Occupational exposure to solvents and bladder cancer: A population-based case control study in Nordic countries

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Occupational exposure to solvents and bladder cancer : A population-based case control study in Nordic countries. / Hadkhale, Kishor; Martinsen, Jan Ivar; Weiderpass, Elisabete; Kjaerheim, Kristina; Sparen, Pär; Tryggvadottir, Laufey; Lynge, Elsebeth; Pukkala, Eero.

In: International Journal of Cancer, Vol. 140, No. 8, 15.04.2017, p. 1736–1746.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Hadkhale, K, Martinsen, JI, Weiderpass, E, Kjaerheim, K, Sparen, P, Tryggvadottir, L, Lynge, E & Pukkala, E 2017, 'Occupational exposure to solvents and bladder cancer: A population-based case control study in Nordic countries', International Journal of Cancer, vol. 140, no. 8, pp. 1736–1746. https://doi.org/10.1002/ijc.30593

APA

Hadkhale, K., Martinsen, J. I., Weiderpass, E., Kjaerheim, K., Sparen, P., Tryggvadottir, L., ... Pukkala, E. (2017). Occupational exposure to solvents and bladder cancer: A population-based case control study in Nordic countries. International Journal of Cancer, 140(8), 1736–1746. https://doi.org/10.1002/ijc.30593

Vancouver

Hadkhale K, Martinsen JI, Weiderpass E, Kjaerheim K, Sparen P, Tryggvadottir L et al. Occupational exposure to solvents and bladder cancer: A population-based case control study in Nordic countries. International Journal of Cancer. 2017 Apr 15;140(8):1736–1746. https://doi.org/10.1002/ijc.30593

Author

Hadkhale, Kishor ; Martinsen, Jan Ivar ; Weiderpass, Elisabete ; Kjaerheim, Kristina ; Sparen, Pär ; Tryggvadottir, Laufey ; Lynge, Elsebeth ; Pukkala, Eero. / Occupational exposure to solvents and bladder cancer : A population-based case control study in Nordic countries. In: International Journal of Cancer. 2017 ; Vol. 140, No. 8. pp. 1736–1746.

Bibtex

@article{afa95cfc03514cd1a11c30f38644ab3f,
title = "Occupational exposure to solvents and bladder cancer: A population-based case control study in Nordic countries",
abstract = "The objective of the study was to assess the relationship between exposure to selected solvents and the risk of bladder cancer. This study is based on the Nordic Occupational Cancer (NOCCA) database and comprises 113,343 cases of bladder cancer diagnosed in Finland, Iceland, Norway and Sweden between 1961 and 2005 and 566,715 population controls matched according to country, sex and birth year. Census-based occupational titles of the cases and controls were linked with the job exposure matrix created by the NOCCA project to estimate quantitative cumulative occupational exposures. A conditional logistic regression model was used to estimate hazard ratios (HR) and their 95{\%} confidence intervals (95{\%} CI). Increased risks were observed for trichloroethylene (HR 1.23, 95{\%} 95{\%} CI 1.12-1.40), toluene (HR 1.20, 95{\%} CI 1.00-1.38), benzene (HR 1.16, 95{\%} CI 1.04-1.31), aromatic hydrocarbon solvents (HR 1.10, 95{\%} CI 0.94-1.30) and aliphatic & alicyclic hydrocarbon solvents (HR 1.08, 95{\%} CI 1.00-1.23) at high exposure level versus no exposure. The highest excess for perchloroethylene was observed at medium exposure level (HR 1.12, 95{\%} CI 1.02-1.23). The study provides evidence of an association of occupational exposure to trichloroethylene, perchloroethylene, aromatic hydrocarbon solvents, benzene and toluene and the risk of bladder cancer.",
author = "Kishor Hadkhale and Martinsen, {Jan Ivar} and Elisabete Weiderpass and Kristina Kjaerheim and P{\"a}r Sparen and Laufey Tryggvadottir and Elsebeth Lynge and Eero Pukkala",
note = "{\circledC} 2016 UICC.",
year = "2017",
month = "4",
day = "15",
doi = "10.1002/ijc.30593",
language = "English",
volume = "140",
pages = "1736–1746",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "JohnWiley & Sons, Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Occupational exposure to solvents and bladder cancer

T2 - A population-based case control study in Nordic countries

AU - Hadkhale, Kishor

AU - Martinsen, Jan Ivar

AU - Weiderpass, Elisabete

AU - Kjaerheim, Kristina

AU - Sparen, Pär

AU - Tryggvadottir, Laufey

AU - Lynge, Elsebeth

AU - Pukkala, Eero

N1 - © 2016 UICC.

PY - 2017/4/15

Y1 - 2017/4/15

N2 - The objective of the study was to assess the relationship between exposure to selected solvents and the risk of bladder cancer. This study is based on the Nordic Occupational Cancer (NOCCA) database and comprises 113,343 cases of bladder cancer diagnosed in Finland, Iceland, Norway and Sweden between 1961 and 2005 and 566,715 population controls matched according to country, sex and birth year. Census-based occupational titles of the cases and controls were linked with the job exposure matrix created by the NOCCA project to estimate quantitative cumulative occupational exposures. A conditional logistic regression model was used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI). Increased risks were observed for trichloroethylene (HR 1.23, 95% 95% CI 1.12-1.40), toluene (HR 1.20, 95% CI 1.00-1.38), benzene (HR 1.16, 95% CI 1.04-1.31), aromatic hydrocarbon solvents (HR 1.10, 95% CI 0.94-1.30) and aliphatic & alicyclic hydrocarbon solvents (HR 1.08, 95% CI 1.00-1.23) at high exposure level versus no exposure. The highest excess for perchloroethylene was observed at medium exposure level (HR 1.12, 95% CI 1.02-1.23). The study provides evidence of an association of occupational exposure to trichloroethylene, perchloroethylene, aromatic hydrocarbon solvents, benzene and toluene and the risk of bladder cancer.

AB - The objective of the study was to assess the relationship between exposure to selected solvents and the risk of bladder cancer. This study is based on the Nordic Occupational Cancer (NOCCA) database and comprises 113,343 cases of bladder cancer diagnosed in Finland, Iceland, Norway and Sweden between 1961 and 2005 and 566,715 population controls matched according to country, sex and birth year. Census-based occupational titles of the cases and controls were linked with the job exposure matrix created by the NOCCA project to estimate quantitative cumulative occupational exposures. A conditional logistic regression model was used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI). Increased risks were observed for trichloroethylene (HR 1.23, 95% 95% CI 1.12-1.40), toluene (HR 1.20, 95% CI 1.00-1.38), benzene (HR 1.16, 95% CI 1.04-1.31), aromatic hydrocarbon solvents (HR 1.10, 95% CI 0.94-1.30) and aliphatic & alicyclic hydrocarbon solvents (HR 1.08, 95% CI 1.00-1.23) at high exposure level versus no exposure. The highest excess for perchloroethylene was observed at medium exposure level (HR 1.12, 95% CI 1.02-1.23). The study provides evidence of an association of occupational exposure to trichloroethylene, perchloroethylene, aromatic hydrocarbon solvents, benzene and toluene and the risk of bladder cancer.

U2 - 10.1002/ijc.30593

DO - 10.1002/ijc.30593

M3 - Journal article

C2 - 28032642

VL - 140

SP - 1736

EP - 1746

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 8

ER -

ID: 170769648