Placental transfer of pesticides studied in human placental perfusion
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Placental transfer of pesticides studied in human placental perfusion. / Mathiesen, Line; Mørck, Thit Aarøe; Poulsen, Marie Sønnegaard; Nielsen, Jeanette Kolstrup Søgaard; Mose, Tina; Long, Manhai; Bonefeld-Jørgensen, Eva; Bossi, Rossana; Knudsen, Lisbeth E.
In: Basic & Clinical Pharmacology & Toxicology, Vol. 127, No. 6, 2020, p. 505-515.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Placental transfer of pesticides studied in human placental perfusion
AU - Mathiesen, Line
AU - Mørck, Thit Aarøe
AU - Poulsen, Marie Sønnegaard
AU - Nielsen, Jeanette Kolstrup Søgaard
AU - Mose, Tina
AU - Long, Manhai
AU - Bonefeld-Jørgensen, Eva
AU - Bossi, Rossana
AU - Knudsen, Lisbeth E.
PY - 2020
Y1 - 2020
N2 - To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the selection criteria: use in Denmark, significant treated areas and knowledge on hormone-disrupting effects. Propiconazole and bitertanol showed rapid transfer and adsorbance to the system in both placental perfusion and BeWo cell system, whereas cypermethrin had a slower transport across the placental cell layers in the two models. There was no difference between data of the single pesticides and their mixture in either placental perfusion or BeWo cell transfer model. Both the placental perfusion model and the BeWo cell model metabolized the pesticides and released metabolites into both foetal and maternal circulation. Using human exposure models, this study shows the potential exposure of the human foetus to pesticides cypermethrin, propiconazole and bitertanol and their metabolites.
AB - To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the selection criteria: use in Denmark, significant treated areas and knowledge on hormone-disrupting effects. Propiconazole and bitertanol showed rapid transfer and adsorbance to the system in both placental perfusion and BeWo cell system, whereas cypermethrin had a slower transport across the placental cell layers in the two models. There was no difference between data of the single pesticides and their mixture in either placental perfusion or BeWo cell transfer model. Both the placental perfusion model and the BeWo cell model metabolized the pesticides and released metabolites into both foetal and maternal circulation. Using human exposure models, this study shows the potential exposure of the human foetus to pesticides cypermethrin, propiconazole and bitertanol and their metabolites.
KW - BeWo cell model
KW - bitertanol
KW - cypermethrin
KW - foetal exposure
KW - pesticides
KW - placental transport
KW - propiconazole
U2 - 10.1111/bcpt.13456
DO - 10.1111/bcpt.13456
M3 - Journal article
C2 - 32558230
AN - SCOPUS:85087558502
VL - 127
SP - 505
EP - 515
JO - Basic and Clinical Pharmacology and Toxicology
JF - Basic and Clinical Pharmacology and Toxicology
SN - 1742-7835
IS - 6
ER -
ID: 244915495