Probable long-term prevalence for a predominant Mycobacterium tuberculosis clone of a Beijing genotype in Colon, Panama

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Probable long-term prevalence for a predominant Mycobacterium tuberculosis clone of a Beijing genotype in Colon, Panama. / Acosta, Fermin; Norman, Anders; Sambrano, Dilcia; Batista, Victoria; Mokrousov, Igor; Shitikov, Egor; Jurado, Julio; Mayrena, Maritza; Luque, Odemaris; Garay, Maybis; Solis, Laura; Munoz, Patricia; Folkvardsen, Dorte B.; Lillebæk, Troels; Perez-Lago, Laura; Goodridge, Amador; Garcia de Viedma, Dario.

In: Transboundary and Emerging Diseases, Vol. 68, No. 4, 2021, p. 2229-2238.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Acosta, F, Norman, A, Sambrano, D, Batista, V, Mokrousov, I, Shitikov, E, Jurado, J, Mayrena, M, Luque, O, Garay, M, Solis, L, Munoz, P, Folkvardsen, DB, Lillebæk, T, Perez-Lago, L, Goodridge, A & Garcia de Viedma, D 2021, 'Probable long-term prevalence for a predominant Mycobacterium tuberculosis clone of a Beijing genotype in Colon, Panama', Transboundary and Emerging Diseases, vol. 68, no. 4, pp. 2229-2238. https://doi.org/10.1111/tbed.13875

APA

Acosta, F., Norman, A., Sambrano, D., Batista, V., Mokrousov, I., Shitikov, E., Jurado, J., Mayrena, M., Luque, O., Garay, M., Solis, L., Munoz, P., Folkvardsen, D. B., Lillebæk, T., Perez-Lago, L., Goodridge, A., & Garcia de Viedma, D. (2021). Probable long-term prevalence for a predominant Mycobacterium tuberculosis clone of a Beijing genotype in Colon, Panama. Transboundary and Emerging Diseases, 68(4), 2229-2238. https://doi.org/10.1111/tbed.13875

Vancouver

Acosta F, Norman A, Sambrano D, Batista V, Mokrousov I, Shitikov E et al. Probable long-term prevalence for a predominant Mycobacterium tuberculosis clone of a Beijing genotype in Colon, Panama. Transboundary and Emerging Diseases. 2021;68(4):2229-2238. https://doi.org/10.1111/tbed.13875

Author

Acosta, Fermin ; Norman, Anders ; Sambrano, Dilcia ; Batista, Victoria ; Mokrousov, Igor ; Shitikov, Egor ; Jurado, Julio ; Mayrena, Maritza ; Luque, Odemaris ; Garay, Maybis ; Solis, Laura ; Munoz, Patricia ; Folkvardsen, Dorte B. ; Lillebæk, Troels ; Perez-Lago, Laura ; Goodridge, Amador ; Garcia de Viedma, Dario. / Probable long-term prevalence for a predominant Mycobacterium tuberculosis clone of a Beijing genotype in Colon, Panama. In: Transboundary and Emerging Diseases. 2021 ; Vol. 68, No. 4. pp. 2229-2238.

Bibtex

@article{6e40585fa1654f27aa7401ced587d07c,
title = "Probable long-term prevalence for a predominant Mycobacterium tuberculosis clone of a Beijing genotype in Colon, Panama",
abstract = "Beijing genotype Mycobacterium tuberculosis strains associate with increased virulence, resistance and/or higher transmission rates. This study describes a specific Beijing strain predominantly identified in the Panamanian province of Colon with one of the highest incidences of tuberculosis in the country. Retrospective mycobacterial interspersed repetitive unit/variable number of tandem repeats analysis of 42 isolates collected between January and August 2018 allowed to identify a cluster (Beijing A) with 17 (40.5%) Beijing isolates. Subsequent prospective strain-specific PCR-based surveillance from September 2019 to March 2020 confirmed the predominance of the Beijing A strain (44.1%) in this province. Whole-genome sequencing revealed higher-than-expected diversity within the cluster, suggesting long-term prevalence of this strain and low number of cases caused by recent transmission. The Beijing A strain belongs to the Asian African 3 (Bmyc13, L2.2.5) branch of the modern Beijing sublineage, with their closest isolates corresponding to cases from Vietnam, probably introduced in Panama between 2000 and 2012.",
keywords = "Beijing lineage, Mycobacterium tuberculosis, Panama, predominant, strain&#8208, specific&#8208, PCR, DRUG-RESISTANCE, TRANSMISSION, STRAINS, EPIDEMIOLOGY, COEXPANSION, EMERGENCE, COUNTRIES, OUTBREAKS, PROPOSAL, ORIGIN",
author = "Fermin Acosta and Anders Norman and Dilcia Sambrano and Victoria Batista and Igor Mokrousov and Egor Shitikov and Julio Jurado and Maritza Mayrena and Odemaris Luque and Maybis Garay and Laura Solis and Patricia Munoz and Folkvardsen, {Dorte B.} and Troels Lilleb{\ae}k and Laura Perez-Lago and Amador Goodridge and {Garcia de Viedma}, Dario",
year = "2021",
doi = "10.1111/tbed.13875",
language = "English",
volume = "68",
pages = "2229--2238",
journal = "Transboundary and Emerging Diseases",
issn = "1865-1674",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Probable long-term prevalence for a predominant Mycobacterium tuberculosis clone of a Beijing genotype in Colon, Panama

