Mannan-binding lectin and healing of a radiation-induced chronic ulcer--a case report on mannan-binding lectin replacement therapy
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Mannan-binding lectin and healing of a radiation-induced chronic ulcer--a case report on mannan-binding lectin replacement therapy. / Maaløe, Nanna; Bonde, C; Laursen, I; Christiansen, M.; Hölmich, L R.
In: Journal of plastic, reconstructive & aesthetic surgery : JPRAS, Vol. 64, No. 6, 06.2011, p. e146-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Mannan-binding lectin and healing of a radiation-induced chronic ulcer--a case report on mannan-binding lectin replacement therapy
AU - Maaløe, Nanna
AU - Bonde, C
AU - Laursen, I
AU - Christiansen, M.
AU - Hölmich, L R
N1 - Copyright © 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
PY - 2011/6
Y1 - 2011/6
N2 - Mannan-binding lectin is an important component of innate immunity, and insufficiency is associated with several clinical disorders. Recently, experimental replacement therapy with plasma-derived mannan-binding lectin has become an option. The current article presents the case of a patient with an insufficient level of mannan-binding lectin and a chronic radiation-induced ulcer following the treatment of breast cancer. After 15 months of initially conservative treatment and thereafter plastic surgery, the healing was still impaired with necrosis in the periphery of the ulcer. Immunological work-up of the patient revealed pronounced insufficiency of mannan-binding lectin. Following a 6-week experimental intravenous treatment with mannan-binding lectin purified from human plasma, that is, 0.2-0.3 mg mannan-binding lectin per kg body weight twice a week, the defect was completely healed. We suggest that deficiency of mannan-binding lectin can explain cases of otherwise unexplained impaired healing, and that replacement therapy is considered in such cases.
AB - Mannan-binding lectin is an important component of innate immunity, and insufficiency is associated with several clinical disorders. Recently, experimental replacement therapy with plasma-derived mannan-binding lectin has become an option. The current article presents the case of a patient with an insufficient level of mannan-binding lectin and a chronic radiation-induced ulcer following the treatment of breast cancer. After 15 months of initially conservative treatment and thereafter plastic surgery, the healing was still impaired with necrosis in the periphery of the ulcer. Immunological work-up of the patient revealed pronounced insufficiency of mannan-binding lectin. Following a 6-week experimental intravenous treatment with mannan-binding lectin purified from human plasma, that is, 0.2-0.3 mg mannan-binding lectin per kg body weight twice a week, the defect was completely healed. We suggest that deficiency of mannan-binding lectin can explain cases of otherwise unexplained impaired healing, and that replacement therapy is considered in such cases.
KW - Breast Neoplasms
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Injections, Intravenous
KW - Mannose-Binding Lectin
KW - Middle Aged
KW - Radiation Injuries
KW - Ulcer
KW - Wound Healing
U2 - 10.1016/j.bjps.2011.01.013
DO - 10.1016/j.bjps.2011.01.013
M3 - Journal article
C2 - 21353657
VL - 64
SP - e146-8
JO - Journal of plastic, reconstructive & aesthetic surgery : JPRAS
JF - Journal of plastic, reconstructive & aesthetic surgery : JPRAS
SN - 1748-6815
IS - 6
ER -
ID: 130530166