TY - JOUR

T1 - Psychosocial job strain and risk of congenital malformations in offspring

T2 - a Danish National cohort study

AU - Larsen, Allan Boye Vagn

AU - Hannerz, H

AU - Thulstrup, A M

AU - Bonde, J P

AU - Obel, C

AU - Hougaard, K S

N1 - © 2014 Royal College of Obstetricians and Gynaecologists.

PY - 2014/6

Y1 - 2014/6

N2 - OBJECTIVE: To investigate if maternal exposure to psychosocial job strain at work (high demands and low control) measured by questionnaire early in pregnancy (median week 15) is associated with malformations in the offspring.DESIGN: Population-based cohort study.SETTING: The Danish National Birth Cohort.POPULATION: A cohort of 60,386 singleton children with full information on mother's occupational status, exposure to psychosocial job strain and all covariates during pregnancy.METHODS: Logistic regression analysis was used to calculate the odds of congenital malformations as a function of job strain with adjustment for maternal age, body mass index, parity, smoking, alcohol use, manual versus nonmanual work, maternal serious disease and gestational age at interview.MAIN OUTCOME MEASURES: Circulatory malformation, musculoskeletal malformation or any malformation.RESULTS: Logistic regression analyses, both crude and adjusted, indicated no associations between working under high strain and giving birth to a child with circulatory malformation (adjusted odds ratio [OR] 1.04, 95% confidence interval [95% CI] 0.75-1.44), musculoskeletal malformation (aOR 0.88, 95% CI 0.71-1.10) or any malformation (aOR 0.99, 95% CI 0.85-1.15). Supplementary analyses including restriction to first-borns and a stratified analysis with respect to manual and nonmanual work did not change the results.CONCLUSIONS: Association between exposure to high job strain during pregnancy and elevated risk of circulatory, muscle and any malformations is not supported by this study.

AB - OBJECTIVE: To investigate if maternal exposure to psychosocial job strain at work (high demands and low control) measured by questionnaire early in pregnancy (median week 15) is associated with malformations in the offspring.DESIGN: Population-based cohort study.SETTING: The Danish National Birth Cohort.POPULATION: A cohort of 60,386 singleton children with full information on mother's occupational status, exposure to psychosocial job strain and all covariates during pregnancy.METHODS: Logistic regression analysis was used to calculate the odds of congenital malformations as a function of job strain with adjustment for maternal age, body mass index, parity, smoking, alcohol use, manual versus nonmanual work, maternal serious disease and gestational age at interview.MAIN OUTCOME MEASURES: Circulatory malformation, musculoskeletal malformation or any malformation.RESULTS: Logistic regression analyses, both crude and adjusted, indicated no associations between working under high strain and giving birth to a child with circulatory malformation (adjusted odds ratio [OR] 1.04, 95% confidence interval [95% CI] 0.75-1.44), musculoskeletal malformation (aOR 0.88, 95% CI 0.71-1.10) or any malformation (aOR 0.99, 95% CI 0.85-1.15). Supplementary analyses including restriction to first-borns and a stratified analysis with respect to manual and nonmanual work did not change the results.CONCLUSIONS: Association between exposure to high job strain during pregnancy and elevated risk of circulatory, muscle and any malformations is not supported by this study.

KW - Adult

KW - Cohort Studies

KW - Congenital Abnormalities

KW - Denmark

KW - Female

KW - Humans

KW - Infant, Newborn

KW - Occupational Diseases

KW - Pregnancy

KW - Pregnancy Complications

KW - Risk Factors

KW - Stress, Psychological

KW - Young Adult

U2 - 10.1111/1471-0528.12612

DO - 10.1111/1471-0528.12612

M3 - Journal article

C2 - 24593253

VL - 121

SP - 830-8; discussion 839

JO - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

SN - 0140-7686

IS - 7

ER -