Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort

Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study

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Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort : ELAPSE study. / Andersen, Zorana J; Zhang, Jiawei; Jørgensen, Jeanette T; Samoli, Evangelia; Liu, Shuo; Chen, Jie; Strak, Maciej; Wolf, Kathrin; Weinmayr, Gudrun; Rodopolou, Sophia; Remfry, Elizabeth; de Hoogh, Kees; Bellander, Tom; Brandt, Jørgen; Concin, Hans; Zitt, Emanuel; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hoffmann, Barbara; Hvidtfeldt, Ulla A; Monique Verschuren, W M; Jöckel, Karl-Heinz; So, Rina; Cole-Hunter, Tom; Mehta, Amar J; Mortensen, Laust H; Ketzel, Matthias; Lager, Anton; Leander, Karin; Ljungman, Petter; Severi, Gianluca; Boutron-Ruault, Marie-Christine; Magnusson, Patrik K E; Nagel, Gabriele; Pershagen, Göran; Peters, Annette; Rizzuto, Debora; van der Schouw, Yvonne T; Schramm, Sara; Stafoggia, Massimo; Katsouyanni, Klea; Brunekreef, Bert; Hoek, Gerard; Lim, Youn-Hee.

In: Environment International, Vol. 170, 107581, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Andersen, ZJ, Zhang, J, Jørgensen, JT, Samoli, E, Liu, S, Chen, J, Strak, M, Wolf, K, Weinmayr, G, Rodopolou, S, Remfry, E, de Hoogh, K, Bellander, T, Brandt, J, Concin, H, Zitt, E, Fecht, D, Forastiere, F, Gulliver, J, Hoffmann, B, Hvidtfeldt, UA, Monique Verschuren, WM, Jöckel, K-H, So, R, Cole-Hunter, T, Mehta, AJ, Mortensen, LH, Ketzel, M, Lager, A, Leander, K, Ljungman, P, Severi, G, Boutron-Ruault, M-C, Magnusson, PKE, Nagel, G, Pershagen, G, Peters, A, Rizzuto, D, van der Schouw, YT, Schramm, S, Stafoggia, M, Katsouyanni, K, Brunekreef, B, Hoek, G & Lim, Y-H 2022, 'Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study', Environment International, vol. 170, 107581. https://doi.org/10.1016/j.envint.2022.107581

APA

Andersen, Z. J., Zhang, J., Jørgensen, J. T., Samoli, E., Liu, S., Chen, J., Strak, M., Wolf, K., Weinmayr, G., Rodopolou, S., Remfry, E., de Hoogh, K., Bellander, T., Brandt, J., Concin, H., Zitt, E., Fecht, D., Forastiere, F., Gulliver, J., ... Lim, Y-H. (2022). Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study. Environment International, 170, [107581]. https://doi.org/10.1016/j.envint.2022.107581

Vancouver

Andersen ZJ, Zhang J, Jørgensen JT, Samoli E, Liu S, Chen J et al. Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study. Environment International. 2022;170. 107581. https://doi.org/10.1016/j.envint.2022.107581

Author

Andersen, Zorana J ; Zhang, Jiawei ; Jørgensen, Jeanette T ; Samoli, Evangelia ; Liu, Shuo ; Chen, Jie ; Strak, Maciej ; Wolf, Kathrin ; Weinmayr, Gudrun ; Rodopolou, Sophia ; Remfry, Elizabeth ; de Hoogh, Kees ; Bellander, Tom ; Brandt, Jørgen ; Concin, Hans ; Zitt, Emanuel ; Fecht, Daniela ; Forastiere, Francesco ; Gulliver, John ; Hoffmann, Barbara ; Hvidtfeldt, Ulla A ; Monique Verschuren, W M ; Jöckel, Karl-Heinz ; So, Rina ; Cole-Hunter, Tom ; Mehta, Amar J ; Mortensen, Laust H ; Ketzel, Matthias ; Lager, Anton ; Leander, Karin ; Ljungman, Petter ; Severi, Gianluca ; Boutron-Ruault, Marie-Christine ; Magnusson, Patrik K E ; Nagel, Gabriele ; Pershagen, Göran ; Peters, Annette ; Rizzuto, Debora ; van der Schouw, Yvonne T ; Schramm, Sara ; Stafoggia, Massimo ; Katsouyanni, Klea ; Brunekreef, Bert ; Hoek, Gerard ; Lim, Youn-Hee. / Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort : ELAPSE study. In: Environment International. 2022 ; Vol. 170.

