TY - JOUR

T1 - Intake of fish oil during pregnancy and adiposity in 19-y-old offspring

T2 - Follow-up on a randomized controlled trial

AU - Rytter, Dorte

AU - Bech, Bodil H.

AU - Christensen, Jeppe H.

AU - Schmidt, Erik B.

AU - Henriksen, Tine B.

AU - Olsen, Sjurdur F.

PY - 2011

Y1 - 2011

N2 - Background: It is well established that obesity tends to track from early childhood into adult life. Studies in experimental animals have suggested that changes in the peri- and early postnatal intake of n23 (omega-3) polyunsaturated acids can affect the development of obesity in adult life. Objective: The aim of the current study was to investigate the effect of daily supplementation with 2.7 g long-chain n-3 fatty acids during the third trimester of pregnancy on adiposity in 19-y-old offspring. Design: The study was based on follow-up of a randomized controlled trial from 1990, in which 533 pregnant women were randomly assigned to receive fish oil, olive oil, or no oil. At ∼19 y of age, the offspring of subjects from the randomized controlled trial were invited to undergo a physical examination, including anthropometric measurements and fasting blood sampling. The blood sample was analyzed for insulin, glucose, glycated hemoglobin, leptin, adiponectin, insulin-like growth factor I, and high-sensitivity C-reactive protein. Multiple linear regression modeling, adjusted for sex, smoking, and parental overweight, was used to estimate the effect of fish oil relative to that of olive oil on BMI (in kg/m 2), waist circumference, and biochemical measures. Results: A total of 243 of the offspring were followed up. We found no difference between the fish-oil and olive oil groups in BMI (0.13; -0.92, 1.17) or waist circumference (0.7 cm; -2.1, 3.4 cm). Overall, results of the biochemical analyses supported the finding of no difference between the groups. Conclusion: We detected no effect of fish-oil supplementation during pregnancy on offspring adiposity in adolescence.

AB - Background: It is well established that obesity tends to track from early childhood into adult life. Studies in experimental animals have suggested that changes in the peri- and early postnatal intake of n23 (omega-3) polyunsaturated acids can affect the development of obesity in adult life. Objective: The aim of the current study was to investigate the effect of daily supplementation with 2.7 g long-chain n-3 fatty acids during the third trimester of pregnancy on adiposity in 19-y-old offspring. Design: The study was based on follow-up of a randomized controlled trial from 1990, in which 533 pregnant women were randomly assigned to receive fish oil, olive oil, or no oil. At ∼19 y of age, the offspring of subjects from the randomized controlled trial were invited to undergo a physical examination, including anthropometric measurements and fasting blood sampling. The blood sample was analyzed for insulin, glucose, glycated hemoglobin, leptin, adiponectin, insulin-like growth factor I, and high-sensitivity C-reactive protein. Multiple linear regression modeling, adjusted for sex, smoking, and parental overweight, was used to estimate the effect of fish oil relative to that of olive oil on BMI (in kg/m 2), waist circumference, and biochemical measures. Results: A total of 243 of the offspring were followed up. We found no difference between the fish-oil and olive oil groups in BMI (0.13; -0.92, 1.17) or waist circumference (0.7 cm; -2.1, 3.4 cm). Overall, results of the biochemical analyses supported the finding of no difference between the groups. Conclusion: We detected no effect of fish-oil supplementation during pregnancy on offspring adiposity in adolescence.

U2 - 10.3945/ajcn.111.014969

DO - 10.3945/ajcn.111.014969

M3 - Journal article

C2 - 21775563

AN - SCOPUS:80051965135

VL - 94

SP - 701

EP - 708

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 3

ER -