Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes
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Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes. / Clausen, Tine D; Mathiesen, Elisabeth R; Hansen, Torben; Pedersen, Oluf Borbye; Jensen, Dorte M; Lauenborg, Jeannet; Schmidt, Lone; Damm, Peter; Clausen, Tine Dalsgaard; Mathiesen, Elisabeth R; Hansen, Torben; Pedersen, Oluf; Jensen, Dorte; Lauenborg, Jeannet; Schmidt, Lone; Damm, Peter.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 7, 01.07.2009, p. 2464-70.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes
AU - Clausen, Tine D
AU - Mathiesen, Elisabeth R
AU - Hansen, Torben
AU - Pedersen, Oluf Borbye
AU - Jensen, Dorte M
AU - Lauenborg, Jeannet
AU - Schmidt, Lone
AU - Damm, Peter
AU - Clausen, Tine Dalsgaard
AU - Mathiesen, Elisabeth R
AU - Hansen, Torben
AU - Pedersen, Oluf
AU - Jensen, Dorte
AU - Lauenborg, Jeannet
AU - Schmidt, Lone
AU - Damm, Peter
N1 - Export Date: 4 November 2009Source: Scopus
PY - 2009/7/1
Y1 - 2009/7/1
N2 - Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes Context: In animal studies exposure to intrauterine hyperglycemia increases the risk of cardiovascular disease through only partly understood epigenetic mechanisms. Human long-term follow-up studies on the same topic are few. Objective: To study the risk of overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus (GDM) or type 1 diabetes, and additionally to study associations between estimates of maternal hyperglycemia and outcome in the offspring Design: Follow-up study of 1,066 primarily Caucasians aged 18-27 years. Setting: Center for pregnant women with diabetes, Rigshospitalet, Denmark Participants: Offspring of women with diet-treated GDM (n=168) and an un-exposed reference group (n=141). Offspring of women with type 1 diabetes (n=160) and offspring from the background population representing an un-exposed reference group (n=128). Follow-up rate was 56% (597/1,066). Main outcome measures: Overweight: body mass index (BMI) >/= 25kg/m(2). The metabolic syndrome: the International Diabetes Federation 2006 criteria. Results: The risk of overweight was doubled in offspring of women with diet-treated GDM or type 1 diabetes compared with offspring from the background population whereas the risk of the metabolic syndrome was four and 2.5-fold increased, respectively. Offspring risk of the metabolic syndrome increased significantly with increasing maternal fasting blood glucose as well as 2-h blood glucose (during OGTT). Conclusions: Adult offspring of women with diet-treated GDM or type 1 diabetes are risk groups for overweight and the metabolic syndrome. Intrauterine hyperglycemia may in addition to genetics and other factors contribute to the pathogenesis of overweight and the metabolic syndrome.
AB - Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes Context: In animal studies exposure to intrauterine hyperglycemia increases the risk of cardiovascular disease through only partly understood epigenetic mechanisms. Human long-term follow-up studies on the same topic are few. Objective: To study the risk of overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus (GDM) or type 1 diabetes, and additionally to study associations between estimates of maternal hyperglycemia and outcome in the offspring Design: Follow-up study of 1,066 primarily Caucasians aged 18-27 years. Setting: Center for pregnant women with diabetes, Rigshospitalet, Denmark Participants: Offspring of women with diet-treated GDM (n=168) and an un-exposed reference group (n=141). Offspring of women with type 1 diabetes (n=160) and offspring from the background population representing an un-exposed reference group (n=128). Follow-up rate was 56% (597/1,066). Main outcome measures: Overweight: body mass index (BMI) >/= 25kg/m(2). The metabolic syndrome: the International Diabetes Federation 2006 criteria. Results: The risk of overweight was doubled in offspring of women with diet-treated GDM or type 1 diabetes compared with offspring from the background population whereas the risk of the metabolic syndrome was four and 2.5-fold increased, respectively. Offspring risk of the metabolic syndrome increased significantly with increasing maternal fasting blood glucose as well as 2-h blood glucose (during OGTT). Conclusions: Adult offspring of women with diet-treated GDM or type 1 diabetes are risk groups for overweight and the metabolic syndrome. Intrauterine hyperglycemia may in addition to genetics and other factors contribute to the pathogenesis of overweight and the metabolic syndrome.
U2 - 10.1210/jc.2009-0305
DO - 10.1210/jc.2009-0305
M3 - Journal article
C2 - 19417040
VL - 94
SP - 2464
EP - 2470
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 7
ER -
ID: 12324899