Maternal fever during pregnancy and male offspring reproductive health: A longitudinal cohort study in young Danish males

Research output: Contribution to journalJournal articlepeer-review

Standard

Maternal fever during pregnancy and male offspring reproductive health : A longitudinal cohort study in young Danish males. / Dornfeldt, Mette Møller; Andersen, Anne Marie Nybo; Hougaard, Karin Sørig; Ramlau-Hansen, Cecilia Høst; Toft, Gunnar; Bonde, Jens Peter Ellekilde; Hærvig, Katia Keglberg; Petersen, Kajsa Ugelvig; Kofoed, Ane Berger Bungum; Deen, Laura; Tøttenborg, Sandra Søgaard.

In: Andrology, Vol. 11, No. 3, 2023, p. 523-536.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Dornfeldt, MM, Andersen, AMN, Hougaard, KS, Ramlau-Hansen, CH, Toft, G, Bonde, JPE, Hærvig, KK, Petersen, KU, Kofoed, ABB, Deen, L & Tøttenborg, SS 2023, 'Maternal fever during pregnancy and male offspring reproductive health: A longitudinal cohort study in young Danish males', Andrology, vol. 11, no. 3, pp. 523-536. https://doi.org/10.1111/andr.13345

APA

Dornfeldt, M. M., Andersen, A. M. N., Hougaard, K. S., Ramlau-Hansen, C. H., Toft, G., Bonde, J. P. E., Hærvig, K. K., Petersen, K. U., Kofoed, A. B. B., Deen, L., & Tøttenborg, S. S. (2023). Maternal fever during pregnancy and male offspring reproductive health: A longitudinal cohort study in young Danish males. Andrology, 11(3), 523-536. https://doi.org/10.1111/andr.13345

Vancouver

Dornfeldt MM, Andersen AMN, Hougaard KS, Ramlau-Hansen CH, Toft G, Bonde JPE et al. Maternal fever during pregnancy and male offspring reproductive health: A longitudinal cohort study in young Danish males. Andrology. 2023;11(3):523-536. https://doi.org/10.1111/andr.13345

Author

Dornfeldt, Mette Møller ; Andersen, Anne Marie Nybo ; Hougaard, Karin Sørig ; Ramlau-Hansen, Cecilia Høst ; Toft, Gunnar ; Bonde, Jens Peter Ellekilde ; Hærvig, Katia Keglberg ; Petersen, Kajsa Ugelvig ; Kofoed, Ane Berger Bungum ; Deen, Laura ; Tøttenborg, Sandra Søgaard. / Maternal fever during pregnancy and male offspring reproductive health : A longitudinal cohort study in young Danish males. In: Andrology. 2023 ; Vol. 11, No. 3. pp. 523-536.

Bibtex

@article{faf4df4e433841b4809f3f195352be17,
title = "Maternal fever during pregnancy and male offspring reproductive health: A longitudinal cohort study in young Danish males",
abstract = "Background: Maternal fever during pregnancy has been associated with an increased risk of genital malformations, but the implication for long-term reproductive health in the offspring is unknown. Objectives: To investigate associations between timing, duration, and temperature of fetal exposure to maternal fever and sons{\textquoteright} semen quality, testicular volume, and levels of reproductive hormones in early adulthood. Further, to examine whether concurrent use of antipyretics and/or antibiotics modified the effect. Materials and methods: We used the Fetal Programming of Semen Quality cohort consisting of men born to women enrolled in the Danish National Birth Cohort. Self-reported information on maternal fever was collected twice during pregnancy (median 16 and 31 pregnancy weeks) and categorized as any fever during pregnancy, fever during early pregnancy (weeks 1–15), and fever exclusively during late pregnancy (weeks 16–42). Semen quality and concentrations of reproductive hormones were measured at a clinical examination at the age of 18.9 years. We used negative binomial regression to examine the associations, adjusting for maternal age at birth, maternal smoking, family occupational status, and precision variables related to semen quality and hormonal levels, for example, abstinence time. Results: 986 men were included in the study, of which 23% had mothers reporting at least one episode of fever. We found no strong indications of associations between maternal fever during pregnancy and male reproductive health in young men. Concurrent use of antipyretics and antibiotics did not modify the association. Discussion: Strengths include the large sample size, prospectively collected data, and the adjustment for maternal factors during pregnancy and important precision variables. A limitation is the crude self-reported information on maternal fever. Conclusion: We found no evidence to support that timing, duration, or temperature of maternal fever during pregnancy has a long-term impact on semen characteristics, testicular volume, or level of reproductive hormones in male offspring.",
keywords = "antibiotics, antipyretics, maternal fever, prenatal exposure, reproductive hormones, semen quality",
author = "Dornfeldt, {Mette M{\o}ller} and Andersen, {Anne Marie Nybo} and Hougaard, {Karin S{\o}rig} and Ramlau-Hansen, {Cecilia H{\o}st} and Gunnar Toft and Bonde, {Jens Peter Ellekilde} and H{\ae}rvig, {Katia Keglberg} and Petersen, {Kajsa Ugelvig} and Kofoed, {Ane Berger Bungum} and Laura Deen and T{\o}ttenborg, {Sandra S{\o}gaard}",
note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Andrology published by Wiley Periodicals LLC on behalf of American Society of Andrology and European Academy of Andrology.",
year = "2023",
doi = "10.1111/andr.13345",
language = "English",
volume = "11",
pages = "523--536",
journal = "Journal of Andrology",
issn = "2047-2919",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Maternal fever during pregnancy and male offspring reproductive health

