Occupational risk variation of nasopharyngeal cancer in the Nordic countries
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Occupational risk variation of nasopharyngeal cancer in the Nordic countries. / Carpén, Timo; Gille, Evelina; Hammarstedt-Nordenvall, Lalle; Hansen, Johnni; Heikkinen, Sanna; Lynge, Elsebeth; Selander, Jenny; Mehlum, Ingrid Sivesind; Torfadottir, Jóhanna Eyrún; Mäkitie, Antti; Pukkala, Eero.
In: BMC Cancer, Vol. 22, No. 1, 1130, 12.2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Occupational risk variation of nasopharyngeal cancer in the Nordic countries
AU - Carpén, Timo
AU - Gille, Evelina
AU - Hammarstedt-Nordenvall, Lalle
AU - Hansen, Johnni
AU - Heikkinen, Sanna
AU - Lynge, Elsebeth
AU - Selander, Jenny
AU - Mehlum, Ingrid Sivesind
AU - Torfadottir, Jóhanna Eyrún
AU - Mäkitie, Antti
AU - Pukkala, Eero
N1 - Publisher Copyright: © 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Background: The aim of this study was to estimate occupational risk variation in the incidence of nasopharyngeal cancer (NPC) in a large population-based cohort of the Nordic Occupational Cancer (NOCCA) study. Methods: This study is based on a cohort of almost 15 million persons from Denmark, Finland, Iceland, Norway and Sweden, with 2898 nasopharyngeal cancer cases diagnosed in 1961–2005. The data on occupations were gathered from population censuses and cancer data from the national cancer registries. Standardized incidence ratios (SIR) with 95% confidence intervals (CI) were estimated using the national NPC incidence rates as the reference. Results: There were 1980 male and 918 female NPC patients. The highest SIRs of NPC were observed among male waiters (SIR 3.69, 95% CI 1.91–6.45) and cooks and stewards (SIR 2.24, 95% CI 1.16–3.91). Among women, launderers had the highest SIR of NPC (2.04, 95% CI 1.02–3.65). Significantly decreased SIRs were found among male farmers (SIR 0.79, 95% CI 0.68–0.92) and male textile workers (SIR 0.49, 95% CI 0.22–0.93). Conclusions: This study suggests that NPC may be associated with several work-related exposure agents such as smoking, kitchen air pollution and solvents. In future, occupational exposure-risk relations should be studied to understand more about causality and to assess effective prevention strategies.
AB - Background: The aim of this study was to estimate occupational risk variation in the incidence of nasopharyngeal cancer (NPC) in a large population-based cohort of the Nordic Occupational Cancer (NOCCA) study. Methods: This study is based on a cohort of almost 15 million persons from Denmark, Finland, Iceland, Norway and Sweden, with 2898 nasopharyngeal cancer cases diagnosed in 1961–2005. The data on occupations were gathered from population censuses and cancer data from the national cancer registries. Standardized incidence ratios (SIR) with 95% confidence intervals (CI) were estimated using the national NPC incidence rates as the reference. Results: There were 1980 male and 918 female NPC patients. The highest SIRs of NPC were observed among male waiters (SIR 3.69, 95% CI 1.91–6.45) and cooks and stewards (SIR 2.24, 95% CI 1.16–3.91). Among women, launderers had the highest SIR of NPC (2.04, 95% CI 1.02–3.65). Significantly decreased SIRs were found among male farmers (SIR 0.79, 95% CI 0.68–0.92) and male textile workers (SIR 0.49, 95% CI 0.22–0.93). Conclusions: This study suggests that NPC may be associated with several work-related exposure agents such as smoking, kitchen air pollution and solvents. In future, occupational exposure-risk relations should be studied to understand more about causality and to assess effective prevention strategies.
KW - Cohort
KW - Incidence
KW - Nasopharyngeal cancer
KW - Occupation
KW - Risk factor
U2 - 10.1186/s12885-022-10209-y
DO - 10.1186/s12885-022-10209-y
M3 - Journal article
C2 - 36333796
AN - SCOPUS:85141201244
VL - 22
JO - B M C Cancer
JF - B M C Cancer
SN - 1471-2407
IS - 1
M1 - 1130
ER -
ID: 343039155