Oral clefts and life style factors--a case-cohort study based on prospective Danish data
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Oral clefts and life style factors--a case-cohort study based on prospective Danish data. / Bille, Camilla; Olsen, Jorn; Vach, Werner; Knudsen, Vibeke Kildegaard; Olsen, Sjurdur Frodi; Rasmussen, Kirsten; Murray, Jeffrey C; Andersen, Anne Marie Nybo; Christensen, Kaare.
In: European Journal of Epidemiology, Vol. 22, No. 3, 2007, p. 173-181.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Oral clefts and life style factors--a case-cohort study based on prospective Danish data
AU - Bille, Camilla
AU - Olsen, Jorn
AU - Vach, Werner
AU - Knudsen, Vibeke Kildegaard
AU - Olsen, Sjurdur Frodi
AU - Rasmussen, Kirsten
AU - Murray, Jeffrey C
AU - Andersen, Anne Marie Nybo
AU - Christensen, Kaare
PY - 2007
Y1 - 2007
N2 - This study examines the association between oral clefts and first trimester maternal lifestyle factors based on prospective data from the Danish National Birth Cohort. The cohort includes approximately 100,000 pregnancies. In total 192 mothers gave birth to child with an oral cleft during 1997-2003. Information on risk factors such as smoking, alcohol consumption, tea, coffee, cola, and food supplements was obtained during pregnancy for these and 828 randomly selected controls. We found that first trimester maternal smoking was associated with an increased risk of oral clefts (odds ratio (OR): 1.50; 95% confidence interval (CIs): 1.05, 2.14). Although not statistically significant, we also saw associations with first trimester consumption of alcohol (OR: 1.11; CIs: 0.79, 1.55), tea (OR: 1.31; CIs: 0.93, 1.86), and drinking more than 1 l of cola per week (OR: 1.40; CIs: 0.92, 2.12). Furthermore supplementation with > or =400 mcg folic acid daily during the entire first trimester (OR: 0.75; CIs: 0.46, 1.22) suggested an inverse associated with oral clefts, similar to our results on coffee drinking. No effects were found for smaller doses of folic acid, vitamin A, B6 or B12 in this study. The present study found an association between oral clefts and smoking and, although not conclusive, supports an association of oral cleft with alcohol.
AB - This study examines the association between oral clefts and first trimester maternal lifestyle factors based on prospective data from the Danish National Birth Cohort. The cohort includes approximately 100,000 pregnancies. In total 192 mothers gave birth to child with an oral cleft during 1997-2003. Information on risk factors such as smoking, alcohol consumption, tea, coffee, cola, and food supplements was obtained during pregnancy for these and 828 randomly selected controls. We found that first trimester maternal smoking was associated with an increased risk of oral clefts (odds ratio (OR): 1.50; 95% confidence interval (CIs): 1.05, 2.14). Although not statistically significant, we also saw associations with first trimester consumption of alcohol (OR: 1.11; CIs: 0.79, 1.55), tea (OR: 1.31; CIs: 0.93, 1.86), and drinking more than 1 l of cola per week (OR: 1.40; CIs: 0.92, 2.12). Furthermore supplementation with > or =400 mcg folic acid daily during the entire first trimester (OR: 0.75; CIs: 0.46, 1.22) suggested an inverse associated with oral clefts, similar to our results on coffee drinking. No effects were found for smaller doses of folic acid, vitamin A, B6 or B12 in this study. The present study found an association between oral clefts and smoking and, although not conclusive, supports an association of oral cleft with alcohol.
U2 - 10.1007/s10654-006-9099-5
DO - 10.1007/s10654-006-9099-5
M3 - Journal article
C2 - 17295096
VL - 22
SP - 173
EP - 181
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
SN - 0393-2990
IS - 3
ER -
ID: 21161478