Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation. / Sammallahti, Sara; Cortes Hidalgo, Andrea P.; Tuominen, Samuli; Malmberg, Anni; Mulder, Rosa H.; Brunst, Kelly J.; Alemany, Silvia; McBride, Nancy S.; Yousefi, Paul; Heiss, Jonathan A.; McRae, Nia; Page, Christian M.; Jin, Jianping; Pesce, Giancarlo; Caramaschi, Doretta; Rifas-Shiman, Sheryl L.; Koen, Nastassja; Adams, Charleen D.; Magnus, Maria C.; Baiz, Nour; Ratanatharathorn, Andrew; Czamara, Darina; Haberg, Siri E.; Colicino, Elena; Baccarelli, Andrea A.; Cardenas, Andres; DeMeo, Dawn L.; Lawlor, Deborah A.; Relton, Caroline L.; Felix, Janine F.; van IJzendoorn, Marinus H.; Bakermans-Kranenburg, Marian J.; Kajantie, Eero; Raikkonen, Katri; Sunyer, Jordi; Sharp, Gemma C.; Houtepen, Lotte C.; Nohr, Ellen A.; Sørensen, Thorkild I.A.; Tellez-Rojo, Martha M.; Wright, Robert O.; Annesi-Maesano, Isabella; Wright, John; Hivert, Marie-France; Wright, Rosalind J.; Zar, Heather J.; Stein, Dan J.; London, Stephanie J.; Cecil, Charlotte A. M.; Tiemeier, Henning; Lahti, Jari.

In: Molecular Psychiatry, Vol. 26, 2021, p. 1832–1845.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sammallahti, S, Cortes Hidalgo, AP, Tuominen, S, Malmberg, A, Mulder, RH, Brunst, KJ, Alemany, S, McBride, NS, Yousefi, P, Heiss, JA, McRae, N, Page, CM, Jin, J, Pesce, G, Caramaschi, D, Rifas-Shiman, SL, Koen, N, Adams, CD, Magnus, MC, Baiz, N, Ratanatharathorn, A, Czamara, D, Haberg, SE, Colicino, E, Baccarelli, AA, Cardenas, A, DeMeo, DL, Lawlor, DA, Relton, CL, Felix, JF, van IJzendoorn, MH, Bakermans-Kranenburg, MJ, Kajantie, E, Raikkonen, K, Sunyer, J, Sharp, GC, Houtepen, LC, Nohr, EA, Sørensen, TIA, Tellez-Rojo, MM, Wright, RO, Annesi-Maesano, I, Wright, J, Hivert, M-F, Wright, RJ, Zar, HJ, Stein, DJ, London, SJ, Cecil, CAM, Tiemeier, H & Lahti, J 2021, 'Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation', Molecular Psychiatry, vol. 26, pp. 1832–1845. https://doi.org/10.1038/s41380-020-00976-0

APA

Sammallahti, S., Cortes Hidalgo, A. P., Tuominen, S., Malmberg, A., Mulder, R. H., Brunst, K. J., Alemany, S., McBride, N. S., Yousefi, P., Heiss, J. A., McRae, N., Page, C. M., Jin, J., Pesce, G., Caramaschi, D., Rifas-Shiman, S. L., Koen, N., Adams, C. D., Magnus, M. C., ... Lahti, J. (2021). Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation. Molecular Psychiatry, 26, 1832–1845. https://doi.org/10.1038/s41380-020-00976-0

Vancouver

Sammallahti S, Cortes Hidalgo AP, Tuominen S, Malmberg A, Mulder RH, Brunst KJ et al. Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation. Molecular Psychiatry. 2021;26:1832–1845. https://doi.org/10.1038/s41380-020-00976-0