AU - Acosta, Fermin

AU - Norman, Anders

AU - Sambrano, Dilcia

AU - Batista, Victoria

AU - Mokrousov, Igor

AU - Shitikov, Egor

AU - Jurado, Julio

AU - Mayrena, Maritza

AU - Luque, Odemaris

AU - Garay, Maybis

AU - Solis, Laura

AU - Munoz, Patricia

AU - Folkvardsen, Dorte B.

AU - Lillebæk, Troels

AU - Perez-Lago, Laura

AU - Goodridge, Amador

AU - Garcia de Viedma, Dario

PY - 2021

Y1 - 2021

N2 - Beijing genotype Mycobacterium tuberculosis strains associate with increased virulence, resistance and/or higher transmission rates. This study describes a specific Beijing strain predominantly identified in the Panamanian province of Colon with one of the highest incidences of tuberculosis in the country. Retrospective mycobacterial interspersed repetitive unit/variable number of tandem repeats analysis of 42 isolates collected between January and August 2018 allowed to identify a cluster (Beijing A) with 17 (40.5%) Beijing isolates. Subsequent prospective strain-specific PCR-based surveillance from September 2019 to March 2020 confirmed the predominance of the Beijing A strain (44.1%) in this province. Whole-genome sequencing revealed higher-than-expected diversity within the cluster, suggesting long-term prevalence of this strain and low number of cases caused by recent transmission. The Beijing A strain belongs to the Asian African 3 (Bmyc13, L2.2.5) branch of the modern Beijing sublineage, with their closest isolates corresponding to cases from Vietnam, probably introduced in Panama between 2000 and 2012.

AB - Beijing genotype Mycobacterium tuberculosis strains associate with increased virulence, resistance and/or higher transmission rates. This study describes a specific Beijing strain predominantly identified in the Panamanian province of Colon with one of the highest incidences of tuberculosis in the country. Retrospective mycobacterial interspersed repetitive unit/variable number of tandem repeats analysis of 42 isolates collected between January and August 2018 allowed to identify a cluster (Beijing A) with 17 (40.5%) Beijing isolates. Subsequent prospective strain-specific PCR-based surveillance from September 2019 to March 2020 confirmed the predominance of the Beijing A strain (44.1%) in this province. Whole-genome sequencing revealed higher-than-expected diversity within the cluster, suggesting long-term prevalence of this strain and low number of cases caused by recent transmission. The Beijing A strain belongs to the Asian African 3 (Bmyc13, L2.2.5) branch of the modern Beijing sublineage, with their closest isolates corresponding to cases from Vietnam, probably introduced in Panama between 2000 and 2012.

KW - Beijing lineage

KW - Mycobacterium tuberculosis

KW - Panama

KW - predominant

KW - strain&#8208

KW - specific&#8208

KW - PCR

KW - DRUG-RESISTANCE

KW - TRANSMISSION

KW - STRAINS

KW - EPIDEMIOLOGY

KW - COEXPANSION

KW - EMERGENCE

KW - COUNTRIES

KW - OUTBREAKS

KW - PROPOSAL

KW - ORIGIN

U2 - 10.1111/tbed.13875

DO - 10.1111/tbed.13875

M3 - Journal article

C2 - 33048439

VL - 68

SP - 2229

EP - 2238

JO - Transboundary and Emerging Diseases

JF - Transboundary and Emerging Diseases

SN - 1865-1674

IS - 4

ER -

ID: 251685505