Maternal pre-pregnancy overweight and infertility in sons and daughters: A cohort study
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Maternal pre-pregnancy overweight and infertility in sons and daughters : A cohort study. / Arendt, Linn H.; Høyer, Birgit B.; Kreilgaard, Anne F.; Bech, Bodil H.; Toft, Gunnar; Hougaard, Karin S.; Bonde, Jens P.; Olsen, Jørn; Ramlau-Hansen, Cecilia H.
In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 100, No. 5, 2021, p. 843-849.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Maternal pre-pregnancy overweight and infertility in sons and daughters
T2 - A cohort study
AU - Arendt, Linn H.
AU - Høyer, Birgit B.
AU - Kreilgaard, Anne F.
AU - Bech, Bodil H.
AU - Toft, Gunnar
AU - Hougaard, Karin S.
AU - Bonde, Jens P.
AU - Olsen, Jørn
AU - Ramlau-Hansen, Cecilia H.
PY - 2021
Y1 - 2021
N2 - Introduction: Overweight and obesity in pregnancy is increasing worldwide and may harm the developing fetus, including its future reproductive health. We therefore studied the association between in utero exposure to maternal overweight and obesity and infertility in adulthood. No studies have previously assessed this association. Material and methods: We performed a cohort study with 9232 adult sons and daughters whose mothers were enrolled in the Danish Healthy Habits for Two cohort during pregnancy in 1984-87. Participants were sons and daughters followed in the Danish In-Vitro-Fertilization-Register and Danish National Patient Register until February 2018 for diagnoses of infertility. Results: In total, 1203 (13%) sons and daughters were born to mothers with a body mass index (BMI) >25 kg/m2; 871 (9.4%) of the participants were identified as being infertile during follow up. Sons of overweight mothers had slightly increased odds of infertility compared with sons of mothers with normal body weight (BMI 18.5-24.9 kg/m2, adjusted odds ratio 1.4, 95% confidence interval [CI] 1.0-1.9). Cubic spline analyses with continuous BMI levels showed increasing odds with higher levels of BMI; however, for BMI >29 kg/m2 the confidence intervals were too wide to draw conclusions. No association between maternal overweight and infertility was found among daughters (adjusted odds ratio 0.9, 95% CI 0.7-1.2)). Conclusions: Sons born to overweight mothers had higher odds of infertility compared with sons of normal weight mothers. No association between maternal overweight and infertility was observed in daughters. Prevention of overweight during pregnancy may be an important tool to preserve fecundity in future generations.
AB - Introduction: Overweight and obesity in pregnancy is increasing worldwide and may harm the developing fetus, including its future reproductive health. We therefore studied the association between in utero exposure to maternal overweight and obesity and infertility in adulthood. No studies have previously assessed this association. Material and methods: We performed a cohort study with 9232 adult sons and daughters whose mothers were enrolled in the Danish Healthy Habits for Two cohort during pregnancy in 1984-87. Participants were sons and daughters followed in the Danish In-Vitro-Fertilization-Register and Danish National Patient Register until February 2018 for diagnoses of infertility. Results: In total, 1203 (13%) sons and daughters were born to mothers with a body mass index (BMI) >25 kg/m2; 871 (9.4%) of the participants were identified as being infertile during follow up. Sons of overweight mothers had slightly increased odds of infertility compared with sons of mothers with normal body weight (BMI 18.5-24.9 kg/m2, adjusted odds ratio 1.4, 95% confidence interval [CI] 1.0-1.9). Cubic spline analyses with continuous BMI levels showed increasing odds with higher levels of BMI; however, for BMI >29 kg/m2 the confidence intervals were too wide to draw conclusions. No association between maternal overweight and infertility was found among daughters (adjusted odds ratio 0.9, 95% CI 0.7-1.2)). Conclusions: Sons born to overweight mothers had higher odds of infertility compared with sons of normal weight mothers. No association between maternal overweight and infertility was observed in daughters. Prevention of overweight during pregnancy may be an important tool to preserve fecundity in future generations.
KW - cohort study
KW - infertility
KW - male offspring
KW - maternal overweight
KW - pregnancy
KW - prenatal exposure delayed effect
KW - reproductive health
U2 - 10.1111/aogs.14045
DO - 10.1111/aogs.14045
M3 - Journal article
C2 - 33191504
AN - SCOPUS:85099039233
VL - 100
SP - 843
EP - 849
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 5
ER -
ID: 255310127