Oral clefts and life style factors--a case-cohort study based on prospective Danish data

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Oral clefts and life style factors--a case-cohort study based on prospective Danish data. / Bille, Camilla; Olsen, Jorn; Vach, Werner; Knudsen, Vibeke Kildegaard; Olsen, Sjurdur Frodi; Rasmussen, Kirsten; Murray, Jeffrey C; Andersen, Anne Marie Nybo; Christensen, Kaare.

In: European Journal of Epidemiology, Vol. 22, No. 3, 2007, p. 173-181.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bille, C, Olsen, J, Vach, W, Knudsen, VK, Olsen, SF, Rasmussen, K, Murray, JC, Andersen, AMN & Christensen, K 2007, 'Oral clefts and life style factors--a case-cohort study based on prospective Danish data', European Journal of Epidemiology, vol. 22, no. 3, pp. 173-181. https://doi.org/10.1007/s10654-006-9099-5

APA

Bille, C., Olsen, J., Vach, W., Knudsen, V. K., Olsen, S. F., Rasmussen, K., ... Christensen, K. (2007). Oral clefts and life style factors--a case-cohort study based on prospective Danish data. European Journal of Epidemiology, 22(3), 173-181. https://doi.org/10.1007/s10654-006-9099-5

Vancouver

Bille C, Olsen J, Vach W, Knudsen VK, Olsen SF, Rasmussen K et al. Oral clefts and life style factors--a case-cohort study based on prospective Danish data. European Journal of Epidemiology. 2007;22(3):173-181. https://doi.org/10.1007/s10654-006-9099-5

Author

Bille, Camilla ; Olsen, Jorn ; Vach, Werner ; Knudsen, Vibeke Kildegaard ; Olsen, Sjurdur Frodi ; Rasmussen, Kirsten ; Murray, Jeffrey C ; Andersen, Anne Marie Nybo ; Christensen, Kaare. / Oral clefts and life style factors--a case-cohort study based on prospective Danish data. In: European Journal of Epidemiology. 2007 ; Vol. 22, No. 3. pp. 173-181.

Bibtex

@article{228e6d209f0011df928f000ea68e967b,
title = "Oral clefts and life style factors--a case-cohort study based on prospective Danish data",
abstract = "This study examines the association between oral clefts and first trimester maternal lifestyle factors based on prospective data from the Danish National Birth Cohort. The cohort includes approximately 100,000 pregnancies. In total 192 mothers gave birth to child with an oral cleft during 1997-2003. Information on risk factors such as smoking, alcohol consumption, tea, coffee, cola, and food supplements was obtained during pregnancy for these and 828 randomly selected controls. We found that first trimester maternal smoking was associated with an increased risk of oral clefts (odds ratio (OR): 1.50; 95{\%} confidence interval (CIs): 1.05, 2.14). Although not statistically significant, we also saw associations with first trimester consumption of alcohol (OR: 1.11; CIs: 0.79, 1.55), tea (OR: 1.31; CIs: 0.93, 1.86), and drinking more than 1 l of cola per week (OR: 1.40; CIs: 0.92, 2.12). Furthermore supplementation with > or =400 mcg folic acid daily during the entire first trimester (OR: 0.75; CIs: 0.46, 1.22) suggested an inverse associated with oral clefts, similar to our results on coffee drinking. No effects were found for smaller doses of folic acid, vitamin A, B6 or B12 in this study. The present study found an association between oral clefts and smoking and, although not conclusive, supports an association of oral cleft with alcohol.",
author = "Camilla Bille and Jorn Olsen and Werner Vach and Knudsen, {Vibeke Kildegaard} and Olsen, {Sjurdur Frodi} and Kirsten Rasmussen and Murray, {Jeffrey C} and Andersen, {Anne Marie Nybo} and Kaare Christensen",
year = "2007",
doi = "10.1007/s10654-006-9099-5",
language = "English",
volume = "22",
pages = "173--181",
journal = "European Journal of Epidemiology",
issn = "0393-2990",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Oral clefts and life style factors--a case-cohort study based on prospective Danish data

AU - Bille, Camilla

AU - Olsen, Jorn

AU - Vach, Werner

AU - Knudsen, Vibeke Kildegaard

AU - Olsen, Sjurdur Frodi

AU - Rasmussen, Kirsten

AU - Murray, Jeffrey C

AU - Andersen, Anne Marie Nybo

AU - Christensen, Kaare

PY - 2007

Y1 - 2007

N2 - This study examines the association between oral clefts and first trimester maternal lifestyle factors based on prospective data from the Danish National Birth Cohort. The cohort includes approximately 100,000 pregnancies. In total 192 mothers gave birth to child with an oral cleft during 1997-2003. Information on risk factors such as smoking, alcohol consumption, tea, coffee, cola, and food supplements was obtained during pregnancy for these and 828 randomly selected controls. We found that first trimester maternal smoking was associated with an increased risk of oral clefts (odds ratio (OR): 1.50; 95% confidence interval (CIs): 1.05, 2.14). Although not statistically significant, we also saw associations with first trimester consumption of alcohol (OR: 1.11; CIs: 0.79, 1.55), tea (OR: 1.31; CIs: 0.93, 1.86), and drinking more than 1 l of cola per week (OR: 1.40; CIs: 0.92, 2.12). Furthermore supplementation with > or =400 mcg folic acid daily during the entire first trimester (OR: 0.75; CIs: 0.46, 1.22) suggested an inverse associated with oral clefts, similar to our results on coffee drinking. No effects were found for smaller doses of folic acid, vitamin A, B6 or B12 in this study. The present study found an association between oral clefts and smoking and, although not conclusive, supports an association of oral cleft with alcohol.

AB - This study examines the association between oral clefts and first trimester maternal lifestyle factors based on prospective data from the Danish National Birth Cohort. The cohort includes approximately 100,000 pregnancies. In total 192 mothers gave birth to child with an oral cleft during 1997-2003. Information on risk factors such as smoking, alcohol consumption, tea, coffee, cola, and food supplements was obtained during pregnancy for these and 828 randomly selected controls. We found that first trimester maternal smoking was associated with an increased risk of oral clefts (odds ratio (OR): 1.50; 95% confidence interval (CIs): 1.05, 2.14). Although not statistically significant, we also saw associations with first trimester consumption of alcohol (OR: 1.11; CIs: 0.79, 1.55), tea (OR: 1.31; CIs: 0.93, 1.86), and drinking more than 1 l of cola per week (OR: 1.40; CIs: 0.92, 2.12). Furthermore supplementation with > or =400 mcg folic acid daily during the entire first trimester (OR: 0.75; CIs: 0.46, 1.22) suggested an inverse associated with oral clefts, similar to our results on coffee drinking. No effects were found for smaller doses of folic acid, vitamin A, B6 or B12 in this study. The present study found an association between oral clefts and smoking and, although not conclusive, supports an association of oral cleft with alcohol.

U2 - 10.1007/s10654-006-9099-5

DO - 10.1007/s10654-006-9099-5

M3 - Journal article

C2 - 17295096

VL - 22

SP - 173

EP - 181

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

IS - 3

ER -

ID: 21161478