TY - JOUR

T1 - Individual testosterone decline and future mortality risk in men

AU - Holmboe, Stine Agergaard

AU - Skakkebaek, Niels E.

AU - Juul, Anders

AU - Scheike, Thomas

AU - Jensen, Tina Kold

AU - Linneberg, Allan

AU - Thuesen, Betina H.

AU - Andersson, Anna-Maria

PY - 2018/1

Y1 - 2018/1

N2 - OBJECTIVE: Male aging is characterized by a decline in testosterone (T) levels with a substantial variability between subjects. However, it is unclear whether differences in age-related changes in T are associated with general health. We investigated associations between mortality and intra-individual changes in serum levels of total T, SHBG, free T, estradiol and LH during a ten year period with up to 18 years of registry follow-up.DESIGN: 1,167 men aged 30 to 60 years participating in the Danish Monitoring Trends and Determinants of Cardiovascular Disease (MONICA1) study and who had a follow-up examination ten years later (MONICA10) were included. From MONICA10 the men were followed up to 18 years (mean: 15.2 years) in national mortality registries via their unique personal ID number.METHODS: Cox proportional hazard models were used to investigate the association between intra-individual hormone changes and all-cause-, CVD-, and cancer mortality.RESULTS: A total of 421 men (36.1%) died during the follow-up period. Men with most pronounced decline in total T (<10th percentile) had a higher all-cause mortality risk compared to men within the 10th to 90th percentile (hazard ratio [HR], 1.60; 95% confidence interval [CI], 1.08-2.36). No consistent associations were seen in cause-specific mortality analyses.CONCLUSION: Our study showed that higher mortality rates were seen among the men who had the most pronounced age-related decline in T, independent of their baseline T levels.

AB - OBJECTIVE: Male aging is characterized by a decline in testosterone (T) levels with a substantial variability between subjects. However, it is unclear whether differences in age-related changes in T are associated with general health. We investigated associations between mortality and intra-individual changes in serum levels of total T, SHBG, free T, estradiol and LH during a ten year period with up to 18 years of registry follow-up.DESIGN: 1,167 men aged 30 to 60 years participating in the Danish Monitoring Trends and Determinants of Cardiovascular Disease (MONICA1) study and who had a follow-up examination ten years later (MONICA10) were included. From MONICA10 the men were followed up to 18 years (mean: 15.2 years) in national mortality registries via their unique personal ID number.METHODS: Cox proportional hazard models were used to investigate the association between intra-individual hormone changes and all-cause-, CVD-, and cancer mortality.RESULTS: A total of 421 men (36.1%) died during the follow-up period. Men with most pronounced decline in total T (<10th percentile) had a higher all-cause mortality risk compared to men within the 10th to 90th percentile (hazard ratio [HR], 1.60; 95% confidence interval [CI], 1.08-2.36). No consistent associations were seen in cause-specific mortality analyses.CONCLUSION: Our study showed that higher mortality rates were seen among the men who had the most pronounced age-related decline in T, independent of their baseline T levels.

KW - Journal Article

U2 - 10.1530/EJE-17-0280

DO - 10.1530/EJE-17-0280

M3 - Journal article

C2 - 29066571

VL - 178

SP - 121

EP - 128

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

ER -