Occupational exposure to solvents and bladder cancer: A population-based case control study in Nordic countries
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Occupational exposure to solvents and bladder cancer : A population-based case control study in Nordic countries. / Hadkhale, Kishor; Martinsen, Jan Ivar; Weiderpass, Elisabete; Kjaerheim, Kristina; Sparen, Pär; Tryggvadottir, Laufey; Lynge, Elsebeth; Pukkala, Eero.
In: International Journal of Cancer, Vol. 140, No. 8, 15.04.2017, p. 1736–1746.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Occupational exposure to solvents and bladder cancer
T2 - A population-based case control study in Nordic countries
AU - Hadkhale, Kishor
AU - Martinsen, Jan Ivar
AU - Weiderpass, Elisabete
AU - Kjaerheim, Kristina
AU - Sparen, Pär
AU - Tryggvadottir, Laufey
AU - Lynge, Elsebeth
AU - Pukkala, Eero
N1 - © 2016 UICC.
PY - 2017/4/15
Y1 - 2017/4/15
N2 - The objective of the study was to assess the relationship between exposure to selected solvents and the risk of bladder cancer. This study is based on the Nordic Occupational Cancer (NOCCA) database and comprises 113,343 cases of bladder cancer diagnosed in Finland, Iceland, Norway and Sweden between 1961 and 2005 and 566,715 population controls matched according to country, sex and birth year. Census-based occupational titles of the cases and controls were linked with the job exposure matrix created by the NOCCA project to estimate quantitative cumulative occupational exposures. A conditional logistic regression model was used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI). Increased risks were observed for trichloroethylene (HR 1.23, 95% 95% CI 1.12-1.40), toluene (HR 1.20, 95% CI 1.00-1.38), benzene (HR 1.16, 95% CI 1.04-1.31), aromatic hydrocarbon solvents (HR 1.10, 95% CI 0.94-1.30) and aliphatic & alicyclic hydrocarbon solvents (HR 1.08, 95% CI 1.00-1.23) at high exposure level versus no exposure. The highest excess for perchloroethylene was observed at medium exposure level (HR 1.12, 95% CI 1.02-1.23). The study provides evidence of an association of occupational exposure to trichloroethylene, perchloroethylene, aromatic hydrocarbon solvents, benzene and toluene and the risk of bladder cancer.
AB - The objective of the study was to assess the relationship between exposure to selected solvents and the risk of bladder cancer. This study is based on the Nordic Occupational Cancer (NOCCA) database and comprises 113,343 cases of bladder cancer diagnosed in Finland, Iceland, Norway and Sweden between 1961 and 2005 and 566,715 population controls matched according to country, sex and birth year. Census-based occupational titles of the cases and controls were linked with the job exposure matrix created by the NOCCA project to estimate quantitative cumulative occupational exposures. A conditional logistic regression model was used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI). Increased risks were observed for trichloroethylene (HR 1.23, 95% 95% CI 1.12-1.40), toluene (HR 1.20, 95% CI 1.00-1.38), benzene (HR 1.16, 95% CI 1.04-1.31), aromatic hydrocarbon solvents (HR 1.10, 95% CI 0.94-1.30) and aliphatic & alicyclic hydrocarbon solvents (HR 1.08, 95% CI 1.00-1.23) at high exposure level versus no exposure. The highest excess for perchloroethylene was observed at medium exposure level (HR 1.12, 95% CI 1.02-1.23). The study provides evidence of an association of occupational exposure to trichloroethylene, perchloroethylene, aromatic hydrocarbon solvents, benzene and toluene and the risk of bladder cancer.
U2 - 10.1002/ijc.30593
DO - 10.1002/ijc.30593
M3 - Journal article
C2 - 28032642
VL - 140
SP - 1736
EP - 1746
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 8
ER -
ID: 170769648