Possible Modifiers of the Association Between Change in Weight Status From Child Through Adult Ages and Later Risk of Type 2 Diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Possible Modifiers of the Association Between Change in Weight Status From Child Through Adult Ages and Later Risk of Type 2 Diabetes. / Bjerregaard, Lise G; Wasenius, Niko; Nedelec, Rozenn; Gjærde, Line K; Ängquist, Lars; Herzig, Karl-Heinz; Jensen, Gorm B.; Mortensen, Erik L; Osler, Merete; Overvad, Kim; Skaaby, Tea; Tjønneland, Anne; Sørensen, Thorkild I A; Järvelin, Marjo-Riitta; Eriksson, Johan G; Sebert, Sylvain; Baker, Jennifer L.

In: Diabetes Care. Supplement, Vol. 43, No. 5, 2020, p. 1000-1007.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bjerregaard, LG, Wasenius, N, Nedelec, R, Gjærde, LK, Ängquist, L, Herzig, K-H, Jensen, GB, Mortensen, EL, Osler, M, Overvad, K, Skaaby, T, Tjønneland, A, Sørensen, TIA, Järvelin, M-R, Eriksson, JG, Sebert, S & Baker, JL 2020, 'Possible Modifiers of the Association Between Change in Weight Status From Child Through Adult Ages and Later Risk of Type 2 Diabetes', Diabetes Care. Supplement, vol. 43, no. 5, pp. 1000-1007. https://doi.org/10.2337/dc19-1726

APA

Bjerregaard, L. G., Wasenius, N., Nedelec, R., Gjærde, L. K., Ängquist, L., Herzig, K-H., ... Baker, J. L. (2020). Possible Modifiers of the Association Between Change in Weight Status From Child Through Adult Ages and Later Risk of Type 2 Diabetes. Diabetes Care. Supplement, 43(5), 1000-1007. https://doi.org/10.2337/dc19-1726

Vancouver

Bjerregaard LG, Wasenius N, Nedelec R, Gjærde LK, Ängquist L, Herzig K-H et al. Possible Modifiers of the Association Between Change in Weight Status From Child Through Adult Ages and Later Risk of Type 2 Diabetes. Diabetes Care. Supplement. 2020;43(5):1000-1007. https://doi.org/10.2337/dc19-1726

Author

Bjerregaard, Lise G ; Wasenius, Niko ; Nedelec, Rozenn ; Gjærde, Line K ; Ängquist, Lars ; Herzig, Karl-Heinz ; Jensen, Gorm B. ; Mortensen, Erik L ; Osler, Merete ; Overvad, Kim ; Skaaby, Tea ; Tjønneland, Anne ; Sørensen, Thorkild I A ; Järvelin, Marjo-Riitta ; Eriksson, Johan G ; Sebert, Sylvain ; Baker, Jennifer L. / Possible Modifiers of the Association Between Change in Weight Status From Child Through Adult Ages and Later Risk of Type 2 Diabetes. In: Diabetes Care. Supplement. 2020 ; Vol. 43, No. 5. pp. 1000-1007.

Bibtex

@article{e9b1bb49b67647d38d9adedcbc771a3d,
title = "Possible Modifiers of the Association Between Change in Weight Status From Child Through Adult Ages and Later Risk of Type 2 Diabetes",
abstract = "OBJECTIVE: We investigated the association between changes in weight status from childhood through adulthood and subsequent type 2 diabetes risks and whether educational attainment, smoking, and leisure time physical activity (LTPA) modify this association.RESEARCH DESIGN AND METHODS: Using data from 10 Danish and Finnish cohorts including 25,283 individuals, childhood BMI at 7 and 12 years was categorized as normal or high using age- and sex-specific cutoffs (<85th or ≥85th percentile). Adult BMI (20-71 years) was categorized as nonobese or obese (<30.0 or ≥30.0 kg/m2, respectively). Associations between BMI patterns and type 2 diabetes (989 women and 1,370 men) were analyzed using Cox proportional hazard regressions and meta-analysis techniques.RESULTS: Compared with individuals with a normal BMI at 7 years and without adult obesity, those with a high BMI at 7 years and adult obesity had higher type 2 diabetes risks (hazard ratio [HR]girls: 5.04 [95{\%} CI 3.92-6.48]; HRboys: 3.78 [95{\%} CI 2.68-5.33]). Individuals with a high BMI at 7 years but without adult obesity did not have a higher risk (HRgirls: 0.74 [95{\%} CI 0.52-1.06]; HRboys: 0.93 [95{\%} CI 0.65-1.33]). Education, smoking, and LTPA were associated with diabetes risks, but did not modify or confound the associations with BMI changes. Results for 12 years of age were similar.CONCLUSIONS: A high BMI in childhood was associated with higher type 2 diabetes risks only if individuals also had obesity in adulthood. These associations were not influenced by educational and lifestyle factors, indicating that BMI is similarly related to the risk across all levels of these factors.",
author = "Bjerregaard, {Lise G} and Niko Wasenius and Rozenn Nedelec and Gj{\ae}rde, {Line K} and Lars {\"A}ngquist and Karl-Heinz Herzig and Jensen, {Gorm B.} and Mortensen, {Erik L} and Merete Osler and Kim Overvad and Tea Skaaby and Anne Tj{\o}nneland and S{\o}rensen, {Thorkild I A} and Marjo-Riitta J{\"a}rvelin and Eriksson, {Johan G} and Sylvain Sebert and Baker, {Jennifer L}",
note = "{\circledC} 2020 by the American Diabetes Association.",
year = "2020",
doi = "10.2337/dc19-1726",
language = "English",
volume = "43",
pages = "1000--1007",
journal = "Diabetes Care. Supplement",
issn = "1064-9131",
publisher = "American Diabetes Association",
number = "5",

