Matters Arising: Immortal time bias in the analysis of drug prescription trajectories
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Matters Arising : Immortal time bias in the analysis of drug prescription trajectories. / Christensen, Daniel Mølager; Gislason, Gunnar; Gerds, Thomas.
In: npj Digital Medicine, Vol. 5, No. 1, 190, 2022.Research output: Contribution to journal › Comment/debate › Research › peer-review
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TY - JOUR
T1 - Matters Arising
T2 - Immortal time bias in the analysis of drug prescription trajectories
AU - Christensen, Daniel Mølager
AU - Gislason, Gunnar
AU - Gerds, Thomas
PY - 2022
Y1 - 2022
N2 - Aguayo-Orozco et al. [1] report survival differences in patients taking renin-angiotensin system inhibitors depending on the drug prescription trajectories identified through Danish healthcare registries. They found that changing from an initial prescription of an ACE (angiotensin-converting enzyme) inhibitor to an angiotensin receptor blocker (ARB) and vice versa conferred a survival benefit compared to no change using standard statistical tools for survival analysis. They replicated this finding in data from the UK Biobank and concluded that their results may be important when updating treatment guidelines
AB - Aguayo-Orozco et al. [1] report survival differences in patients taking renin-angiotensin system inhibitors depending on the drug prescription trajectories identified through Danish healthcare registries. They found that changing from an initial prescription of an ACE (angiotensin-converting enzyme) inhibitor to an angiotensin receptor blocker (ARB) and vice versa conferred a survival benefit compared to no change using standard statistical tools for survival analysis. They replicated this finding in data from the UK Biobank and concluded that their results may be important when updating treatment guidelines
U2 - 10.1038/s41746-022-00722-6
DO - 10.1038/s41746-022-00722-6
M3 - Comment/debate
C2 - 36813918
AN - SCOPUS:85145371141
VL - 5
JO - npj Digital Medicine
JF - npj Digital Medicine
SN - 2398-6352
IS - 1
M1 - 190
ER -
ID: 332198387