Obesity, leanness, and mortality: effect modification by physical activity in men and women
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Obesity, leanness, and mortality: effect modification by physical activity in men and women. / Heitmann, Berit; Hills, Andrew P; Frederiksen, Peder; Ward, Leigh C.
In: Obesity, Vol. 17, No. 1, 2009, p. 136-42.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Obesity, leanness, and mortality: effect modification by physical activity in men and women
AU - Heitmann, Berit
AU - Hills, Andrew P
AU - Frederiksen, Peder
AU - Ward, Leigh C
N1 - Keywords: Adult; Body Composition; Body Size; Electric Impedance; Exercise; Female; Humans; Life Style; Male; Middle Aged; Motor Activity; Obesity; Proportional Hazards Models; Questionnaires; Survival Rate; Thinness
PY - 2009
Y1 - 2009
N2 - The 13-year mortality from BMI, body fat (BF), and fat-free mass (FFM) was examined among active and sedentary adults. In total, 2,819 men and women aged 35-65 years in 1987/1988, participating in the Danish MONICA project, were included, and followed for 13.6 years for total mortality. In men, physical activity modified the health hazard of both a high and a low BMI, and the U-shaped association disappeared among the active (hazard ratio (HR) = 0.86, CI: 0.72-1.02). Among active men, FFM was inversely related to mortality (HR = 0.55, 95% CI: 0.40-0.77) whereas a direct positive trend was seen for BF. Among women, physical activity modified association between BMI and mortality, but the U-shaped association remained among the active. Among women, no significant associations were found between either BF or FFM and total mortality. All effects were independent of waist- and hip-circumferences. In conclusion, among men, physical activity may play an important role for the prevention of early mortality beyond its direct effects, by modifying the health hazard of both a high and a low BMI, and by lowering the risk associated with a high BF or a low FFM. Among women physical activity lowers mortality, but an effect-modifying potential of physical activity on associations between BMI or body composition could not be identified.
AB - The 13-year mortality from BMI, body fat (BF), and fat-free mass (FFM) was examined among active and sedentary adults. In total, 2,819 men and women aged 35-65 years in 1987/1988, participating in the Danish MONICA project, were included, and followed for 13.6 years for total mortality. In men, physical activity modified the health hazard of both a high and a low BMI, and the U-shaped association disappeared among the active (hazard ratio (HR) = 0.86, CI: 0.72-1.02). Among active men, FFM was inversely related to mortality (HR = 0.55, 95% CI: 0.40-0.77) whereas a direct positive trend was seen for BF. Among women, physical activity modified association between BMI and mortality, but the U-shaped association remained among the active. Among women, no significant associations were found between either BF or FFM and total mortality. All effects were independent of waist- and hip-circumferences. In conclusion, among men, physical activity may play an important role for the prevention of early mortality beyond its direct effects, by modifying the health hazard of both a high and a low BMI, and by lowering the risk associated with a high BF or a low FFM. Among women physical activity lowers mortality, but an effect-modifying potential of physical activity on associations between BMI or body composition could not be identified.
U2 - 10.1038/oby.2008.479
DO - 10.1038/oby.2008.479
M3 - Journal article
C2 - 18997669
VL - 17
SP - 136
EP - 142
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 1
ER -
ID: 21205388