95 % CI: 10.7-13.5) compared to those with pre-pregnancy OB-BMI and insufficient GWG (13.3g/dL, 95 %CI: 11.9-14.8) (p = 0.04). At delivery, 11 % presented with OB-BMI and anemia. Women with OB-BMI and normal Hb levels had children with higher scores in Weight-for-Length-Z score and triceps skinfold. Conclusion: among OB women, excessive GWG was associated with having lower Hb levels in the third trimester. Newborns had higher scores in growth patterns related to adiposity from birth to 3 months old if mothers had normal Hb levels and OB.

KW - Anemia

KW - Gestational weight gain

KW - Overweight

KW - Pregnancy

U2 - 10.20960/nh.03999

DO - 10.20960/nh.03999

M3 - Tidsskriftartikel

C2 - 35916135

AN - SCOPUS:85135338683

VL - 39

SP - 852

EP - 862

JO - Nutricion Hospitalaria

JF - Nutricion Hospitalaria

SN - 0212-1611

IS - 4

ER -