Author

Sammallahti, Sara ; Cortes Hidalgo, Andrea P. ; Tuominen, Samuli ; Malmberg, Anni ; Mulder, Rosa H. ; Brunst, Kelly J. ; Alemany, Silvia ; McBride, Nancy S. ; Yousefi, Paul ; Heiss, Jonathan A. ; McRae, Nia ; Page, Christian M. ; Jin, Jianping ; Pesce, Giancarlo ; Caramaschi, Doretta ; Rifas-Shiman, Sheryl L. ; Koen, Nastassja ; Adams, Charleen D. ; Magnus, Maria C. ; Baiz, Nour ; Ratanatharathorn, Andrew ; Czamara, Darina ; Haberg, Siri E. ; Colicino, Elena ; Baccarelli, Andrea A. ; Cardenas, Andres ; DeMeo, Dawn L. ; Lawlor, Deborah A. ; Relton, Caroline L. ; Felix, Janine F. ; van IJzendoorn, Marinus H. ; Bakermans-Kranenburg, Marian J. ; Kajantie, Eero ; Raikkonen, Katri ; Sunyer, Jordi ; Sharp, Gemma C. ; Houtepen, Lotte C. ; Nohr, Ellen A. ; Sørensen, Thorkild I.A. ; Tellez-Rojo, Martha M. ; Wright, Robert O. ; Annesi-Maesano, Isabella ; Wright, John ; Hivert, Marie-France ; Wright, Rosalind J. ; Zar, Heather J. ; Stein, Dan J. ; London, Stephanie J. ; Cecil, Charlotte A. M. ; Tiemeier, Henning ; Lahti, Jari. / Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation. In: Molecular Psychiatry. 2021 ; Vol. 26. pp. 1832–1845.

Bibtex

@article{549c29957ed440d18b4a6c11a8708112,
title = "Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation",
abstract = "Maternal anxiety during pregnancy is associated with adverse foetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered foetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations between maternal anxiety, measured prospectively during pregnancy, and genome-wide DNAm from umbilical cord blood. Sixteen non-overlapping cohorts from 12 independent longitudinal studies of the Pregnancy And Childhood Epigenetics Consortium participated, resulting in a combined dataset of 7243 mother-child dyads. We examined prenatal anxiety in relation to genome-wide DNAm and differentially methylated regions. We observed no association between the general symptoms of anxiety during pregnancy or pregnancy-related anxiety, and DNAm at any of the CpG sites, after multiple-testing correction. Furthermore, we identify no differentially methylated regions associated with maternal anxiety. At the cohort-level, of the 21 associations observed in individual cohorts, none replicated consistently in the other cohorts. In conclusion, contrary to some previous studies proposing cord blood DNAm as a promising potential mechanism explaining the link between maternal anxiety during pregnancy and adverse outcomes in offspring, we found no consistent evidence for any robust associations between maternal anxiety and DNAm in cord blood. Larger studies and analysis of DNAm in other tissues may be needed to establish subtle or subgroup-specific associations between maternal anxiety and the foetal epigenome.",
keywords = "RECEPTOR GENE NR3C1, COHORT PROFILE, EXPOSURE, DEPRESSION, CORTISOL, STRESS, BLOOD, METAANALYSIS, DISCOVERY, UPDATE",
author = "Sara Sammallahti and {Cortes Hidalgo}, {Andrea P.} and Samuli Tuominen and Anni Malmberg and Mulder, {Rosa H.} and Brunst, {Kelly J.} and Silvia Alemany and McBride, {Nancy S.} and Paul Yousefi and Heiss, {Jonathan A.} and Nia McRae and Page, {Christian M.} and Jianping Jin and Giancarlo Pesce and Doretta Caramaschi and Rifas-Shiman, {Sheryl L.} and Nastassja Koen and Adams, {Charleen D.} and Magnus, {Maria C.} and Nour Baiz and Andrew Ratanatharathorn and Darina Czamara and Haberg, {Siri E.} and Elena Colicino and Baccarelli, {Andrea A.} and Andres Cardenas and DeMeo, {Dawn L.} and Lawlor, {Deborah A.} and Relton, {Caroline L.} and Felix, {Janine F.} and {van IJzendoorn}, {Marinus H.} and Bakermans-Kranenburg, {Marian J.} and Eero Kajantie and Katri Raikkonen and Jordi Sunyer and Sharp, {Gemma C.} and Houtepen, {Lotte C.} and Nohr, {Ellen A.} and S{\o}rensen, {Thorkild I.A.} and Tellez-Rojo, {Martha M.} and Wright, {Robert O.} and Isabella Annesi-Maesano and John Wright and Marie-France Hivert and Wright, {Rosalind J.} and Zar, {Heather J.} and Stein, {Dan J.} and London, {Stephanie J.} and Cecil, {Charlotte A. M.} and Henning Tiemeier and Jari Lahti",
year = "2021",
doi = "10.1038/s41380-020-00976-0",
language = "English",
volume = "26",
pages = "1832–1845",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

AU - Sammallahti, Sara

AU - Cortes Hidalgo, Andrea P.

AU - Tuominen, Samuli

AU - Malmberg, Anni

AU - Mulder, Rosa H.

AU - Brunst, Kelly J.

AU - Alemany, Silvia

AU - McBride, Nancy S.

