Mercury analysis in hair: Comparability and quality assessment within the transnational COPHES/DEMOCOPHES project
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Mercury analysis in hair : Comparability and quality assessment within the transnational COPHES/DEMOCOPHES project. / Esteban, Marta; Schindler, Birgit K; Jiménez-Guerrero, José A; Koch, Holger M; Angerer, Jürgen; Rivas, Teresa C; Rosado, Montserrat; Gómez, Silvia; Casteleyn, Ludwine; Kolossa-Gehring, Marike; Becker, Kerstin; Bloemen, Louis; Schoeters, Greet; Hond, Elly Den; Sepai, Ovnair; Exley, Karen; Horvat, Milena; Knudsen, Lisbeth E.; Joas, Anke; Joas, Reinhard; Aerts, Dominique; Biot, Pierre; Borošová, Daniela; Davidson, Fred; Dumitrascu, Irina; Fisher, Marc E; Grander, Margaretha; Janasik, Beata; Jones, Kate; Kašparová, Lucie; Larssen, Thorjørn; Naray, Miklos; Nielsen, Flemming; Hohenblum, Philipp; Pinto, Rui; Pirard, Catherine; Plateel, Gregory; Tratnik, Janja; Wittsiepe, Jürgen; Castaño, Argelia; Equas Reference Laboratories.
In: Environmental Research, Vol. 141, 08.2015, p. 24–30.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Mercury analysis in hair
T2 - Comparability and quality assessment within the transnational COPHES/DEMOCOPHES project
AU - Esteban, Marta
AU - Schindler, Birgit K
AU - Jiménez-Guerrero, José A
AU - Koch, Holger M
AU - Angerer, Jürgen
AU - Rivas, Teresa C
AU - Rosado, Montserrat
AU - Gómez, Silvia
AU - Casteleyn, Ludwine
AU - Kolossa-Gehring, Marike
AU - Becker, Kerstin
AU - Bloemen, Louis
AU - Schoeters, Greet
AU - Hond, Elly Den
AU - Sepai, Ovnair
AU - Exley, Karen
AU - Horvat, Milena
AU - Knudsen, Lisbeth E.
AU - Joas, Anke
AU - Joas, Reinhard
AU - Aerts, Dominique
AU - Biot, Pierre
AU - Borošová, Daniela
AU - Davidson, Fred
AU - Dumitrascu, Irina
AU - Fisher, Marc E
AU - Grander, Margaretha
AU - Janasik, Beata
AU - Jones, Kate
AU - Kašparová, Lucie
AU - Larssen, Thorjørn
AU - Naray, Miklos
AU - Nielsen, Flemming
AU - Hohenblum, Philipp
AU - Pinto, Rui
AU - Pirard, Catherine
AU - Plateel, Gregory
AU - Tratnik, Janja
AU - Wittsiepe, Jürgen
AU - Castaño, Argelia
AU - Equas Reference Laboratories, null
N1 - Copyright © 2014 Elsevier Inc. All rights reserved.
PY - 2015/8
Y1 - 2015/8
N2 - Human biomonitoring (HBM) is an effective tool for assessing actual exposure to chemicals that takes into account all routes of intake. Although hair analysis is considered to be an optimal biomarker for assessing mercury exposure, the lack of harmonization as regards sampling and analytical procedures has often limited the comparison of data at national and international level. The European-funded projects COPHES and DEMOCOPHES developed and tested a harmonized European approach to Human Biomonitoring in response to the European Environment and Health Action Plan. Herein we describe the quality assurance program (QAP) for assessing mercury levels in hair samples from more than 1800 mother-child pairs recruited in 17 European countries. To ensure the comparability of the results, standard operating procedures (SOPs) for sampling and for mercury analysis were drafted and distributed to participating laboratories. Training sessions were organized for field workers and four external quality-assessment exercises (ICI/EQUAS), followed by the corresponding web conferences, were organized between March 2011 and February 2012. ICI/EQUAS used native hair samples at two mercury concentration ranges (0.20-0.71 and 0.80-1.63) per exercise. The results revealed relative standard deviations of 7.87-13.55% and 4.04-11.31% for the low and high mercury concentration ranges, respectively. A total of 16 out of 18 participating laboratories the QAP requirements and were allowed to analyze samples from the DEMOCOPHES pilot study. Web conferences after each ICI/EQUAS revealed this to be a new and effective tool for improving analytical performance and increasing capacity building. The procedure developed and tested in COPHES/DEMOCOPHES would be optimal for application on a global scale as regards implementation of the Minamata Convention on Mercury.
AB - Human biomonitoring (HBM) is an effective tool for assessing actual exposure to chemicals that takes into account all routes of intake. Although hair analysis is considered to be an optimal biomarker for assessing mercury exposure, the lack of harmonization as regards sampling and analytical procedures has often limited the comparison of data at national and international level. The European-funded projects COPHES and DEMOCOPHES developed and tested a harmonized European approach to Human Biomonitoring in response to the European Environment and Health Action Plan. Herein we describe the quality assurance program (QAP) for assessing mercury levels in hair samples from more than 1800 mother-child pairs recruited in 17 European countries. To ensure the comparability of the results, standard operating procedures (SOPs) for sampling and for mercury analysis were drafted and distributed to participating laboratories. Training sessions were organized for field workers and four external quality-assessment exercises (ICI/EQUAS), followed by the corresponding web conferences, were organized between March 2011 and February 2012. ICI/EQUAS used native hair samples at two mercury concentration ranges (0.20-0.71 and 0.80-1.63) per exercise. The results revealed relative standard deviations of 7.87-13.55% and 4.04-11.31% for the low and high mercury concentration ranges, respectively. A total of 16 out of 18 participating laboratories the QAP requirements and were allowed to analyze samples from the DEMOCOPHES pilot study. Web conferences after each ICI/EQUAS revealed this to be a new and effective tool for improving analytical performance and increasing capacity building. The procedure developed and tested in COPHES/DEMOCOPHES would be optimal for application on a global scale as regards implementation of the Minamata Convention on Mercury.
U2 - 10.1016/j.envres.2014.11.014
DO - 10.1016/j.envres.2014.11.014
M3 - Journal article
C2 - 25483984
VL - 141
SP - 24
EP - 30
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
ER -
ID: 137756667