Bibtex

@article{e8a71e5639894bdc8222843cb1ccd003,

title = "Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study",

abstract = "Ambient air pollution is an established risk factor for premature mortality from chronic cardiovascular, respiratory and metabolic diseases, while evidence on neurodegenerative diseases and psychiatric disorders remains limited. We examined the association between long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in seven European cohorts. Within the multicenter project 'Effects of Low-Level Air Pollution: A Study in Europe' (ELAPSE), we pooled data from seven European cohorts from six countries. Based on the residential addresses, annual mean levels of fine particulate matter (PM 2.5), nitrogen dioxide (NO 2), black carbon (BC), ozone (O 3), and 8 PM 2.5 components were estimated using Europe-wide hybrid land-use regression models. We applied stratified Cox proportional hazard models to investigate the associations between air pollution and mortality from dementia, psychiatric disorders, and suicide. Of 271,720 participants, 900 died from dementia, 241 from psychiatric disorders, and 164 from suicide, during a mean follow-up of 19.7 years. In fully adjusted models, we observed positive associations of NO 2 (hazard ratio [HR] = 1.38; 95 % confidence interval [CI]: 1.13, 1.70 per 10 µg/m 3), PM 2.5 (HR = 1.29; 95 % CI: 0.98, 1.71 per 5 µg/m 3), and BC (HR = 1.37; 95 % CI: 1.11, 1.69 per 0.5 × 10 -5/m) with psychiatric disorders mortality, as well as with suicide (NO 2: HR = 1.13 [95 % CI: 0.92, 1.38]; PM 2.5: HR = 1.19 [95 % CI: 0.76, 1.87]; BC: HR = 1.08 [95 % CI: 0.87, 1.35]), and no association with dementia mortality. We did not detect any positive associations of O 3 and 8 PM 2.5 components with any of the three mortality outcomes. Long-term exposure to NO 2, PM 2.5, and BC may lead to premature mortality from psychiatric disorders and suicide. ",

author = "Andersen, {Zorana J} and Jiawei Zhang and J{\o}rgensen, {Jeanette T} and Evangelia Samoli and Shuo Liu and Jie Chen and Maciej Strak and Kathrin Wolf and Gudrun Weinmayr and Sophia Rodopolou and Elizabeth Remfry and {de Hoogh}, Kees and Tom Bellander and J{\o}rgen Brandt and Hans Concin and Emanuel Zitt and Daniela Fecht and Francesco Forastiere and John Gulliver and Barbara Hoffmann and Hvidtfeldt, {Ulla A} and {Monique Verschuren}, {W M} and Karl-Heinz J{\"o}ckel and Rina So and Tom Cole-Hunter and Mehta, {Amar J} and Mortensen, {Laust H} and Matthias Ketzel and Anton Lager and Karin Leander and Petter Ljungman and Gianluca Severi and Marie-Christine Boutron-Ruault and Magnusson, {Patrik K E} and Gabriele Nagel and G{\"o}ran Pershagen and Annette Peters and Debora Rizzuto and {van der Schouw}, {Yvonne T} and Sara Schramm and Massimo Stafoggia and Klea Katsouyanni and Bert Brunekreef and Gerard Hoek and Youn-Hee Lim",