AU - Yousefi, Paul

AU - Heiss, Jonathan A.

AU - McRae, Nia

AU - Page, Christian M.

AU - Jin, Jianping

AU - Pesce, Giancarlo

AU - Caramaschi, Doretta

AU - Rifas-Shiman, Sheryl L.

AU - Koen, Nastassja

AU - Adams, Charleen D.

AU - Magnus, Maria C.

AU - Baiz, Nour

AU - Ratanatharathorn, Andrew

AU - Czamara, Darina

AU - Haberg, Siri E.

AU - Colicino, Elena

AU - Baccarelli, Andrea A.

AU - Cardenas, Andres

AU - DeMeo, Dawn L.

AU - Lawlor, Deborah A.

AU - Relton, Caroline L.

AU - Felix, Janine F.

AU - van IJzendoorn, Marinus H.

AU - Bakermans-Kranenburg, Marian J.

AU - Kajantie, Eero

AU - Raikkonen, Katri

AU - Sunyer, Jordi

AU - Sharp, Gemma C.

AU - Houtepen, Lotte C.

AU - Nohr, Ellen A.

AU - Sørensen, Thorkild I.A.

AU - Tellez-Rojo, Martha M.

AU - Wright, Robert O.

AU - Annesi-Maesano, Isabella

AU - Wright, John

AU - Hivert, Marie-France

AU - Wright, Rosalind J.

AU - Zar, Heather J.

AU - Stein, Dan J.

AU - London, Stephanie J.

AU - Cecil, Charlotte A. M.

AU - Tiemeier, Henning

AU - Lahti, Jari

PY - 2021

Y1 - 2021

N2 - Maternal anxiety during pregnancy is associated with adverse foetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered foetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations between maternal anxiety, measured prospectively during pregnancy, and genome-wide DNAm from umbilical cord blood. Sixteen non-overlapping cohorts from 12 independent longitudinal studies of the Pregnancy And Childhood Epigenetics Consortium participated, resulting in a combined dataset of 7243 mother-child dyads. We examined prenatal anxiety in relation to genome-wide DNAm and differentially methylated regions. We observed no association between the general symptoms of anxiety during pregnancy or pregnancy-related anxiety, and DNAm at any of the CpG sites, after multiple-testing correction. Furthermore, we identify no differentially methylated regions associated with maternal anxiety. At the cohort-level, of the 21 associations observed in individual cohorts, none replicated consistently in the other cohorts. In conclusion, contrary to some previous studies proposing cord blood DNAm as a promising potential mechanism explaining the link between maternal anxiety during pregnancy and adverse outcomes in offspring, we found no consistent evidence for any robust associations between maternal anxiety and DNAm in cord blood. Larger studies and analysis of DNAm in other tissues may be needed to establish subtle or subgroup-specific associations between maternal anxiety and the foetal epigenome.

AB - Maternal anxiety during pregnancy is associated with adverse foetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered foetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations between maternal anxiety, measured prospectively during pregnancy, and genome-wide DNAm from umbilical cord blood. Sixteen non-overlapping cohorts from 12 independent longitudinal studies of the Pregnancy And Childhood Epigenetics Consortium participated, resulting in a combined dataset of 7243 mother-child dyads. We examined prenatal anxiety in relation to genome-wide DNAm and differentially methylated regions. We observed no association between the general symptoms of anxiety during pregnancy or pregnancy-related anxiety, and DNAm at any of the CpG sites, after multiple-testing correction. Furthermore, we identify no differentially methylated regions associated with maternal anxiety. At the cohort-level, of the 21 associations observed in individual cohorts, none replicated consistently in the other cohorts. In conclusion, contrary to some previous studies proposing cord blood DNAm as a promising potential mechanism explaining the link between maternal anxiety during pregnancy and adverse outcomes in offspring, we found no consistent evidence for any robust associations between maternal anxiety and DNAm in cord blood. Larger studies and analysis of DNAm in other tissues may be needed to establish subtle or subgroup-specific associations between maternal anxiety and the foetal epigenome.

KW - RECEPTOR GENE NR3C1

KW - COHORT PROFILE

KW - EXPOSURE

KW - DEPRESSION

KW - CORTISOL

KW - STRESS

KW - BLOOD

KW - METAANALYSIS

KW - DISCOVERY

KW - UPDATE

U2 - 10.1038/s41380-020-00976-0

DO - 10.1038/s41380-020-00976-0

M3 - Journal article

C2 - 33414500

VL - 26

SP - 1832

EP - 1845

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

ER -

ID: 255778750