Long- term remission status in pediatric obsessive-compulsive disorder: Evaluating the predictive value of symptom severity after treatment

Research output: Contribution to journalJournal articleResearchpeer-review


  • Fulltext

    Final published version, 489 KB, PDF document

  • Sanne Jensen
  • Mortensen, Erik Lykke
  • Gudmundur Skarphedinsson
  • David R. M. A. Hojgaard
  • Katja A. Hybel
  • Judith B. Nissen
  • Tord Ivarsson
  • Bernhard Weidle
  • Nor C. Torp
  • Per H. Thomsen

It is unknown if long-term remission for pediatric obsessive-compulsive disorder (OCD) patients is associated with post-treatment OCD symptom severity. The aim of the present study was to evaluate if post-treatment symptom severity cut-offs can discriminate remitters from non-remitters in pediatric OCD patients during three years of follow-up. All participants (N = 269) from the Nordic Long-term OCD Treatment Study (Nor-dLOTS) undergoing stepped-care treatment were included. Patients were rated with the Clinical Global Impression - Severity Scale (CGI-S) one (n = 186), two (n = 167), and three years (n = 166) after first-line cognitive-behavioral therapy. Post-treatment symptom severity scores as well as percentage reductions during treatment evaluated with the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) were analyzed using receiver operating characteristics according to the CGI-S remission scores (< 2) at follow-up. Post-treatment CY-BOCS severity scores acceptably discriminated remitters from non-remitters at one-year follow-up, but poorly for the two-and three-year follow-up. Severity percentage reduction during treatment did not discriminate remis-sion status acceptably at any follow-up point. Post-treatment OCD symptom severity status seems to have little discriminative value for long-term remission status in pediatric patients. Further research is warranted to detect post-treatment factors of prognostic value.

Original languageEnglish
Article number114906
JournalPsychiatry Research
Number of pages9
Publication statusPublished - 2022

    Research areas

  • Stepped -care treatment, Long-term study, Clinical assessment, Remission, Children and adolescents, Children?s Yale-brown obsessive-compulsive, Clinical global impression scale, COGNITIVE-BEHAVIOR THERAPY, SIGNAL-DETECTION ANALYSIS, DEFINING TREATMENT RESPONSE, FOLLOW-UP, PSYCHOMETRIC EVALUATION, CHILDREN, OCD, NONRESPONDERS, RELIABILITY, ADOLESCENTS

ID: 325637881