α-Peptide/ß-Peptoid Chimeras

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

α-Peptide/ß-Peptoid Chimeras. / Olsen, Christian Adam; Bonke, Gitte ; Vedel, Line; Adsersen, Anne; Witt, Matthias; Franzyk, Henrik; Jaroszewski, Jerzy W.

In: Organic Letters, Vol. 9, No. 8, 2007, p. 1549–1552.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Olsen, CA, Bonke, G, Vedel, L, Adsersen, A, Witt, M, Franzyk, H & Jaroszewski, JW 2007, 'α-Peptide/ß-Peptoid Chimeras', Organic Letters, vol. 9, no. 8, pp. 1549–1552. https://doi.org/10.1021/ol070316c

APA

Olsen, C. A., Bonke, G., Vedel, L., Adsersen, A., Witt, M., Franzyk, H., & Jaroszewski, J. W. (2007). α-Peptide/ß-Peptoid Chimeras. Organic Letters, 9(8), 1549–1552. https://doi.org/10.1021/ol070316c

Vancouver

Olsen CA, Bonke G, Vedel L, Adsersen A, Witt M, Franzyk H et al. α-Peptide/ß-Peptoid Chimeras. Organic Letters. 2007;9(8):1549–1552. https://doi.org/10.1021/ol070316c

Author

Olsen, Christian Adam ; Bonke, Gitte ; Vedel, Line ; Adsersen, Anne ; Witt, Matthias ; Franzyk, Henrik ; Jaroszewski, Jerzy W. / α-Peptide/ß-Peptoid Chimeras. In: Organic Letters. 2007 ; Vol. 9, No. 8. pp. 1549–1552.

Bibtex

@article{8c1965c0ca6311dcbee902004c4f4f50,
title = "α-Peptide/{\ss}-Peptoid Chimeras",
abstract = "We describe the synthesis and characterization of the first generation of oligomers consisting of alternating repeats of a-amino acids and chiral N-alkyl-{\ss}-alanine ({\ss}-peptoid) residues. These chimeras are stable toward proteolysis, non-hemolytic, and possess antibacterial activity comparable to well-known antimicrobial agents. Moreover, the chimeras exhibit length-dependent, concentration-dependent, solvent-dependent, and ion-strength-dependent ellipticity, indicating the presence of a secondary structure in solution. Thus, a-peptide/{\ss}-peptoid oligomers represent a promising novel peptidomimetic backbone construct for biologically active ligands.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Olsen, {Christian Adam} and Gitte Bonke and Line Vedel and Anne Adsersen and Matthias Witt and Henrik Franzyk and Jaroszewski, {Jerzy W.}",
year = "2007",
doi = "10.1021/ol070316c",
language = "English",
volume = "9",
pages = "1549–1552",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "8",

}

RIS

TY - JOUR

T1 - α-Peptide/ß-Peptoid Chimeras

AU - Olsen, Christian Adam

AU - Bonke, Gitte

AU - Vedel, Line

AU - Adsersen, Anne

AU - Witt, Matthias

AU - Franzyk, Henrik

AU - Jaroszewski, Jerzy W.

PY - 2007

Y1 - 2007

N2 - We describe the synthesis and characterization of the first generation of oligomers consisting of alternating repeats of a-amino acids and chiral N-alkyl-ß-alanine (ß-peptoid) residues. These chimeras are stable toward proteolysis, non-hemolytic, and possess antibacterial activity comparable to well-known antimicrobial agents. Moreover, the chimeras exhibit length-dependent, concentration-dependent, solvent-dependent, and ion-strength-dependent ellipticity, indicating the presence of a secondary structure in solution. Thus, a-peptide/ß-peptoid oligomers represent a promising novel peptidomimetic backbone construct for biologically active ligands.

AB - We describe the synthesis and characterization of the first generation of oligomers consisting of alternating repeats of a-amino acids and chiral N-alkyl-ß-alanine (ß-peptoid) residues. These chimeras are stable toward proteolysis, non-hemolytic, and possess antibacterial activity comparable to well-known antimicrobial agents. Moreover, the chimeras exhibit length-dependent, concentration-dependent, solvent-dependent, and ion-strength-dependent ellipticity, indicating the presence of a secondary structure in solution. Thus, a-peptide/ß-peptoid oligomers represent a promising novel peptidomimetic backbone construct for biologically active ligands.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1021/ol070316c

DO - 10.1021/ol070316c

M3 - Journal article

VL - 9

SP - 1549

EP - 1552

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 8

ER -

ID: 2432955