Pseudo-observations for competing risks with covariate dependent censoring
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Pseudo-observations for competing risks with covariate dependent censoring. / Binder, Nadine; Gerds, Thomas A; Andersen, Per Kragh.
In: Lifetime Data Analysis, Vol. 20, No. 2, 04.2014, p. 303-15.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pseudo-observations for competing risks with covariate dependent censoring
AU - Binder, Nadine
AU - Gerds, Thomas A
AU - Andersen, Per Kragh
PY - 2014/4
Y1 - 2014/4
N2 - Regression analysis for competing risks data can be based on generalized estimating equations. For the case with right censored data, pseudo-values were proposed to solve the estimating equations. In this article we investigate robustness of the pseudo-values against violation of the assumption that the probability of not being lost to follow-up (un-censored) is independent of the covariates. Modified pseudo-values are proposed which rely on a correctly specified regression model for the censoring times. Bias and efficiency of these methods are compared in a simulation study. Further illustration of the differences is obtained in an application to bone marrow transplantation data and a corresponding sensitivity analysis.
AB - Regression analysis for competing risks data can be based on generalized estimating equations. For the case with right censored data, pseudo-values were proposed to solve the estimating equations. In this article we investigate robustness of the pseudo-values against violation of the assumption that the probability of not being lost to follow-up (un-censored) is independent of the covariates. Modified pseudo-values are proposed which rely on a correctly specified regression model for the censoring times. Bias and efficiency of these methods are compared in a simulation study. Further illustration of the differences is obtained in an application to bone marrow transplantation data and a corresponding sensitivity analysis.
U2 - 10.1007/s10985-013-9247-7
DO - 10.1007/s10985-013-9247-7
M3 - Journal article
C2 - 23430270
VL - 20
SP - 303
EP - 315
JO - Lifetime Data Analysis
JF - Lifetime Data Analysis
SN - 1380-7870
IS - 2
ER -
ID: 134781594