year = "2022",

doi = "10.1016/j.envint.2022.107581",

language = "English",

volume = "170",

journal = "Environment international",

issn = "0160-4120",

publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort

T2 - ELAPSE study

AU - Andersen, Zorana J

AU - Zhang, Jiawei

AU - Jørgensen, Jeanette T

AU - Samoli, Evangelia

AU - Liu, Shuo

AU - Chen, Jie

AU - Strak, Maciej

AU - Wolf, Kathrin

AU - Weinmayr, Gudrun

AU - Rodopolou, Sophia

AU - Remfry, Elizabeth

AU - de Hoogh, Kees

AU - Bellander, Tom

AU - Brandt, Jørgen

AU - Concin, Hans

AU - Zitt, Emanuel

AU - Fecht, Daniela

AU - Forastiere, Francesco

AU - Gulliver, John

AU - Hoffmann, Barbara

AU - Hvidtfeldt, Ulla A

AU - Monique Verschuren, W M

AU - Jöckel, Karl-Heinz

AU - So, Rina

AU - Cole-Hunter, Tom

AU - Mehta, Amar J

AU - Mortensen, Laust H

AU - Ketzel, Matthias

AU - Lager, Anton

AU - Leander, Karin

AU - Ljungman, Petter

AU - Severi, Gianluca

AU - Boutron-Ruault, Marie-Christine

AU - Magnusson, Patrik K E

AU - Nagel, Gabriele

AU - Pershagen, Göran

AU - Peters, Annette

AU - Rizzuto, Debora

AU - van der Schouw, Yvonne T

AU - Schramm, Sara

AU - Stafoggia, Massimo

AU - Katsouyanni, Klea

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Lim, Youn-Hee

PY - 2022

Y1 - 2022

N2 - Ambient air pollution is an established risk factor for premature mortality from chronic cardiovascular, respiratory and metabolic diseases, while evidence on neurodegenerative diseases and psychiatric disorders remains limited. We examined the association between long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in seven European cohorts. Within the multicenter project 'Effects of Low-Level Air Pollution: A Study in Europe' (ELAPSE), we pooled data from seven European cohorts from six countries. Based on the residential addresses, annual mean levels of fine particulate matter (PM 2.5), nitrogen dioxide (NO 2), black carbon (BC), ozone (O 3), and 8 PM 2.5 components were estimated using Europe-wide hybrid land-use regression models. We applied stratified Cox proportional hazard models to investigate the associations between air pollution and mortality from dementia, psychiatric disorders, and suicide. Of 271,720 participants, 900 died from dementia, 241 from psychiatric disorders, and 164 from suicide, during a mean follow-up of 19.7 years. In fully adjusted models, we observed positive associations of NO 2 (hazard ratio [HR] = 1.38; 95 % confidence interval [CI]: 1.13, 1.70 per 10 µg/m 3), PM 2.5 (HR = 1.29; 95 % CI: 0.98, 1.71 per 5 µg/m 3), and BC (HR = 1.37; 95 % CI: 1.11, 1.69 per 0.5 × 10 -5/m) with psychiatric disorders mortality, as well as with suicide (NO 2: HR = 1.13 [95 % CI: 0.92, 1.38]; PM 2.5: HR = 1.19 [95 % CI: 0.76, 1.87]; BC: HR = 1.08 [95 % CI: 0.87, 1.35]), and no association with dementia mortality. We did not detect any positive associations of O 3 and 8 PM 2.5 components with any of the three mortality outcomes. Long-term exposure to NO 2, PM 2.5, and BC may lead to premature mortality from psychiatric disorders and suicide.

AB - Ambient air pollution is an established risk factor for premature mortality from chronic cardiovascular, respiratory and metabolic diseases, while evidence on neurodegenerative diseases and psychiatric disorders remains limited. We examined the association between long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in seven European cohorts. Within the multicenter project 'Effects of Low-Level Air Pollution: A Study in Europe' (ELAPSE), we pooled data from seven European cohorts from six countries. Based on the residential addresses, annual mean levels of fine particulate matter (PM 2.5), nitrogen dioxide (NO 2), black carbon (BC), ozone (O 3), and 8 PM 2.5 components were estimated using Europe-wide hybrid land-use regression models. We applied stratified Cox proportional hazard models to investigate the associations between air pollution and mortality from dementia, psychiatric disorders, and suicide. Of 271,720 participants, 900 died from dementia, 241 from psychiatric disorders, and 164 from suicide, during a mean follow-up of 19.7 years. In fully adjusted models, we observed positive associations of NO 2 (hazard ratio [HR] = 1.38; 95 % confidence interval [CI]: 1.13, 1.70 per 10 µg/m 3), PM 2.5 (HR = 1.29; 95 % CI: 0.98, 1.71 per 5 µg/m 3), and BC (HR = 1.37; 95 % CI: 1.11, 1.69 per 0.5 × 10 -5/m) with psychiatric disorders mortality, as well as with suicide (NO 2: HR = 1.13 [95 % CI: 0.92, 1.38]; PM 2.5: HR = 1.19 [95 % CI: 0.76, 1.87]; BC: HR = 1.08 [95 % CI: 0.87, 1.35]), and no association with dementia mortality. We did not detect any positive associations of O 3 and 8 PM 2.5 components with any of the three mortality outcomes. Long-term exposure to NO 2, PM 2.5, and BC may lead to premature mortality from psychiatric disorders and suicide.

U2 - 10.1016/j.envint.2022.107581

DO - 10.1016/j.envint.2022.107581

M3 - Journal article

C2 - 36244228

VL - 170

JO - Environment international

JF - Environment international

SN - 0160-4120

M1 - 107581

ER -

ID: 324591326

Department of Public Health