Lipidomic profiles, lipid trajectories and clinical biomarkers in female elite endurance athletes
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Lipidomic profiles, lipid trajectories and clinical biomarkers in female elite endurance athletes. / Varga, Tibor V.; Ali, Ashfaq; Herrera, Jose A.R.; Ahonen, Linda L.; Mattila, Ismo M.; Al-Sari, Naba H.; Legido-Quigley, Cristina; Skouby, Sven; Brunak, Søren; Tornberg, Åsa B.
In: Scientific Reports, Vol. 10, 2349, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Lipidomic profiles, lipid trajectories and clinical biomarkers in female elite endurance athletes
AU - Varga, Tibor V.
AU - Ali, Ashfaq
AU - Herrera, Jose A.R.
AU - Ahonen, Linda L.
AU - Mattila, Ismo M.
AU - Al-Sari, Naba H.
AU - Legido-Quigley, Cristina
AU - Skouby, Sven
AU - Brunak, Søren
AU - Tornberg, Åsa B.
PY - 2020
Y1 - 2020
N2 - We assessed whether blood lipid metabolites and their changes associate with various cardiometabolic, endocrine, bone- and energy-related comorbidities of Relative Energy Deficiency in Sport (RED-S) in female elite endurance athletes. Thirty-eight Scandinavian female elite athletes underwent a day-long exercise test. Five blood samples were obtained during the day - at fasting state and before and after two standardized exercise tests. Clinical biomarkers were assessed at fasting state, while untargeted lipidomics was undertaken using all blood samples. Linear and logistic regression was used to assess associations between lipidomic features and clinical biomarkers. Overrepresentations of findings with P < 0.05 from these association tests were assessed using Fisher’s exact tests. Self-organizing maps and a trajectory clustering algorithm were utilized to identify informative clusters in the population. Twenty associations PFDR < 0.05 were detected between lipidomic features and clinical biomarkers. Notably, cortisol demonstrated an overrepresentation of associations with P < 0.05 compared to other traits (PFisher = 1.9×10−14). Mean lipid trajectories were created for 201 named features for the cohort and subsequently by stratifying participants by their energy availability and menstrual dysfunction status. This exploratory analysis of lipid trajectories indicates that participants with menstrual dysfunction might have decreased adaptive response to exercise interventions.
AB - We assessed whether blood lipid metabolites and their changes associate with various cardiometabolic, endocrine, bone- and energy-related comorbidities of Relative Energy Deficiency in Sport (RED-S) in female elite endurance athletes. Thirty-eight Scandinavian female elite athletes underwent a day-long exercise test. Five blood samples were obtained during the day - at fasting state and before and after two standardized exercise tests. Clinical biomarkers were assessed at fasting state, while untargeted lipidomics was undertaken using all blood samples. Linear and logistic regression was used to assess associations between lipidomic features and clinical biomarkers. Overrepresentations of findings with P < 0.05 from these association tests were assessed using Fisher’s exact tests. Self-organizing maps and a trajectory clustering algorithm were utilized to identify informative clusters in the population. Twenty associations PFDR < 0.05 were detected between lipidomic features and clinical biomarkers. Notably, cortisol demonstrated an overrepresentation of associations with P < 0.05 compared to other traits (PFisher = 1.9×10−14). Mean lipid trajectories were created for 201 named features for the cohort and subsequently by stratifying participants by their energy availability and menstrual dysfunction status. This exploratory analysis of lipid trajectories indicates that participants with menstrual dysfunction might have decreased adaptive response to exercise interventions.
U2 - 10.1038/s41598-020-59127-8
DO - 10.1038/s41598-020-59127-8
M3 - Journal article
C2 - 32047202
AN - SCOPUS:85079335528
VL - 10
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 2349
ER -
ID: 238002094