T2 - A longitudinal cohort study in young Danish males

AU - Dornfeldt, Mette Møller

AU - Andersen, Anne Marie Nybo

AU - Hougaard, Karin Sørig

AU - Ramlau-Hansen, Cecilia Høst

AU - Toft, Gunnar

AU - Bonde, Jens Peter Ellekilde

AU - Hærvig, Katia Keglberg

AU - Petersen, Kajsa Ugelvig

AU - Kofoed, Ane Berger Bungum

AU - Deen, Laura

AU - Tøttenborg, Sandra Søgaard

N1 - Publisher Copyright: © 2022 The Authors. Andrology published by Wiley Periodicals LLC on behalf of American Society of Andrology and European Academy of Andrology.

PY - 2023

Y1 - 2023

N2 - Background: Maternal fever during pregnancy has been associated with an increased risk of genital malformations, but the implication for long-term reproductive health in the offspring is unknown. Objectives: To investigate associations between timing, duration, and temperature of fetal exposure to maternal fever and sons’ semen quality, testicular volume, and levels of reproductive hormones in early adulthood. Further, to examine whether concurrent use of antipyretics and/or antibiotics modified the effect. Materials and methods: We used the Fetal Programming of Semen Quality cohort consisting of men born to women enrolled in the Danish National Birth Cohort. Self-reported information on maternal fever was collected twice during pregnancy (median 16 and 31 pregnancy weeks) and categorized as any fever during pregnancy, fever during early pregnancy (weeks 1–15), and fever exclusively during late pregnancy (weeks 16–42). Semen quality and concentrations of reproductive hormones were measured at a clinical examination at the age of 18.9 years. We used negative binomial regression to examine the associations, adjusting for maternal age at birth, maternal smoking, family occupational status, and precision variables related to semen quality and hormonal levels, for example, abstinence time. Results: 986 men were included in the study, of which 23% had mothers reporting at least one episode of fever. We found no strong indications of associations between maternal fever during pregnancy and male reproductive health in young men. Concurrent use of antipyretics and antibiotics did not modify the association. Discussion: Strengths include the large sample size, prospectively collected data, and the adjustment for maternal factors during pregnancy and important precision variables. A limitation is the crude self-reported information on maternal fever. Conclusion: We found no evidence to support that timing, duration, or temperature of maternal fever during pregnancy has a long-term impact on semen characteristics, testicular volume, or level of reproductive hormones in male offspring.

AB - Background: Maternal fever during pregnancy has been associated with an increased risk of genital malformations, but the implication for long-term reproductive health in the offspring is unknown. Objectives: To investigate associations between timing, duration, and temperature of fetal exposure to maternal fever and sons’ semen quality, testicular volume, and levels of reproductive hormones in early adulthood. Further, to examine whether concurrent use of antipyretics and/or antibiotics modified the effect. Materials and methods: We used the Fetal Programming of Semen Quality cohort consisting of men born to women enrolled in the Danish National Birth Cohort. Self-reported information on maternal fever was collected twice during pregnancy (median 16 and 31 pregnancy weeks) and categorized as any fever during pregnancy, fever during early pregnancy (weeks 1–15), and fever exclusively during late pregnancy (weeks 16–42). Semen quality and concentrations of reproductive hormones were measured at a clinical examination at the age of 18.9 years. We used negative binomial regression to examine the associations, adjusting for maternal age at birth, maternal smoking, family occupational status, and precision variables related to semen quality and hormonal levels, for example, abstinence time. Results: 986 men were included in the study, of which 23% had mothers reporting at least one episode of fever. We found no strong indications of associations between maternal fever during pregnancy and male reproductive health in young men. Concurrent use of antipyretics and antibiotics did not modify the association. Discussion: Strengths include the large sample size, prospectively collected data, and the adjustment for maternal factors during pregnancy and important precision variables. A limitation is the crude self-reported information on maternal fever. Conclusion: We found no evidence to support that timing, duration, or temperature of maternal fever during pregnancy has a long-term impact on semen characteristics, testicular volume, or level of reproductive hormones in male offspring.

KW - antibiotics

KW - antipyretics

KW - maternal fever

KW - prenatal exposure

KW - reproductive hormones

KW - semen quality

U2 - 10.1111/andr.13345

DO - 10.1111/andr.13345

M3 - Journal article

C2 - 36415019

AN - SCOPUS:85144470949

VL - 11

SP - 523

EP - 536

JO - Journal of Andrology

JF - Journal of Andrology

SN - 2047-2919

IS - 3

ER -

ID: 332198576