TY - BOOK

T1 - Novel Mechanisms in mTORC1-regulated Muscle Plasticity

AU - Madsen, Agnete Louise Bjerregaard

N1 - CURIS 2018 NEXS 413

PY - 2018

Y1 - 2018

N2 - Balanced activity of the anabolic mTORC1 signalling cascade is central to maintain skeletal muscle mass and health. Hence, it is important to understand its regulation in response to different stimuli.In study 1, we found that mTORC1 targets were regulated differentially, depending on the stimulus such as insulin, amino acids or passive stretch in mouse muscles.In study 2, the catabolic and anabolic signalling network in muscle was assessed by taking a global approach. Our analysis revealed a complex and intertwined network that will provide a valuable resource for future research. From this resource, a muscle-specific protein was identified as a novel target of mTORC1, linking mTORC1 to the regulation of muscle oxidative capacity in response to exercise.Altogether, the results of this PhD thesis provide novel insights into the differentiated regulation of mTORC1 targets upon various stimuli, and they may contribute considerably in the investigation of new therapeutic targets to sustain muscle mass and health.

AB - Balanced activity of the anabolic mTORC1 signalling cascade is central to maintain skeletal muscle mass and health. Hence, it is important to understand its regulation in response to different stimuli.In study 1, we found that mTORC1 targets were regulated differentially, depending on the stimulus such as insulin, amino acids or passive stretch in mouse muscles.In study 2, the catabolic and anabolic signalling network in muscle was assessed by taking a global approach. Our analysis revealed a complex and intertwined network that will provide a valuable resource for future research. From this resource, a muscle-specific protein was identified as a novel target of mTORC1, linking mTORC1 to the regulation of muscle oxidative capacity in response to exercise.Altogether, the results of this PhD thesis provide novel insights into the differentiated regulation of mTORC1 targets upon various stimuli, and they may contribute considerably in the investigation of new therapeutic targets to sustain muscle mass and health.

KW - Faculty of Science

KW - mTORC1

KW - AMPK

KW - ULK1

KW - Autophagy

KW - Skeletal muscle

KW - Muscle plasticity

KW - Molecular mechanisms

KW - Cross-talk between anabolic and catabolic signalling pathways

KW - Physical activity

UR - https://soeg.kb.dk/permalink/45KBDK_KGL/1pioq0f/alma99122845724305763

M3 - Ph.D. thesis

SN - 978-87-7209-211-9

BT - Novel Mechanisms in mTORC1-regulated Muscle Plasticity

PB - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen

CY - Copenhagen

ER -