Maternal underweight and the risk of spontaneous abortion
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Maternal underweight and the risk of spontaneous abortion. / Helgstrand, Stine; Andersen, Anne-Marie Nybo.
In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 84, No. 12, 2005, p. 1197-1201.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Maternal underweight and the risk of spontaneous abortion
AU - Helgstrand, Stine
AU - Andersen, Anne-Marie Nybo
PY - 2005
Y1 - 2005
N2 - BACKGROUND: To evaluate the risk of spontaneous abortion in relation to maternal pre-pregnant underweight. METHODS: The study was designed as a cohort study within the framework of the Danish National Birth Cohort (DNBC). The participants were a total of 23 821 women recruited consecutively to the DNBC from October 1, 1997 to March 31, 1999 and interviewed subsequently. The pregnant women were recruited in first half of pregnancy and interviewed about pre-pregnant body size, obstetric history, exposures in pregnancy, and socio-demographic factors. Pregnancies were followed-up regarding spontaneous abortion. Relative risk of spontaneous abortion was calculated as Hazard Ratios using Cox regression with delayed entry. RESULTS: The outcome measure was spontaneous abortion. The hazard ratio for spontaneous abortion in women with a pre-pregnant body mass index (BMI) below 18.5 was 1.24 (95% confidence limits 0.95-1.63) compared to women with pre-pregnant BMI 18.5-24.9. Women with a BMI of 25 or more had a smaller increase in risk of spontaneous abortion. Adjustment for maternal age, parity, previous miscarriages, and lifestyle factors did not affect the estimates substantially, neither did exclusion of women with metabolic or eating disorders. CONCLUSION: These results indicate that pre-pregnant underweight may affect the risk of spontaneous abortion negatively.
AB - BACKGROUND: To evaluate the risk of spontaneous abortion in relation to maternal pre-pregnant underweight. METHODS: The study was designed as a cohort study within the framework of the Danish National Birth Cohort (DNBC). The participants were a total of 23 821 women recruited consecutively to the DNBC from October 1, 1997 to March 31, 1999 and interviewed subsequently. The pregnant women were recruited in first half of pregnancy and interviewed about pre-pregnant body size, obstetric history, exposures in pregnancy, and socio-demographic factors. Pregnancies were followed-up regarding spontaneous abortion. Relative risk of spontaneous abortion was calculated as Hazard Ratios using Cox regression with delayed entry. RESULTS: The outcome measure was spontaneous abortion. The hazard ratio for spontaneous abortion in women with a pre-pregnant body mass index (BMI) below 18.5 was 1.24 (95% confidence limits 0.95-1.63) compared to women with pre-pregnant BMI 18.5-24.9. Women with a BMI of 25 or more had a smaller increase in risk of spontaneous abortion. Adjustment for maternal age, parity, previous miscarriages, and lifestyle factors did not affect the estimates substantially, neither did exclusion of women with metabolic or eating disorders. CONCLUSION: These results indicate that pre-pregnant underweight may affect the risk of spontaneous abortion negatively.
U2 - 10.1111/j.0001-6349.2005.00706.x
DO - 10.1111/j.0001-6349.2005.00706.x
M3 - Journal article
C2 - 16305708
VL - 84
SP - 1197
EP - 1201
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 12
ER -
ID: 21161858