}

RIS

TY - JOUR

T1 - Possible Modifiers of the Association Between Change in Weight Status From Child Through Adult Ages and Later Risk of Type 2 Diabetes

AU - Bjerregaard, Lise G

AU - Wasenius, Niko

AU - Nedelec, Rozenn

AU - Gjærde, Line K

AU - Ängquist, Lars

AU - Herzig, Karl-Heinz

AU - Jensen, Gorm B.

AU - Mortensen, Erik L

AU - Osler, Merete

AU - Overvad, Kim

AU - Skaaby, Tea

AU - Tjønneland, Anne

AU - Sørensen, Thorkild I A

AU - Järvelin, Marjo-Riitta

AU - Eriksson, Johan G

AU - Sebert, Sylvain

AU - Baker, Jennifer L

N1 - © 2020 by the American Diabetes Association.

PY - 2020

Y1 - 2020

N2 - OBJECTIVE: We investigated the association between changes in weight status from childhood through adulthood and subsequent type 2 diabetes risks and whether educational attainment, smoking, and leisure time physical activity (LTPA) modify this association.RESEARCH DESIGN AND METHODS: Using data from 10 Danish and Finnish cohorts including 25,283 individuals, childhood BMI at 7 and 12 years was categorized as normal or high using age- and sex-specific cutoffs (<85th or ≥85th percentile). Adult BMI (20-71 years) was categorized as nonobese or obese (<30.0 or ≥30.0 kg/m2, respectively). Associations between BMI patterns and type 2 diabetes (989 women and 1,370 men) were analyzed using Cox proportional hazard regressions and meta-analysis techniques.RESULTS: Compared with individuals with a normal BMI at 7 years and without adult obesity, those with a high BMI at 7 years and adult obesity had higher type 2 diabetes risks (hazard ratio [HR]girls: 5.04 [95% CI 3.92-6.48]; HRboys: 3.78 [95% CI 2.68-5.33]). Individuals with a high BMI at 7 years but without adult obesity did not have a higher risk (HRgirls: 0.74 [95% CI 0.52-1.06]; HRboys: 0.93 [95% CI 0.65-1.33]). Education, smoking, and LTPA were associated with diabetes risks, but did not modify or confound the associations with BMI changes. Results for 12 years of age were similar.CONCLUSIONS: A high BMI in childhood was associated with higher type 2 diabetes risks only if individuals also had obesity in adulthood. These associations were not influenced by educational and lifestyle factors, indicating that BMI is similarly related to the risk across all levels of these factors.

AB - OBJECTIVE: We investigated the association between changes in weight status from childhood through adulthood and subsequent type 2 diabetes risks and whether educational attainment, smoking, and leisure time physical activity (LTPA) modify this association.RESEARCH DESIGN AND METHODS: Using data from 10 Danish and Finnish cohorts including 25,283 individuals, childhood BMI at 7 and 12 years was categorized as normal or high using age- and sex-specific cutoffs (<85th or ≥85th percentile). Adult BMI (20-71 years) was categorized as nonobese or obese (<30.0 or ≥30.0 kg/m2, respectively). Associations between BMI patterns and type 2 diabetes (989 women and 1,370 men) were analyzed using Cox proportional hazard regressions and meta-analysis techniques.RESULTS: Compared with individuals with a normal BMI at 7 years and without adult obesity, those with a high BMI at 7 years and adult obesity had higher type 2 diabetes risks (hazard ratio [HR]girls: 5.04 [95% CI 3.92-6.48]; HRboys: 3.78 [95% CI 2.68-5.33]). Individuals with a high BMI at 7 years but without adult obesity did not have a higher risk (HRgirls: 0.74 [95% CI 0.52-1.06]; HRboys: 0.93 [95% CI 0.65-1.33]). Education, smoking, and LTPA were associated with diabetes risks, but did not modify or confound the associations with BMI changes. Results for 12 years of age were similar.CONCLUSIONS: A high BMI in childhood was associated with higher type 2 diabetes risks only if individuals also had obesity in adulthood. These associations were not influenced by educational and lifestyle factors, indicating that BMI is similarly related to the risk across all levels of these factors.

U2 - 10.2337/dc19-1726

DO - 10.2337/dc19-1726

M3 - Journal article

C2 - 32139388

VL - 43

SP - 1000

EP - 1007

JO - Diabetes Care. Supplement

JF - Diabetes Care. Supplement

SN - 1064-9131

IS - 5

ER -

ID: 237411036