TY - JOUR

T1 - Metabolic Obesity Phenotypes and Risk of Lung Cancer

T2 - A Prospective Cohort Study of 450,482 UK Biobank Participants

AU - Shao, Fang

AU - Chen, Yina

AU - Xu, Hongyang

AU - Chen, Xin

AU - Zhou, Jiawei

AU - Wu, Yaqian

AU - Tang, Yingdan

AU - Wang, Zhongtian

AU - Zhang, Ruyang

AU - Lange, Theis

AU - Ma, Hongxia

AU - Hu, Zhibin

AU - Shen, Hongbing

AU - Christiani, David C.

AU - Chen, Feng

AU - Zhao, Yang

AU - You, Dongfang

PY - 2022

Y1 - 2022

N2 - (1) Background: The association between metabolic obesity phenotypes and incident lung cancer (LC) remains unclear. (2) Methods: Based on the combination of baseline BMI categories and metabolic health status, participants were categorized into eight groups: metabolically healthy underweight (MHUW), metabolically unhealthy underweight (MUUW), metabolically healthy normal (MHN), metabolically unhealthy normal (MUN), metabolically healthy overweight (MHOW), metabolically unhealthy overweight (MUOW), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUO). The Cox proportional hazards model and Mendelian randomization (MR) were applied to assess the association between metabolic obesity phenotypes with LC risk. (3) Results: During a median follow-up of 9.1 years, 3654 incident LC patients were confirmed among 450,482 individuals. Compared with participants with MHN, those with MUUW had higher rates of incident LC (hazard ratio (HR) = 3.24, 95% confidence interval (CI) = 1.33-7.87, p = 0.009). MHO and MHOW individuals had a 24% and 18% lower risk of developing LC, respectively (MHO: HR = 0.76, 95% CI = 0.61-0.95, p = 0.02; MHO: HR = 0.82, 95% CI = 0.70-0.96, p = 0.02). No genetic association of metabolic obesity phenotypes and LC risk was observed in MR analysis. (4) Conclusions: In this prospective cohort study, individuals with MHOW and MHO phenotypes were at a lower risk and MUUW were at a higher risk of LC. However, MR failed to reveal any evidence that metabolic obesity phenotypes would be associated with a higher risk of LC.

AB - (1) Background: The association between metabolic obesity phenotypes and incident lung cancer (LC) remains unclear. (2) Methods: Based on the combination of baseline BMI categories and metabolic health status, participants were categorized into eight groups: metabolically healthy underweight (MHUW), metabolically unhealthy underweight (MUUW), metabolically healthy normal (MHN), metabolically unhealthy normal (MUN), metabolically healthy overweight (MHOW), metabolically unhealthy overweight (MUOW), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUO). The Cox proportional hazards model and Mendelian randomization (MR) were applied to assess the association between metabolic obesity phenotypes with LC risk. (3) Results: During a median follow-up of 9.1 years, 3654 incident LC patients were confirmed among 450,482 individuals. Compared with participants with MHN, those with MUUW had higher rates of incident LC (hazard ratio (HR) = 3.24, 95% confidence interval (CI) = 1.33-7.87, p = 0.009). MHO and MHOW individuals had a 24% and 18% lower risk of developing LC, respectively (MHO: HR = 0.76, 95% CI = 0.61-0.95, p = 0.02; MHO: HR = 0.82, 95% CI = 0.70-0.96, p = 0.02). No genetic association of metabolic obesity phenotypes and LC risk was observed in MR analysis. (4) Conclusions: In this prospective cohort study, individuals with MHOW and MHO phenotypes were at a lower risk and MUUW were at a higher risk of LC. However, MR failed to reveal any evidence that metabolic obesity phenotypes would be associated with a higher risk of LC.

KW - metabolically healthy obesity

KW - lung cancer

KW - metabolic obesity phenotypes

KW - Mendelian randomization

KW - BODY-MASS INDEX

KW - KOREAN MEN

KW - SMOKING

KW - HEALTHY

KW - MORTALITY

KW - FORMER

KW - BLOOD

U2 - 10.3390/nu14163370

DO - 10.3390/nu14163370

M3 - Journal article

C2 - 36014876

VL - 14

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 16

M1 - 3370

ER -