P-wave indices as predictors of atrial fibrillation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

P-wave indices as predictors of atrial fibrillation. / Rasmussen, Maria Uggen; Kumarathurai, Preman; Fabricius-Bjerre, Andreas; Larsen, Bjorn Stroier; Dominguez, Helena; Davidsen, Ulla; Gerds, Thomas Alexander; Kanters, Jørgen K.; Sajadieh, Ahmad.

In: Annals of Noninvasive Electrocardiology, Vol. 25, No. 5, e12751, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rasmussen, MU, Kumarathurai, P, Fabricius-Bjerre, A, Larsen, BS, Dominguez, H, Davidsen, U, Gerds, TA, Kanters, JK & Sajadieh, A 2020, 'P-wave indices as predictors of atrial fibrillation', Annals of Noninvasive Electrocardiology, vol. 25, no. 5, e12751. https://doi.org/10.1111/anec.12751

APA

Rasmussen, M. U., Kumarathurai, P., Fabricius-Bjerre, A., Larsen, B. S., Dominguez, H., Davidsen, U., Gerds, T. A., Kanters, J. K., & Sajadieh, A. (2020). P-wave indices as predictors of atrial fibrillation. Annals of Noninvasive Electrocardiology, 25(5), [e12751]. https://doi.org/10.1111/anec.12751

Vancouver

Rasmussen MU, Kumarathurai P, Fabricius-Bjerre A, Larsen BS, Dominguez H, Davidsen U et al. P-wave indices as predictors of atrial fibrillation. Annals of Noninvasive Electrocardiology. 2020;25(5). e12751. https://doi.org/10.1111/anec.12751

Author

Rasmussen, Maria Uggen ; Kumarathurai, Preman ; Fabricius-Bjerre, Andreas ; Larsen, Bjorn Stroier ; Dominguez, Helena ; Davidsen, Ulla ; Gerds, Thomas Alexander ; Kanters, Jørgen K. ; Sajadieh, Ahmad. / P-wave indices as predictors of atrial fibrillation. In: Annals of Noninvasive Electrocardiology. 2020 ; Vol. 25, No. 5.

Bibtex

@article{90849377aa1e4bb795a604190c854d98,
title = "P-wave indices as predictors of atrial fibrillation",
abstract = "Background P-wave duration (P-DURATION) and P-wave area (P-AREA) have been linked to risk of atrial fibrillation (AF), but they do not improve the efficacy of Framingham AF risk score. We suggest the incorporation of both variables in one index, the P-wave area/P-wave duration (P-AREA(/)DURATION) index, which may be considered an expression of the average amplitude of the P wave that reflects aspects of P-wave morphology. Objective To assess the prognostic value of P-wave area/P-wave duration index (P(AREA/DURATION)index) in lead II together with other P-wave indices (PWIs) in incidence of AF in the Copenhagen Holter Study. Methods The study included 632 men and women, between 55 and 75 years with no apparent heart disease or AF. Baseline standard 12-lead Electrocardiography (ECGs) were analyzed manually. Results The median follow-up time was 14.7 (14.5;14.9) years. A total of 68 cases of AF and 233 cases of death were recorded. The restricted cubic spline method showed a U-shaped association between P(AREA/DURATION)and rate of AF. The lowest quintile of P(AREA/DURATION)index in lead II was associated with increased rate of AF, HR 2.80 (1.64-4.79). The addition of the new index to the Framingham model for AF improved the model in this population. The P(AREA)in lead II in its lowest quintile was also associated with increased rate of AF, HR 2.16 (1.25-3.75), but did not improve the Framingham model. P(DURATION)and P-wave terminal force (PTF) were not significantly associated with AF. Conclusion A flat P wave as expressed by a small P(AREA/DURATION)index in lead II is associated with increased rate of incident AF beyond known AF risk factors.",
keywords = "atrial fibrillation, electrocardiography, P wave, P-wave indices, ECG LEAD PLACEMENT, RISK, ACCURACY, DURATION, POSITION, FIBROSIS, STROKE, ECTOPY, RHYTHM",
author = "Rasmussen, {Maria Uggen} and Preman Kumarathurai and Andreas Fabricius-Bjerre and Larsen, {Bjorn Stroier} and Helena Dominguez and Ulla Davidsen and Gerds, {Thomas Alexander} and Kanters, {J{\o}rgen K.} and Ahmad Sajadieh",
year = "2020",
doi = "10.1111/anec.12751",
language = "English",
volume = "25",
journal = "Annals of Noninvasive Electrocardiology",
issn = "1542-474X",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - P-wave indices as predictors of atrial fibrillation

AU - Rasmussen, Maria Uggen

AU - Kumarathurai, Preman

AU - Fabricius-Bjerre, Andreas

AU - Larsen, Bjorn Stroier

AU - Dominguez, Helena

AU - Davidsen, Ulla

AU - Gerds, Thomas Alexander

AU - Kanters, Jørgen K.

AU - Sajadieh, Ahmad

PY - 2020

Y1 - 2020

N2 - Background P-wave duration (P-DURATION) and P-wave area (P-AREA) have been linked to risk of atrial fibrillation (AF), but they do not improve the efficacy of Framingham AF risk score. We suggest the incorporation of both variables in one index, the P-wave area/P-wave duration (P-AREA(/)DURATION) index, which may be considered an expression of the average amplitude of the P wave that reflects aspects of P-wave morphology. Objective To assess the prognostic value of P-wave area/P-wave duration index (P(AREA/DURATION)index) in lead II together with other P-wave indices (PWIs) in incidence of AF in the Copenhagen Holter Study. Methods The study included 632 men and women, between 55 and 75 years with no apparent heart disease or AF. Baseline standard 12-lead Electrocardiography (ECGs) were analyzed manually. Results The median follow-up time was 14.7 (14.5;14.9) years. A total of 68 cases of AF and 233 cases of death were recorded. The restricted cubic spline method showed a U-shaped association between P(AREA/DURATION)and rate of AF. The lowest quintile of P(AREA/DURATION)index in lead II was associated with increased rate of AF, HR 2.80 (1.64-4.79). The addition of the new index to the Framingham model for AF improved the model in this population. The P(AREA)in lead II in its lowest quintile was also associated with increased rate of AF, HR 2.16 (1.25-3.75), but did not improve the Framingham model. P(DURATION)and P-wave terminal force (PTF) were not significantly associated with AF. Conclusion A flat P wave as expressed by a small P(AREA/DURATION)index in lead II is associated with increased rate of incident AF beyond known AF risk factors.

AB - Background P-wave duration (P-DURATION) and P-wave area (P-AREA) have been linked to risk of atrial fibrillation (AF), but they do not improve the efficacy of Framingham AF risk score. We suggest the incorporation of both variables in one index, the P-wave area/P-wave duration (P-AREA(/)DURATION) index, which may be considered an expression of the average amplitude of the P wave that reflects aspects of P-wave morphology. Objective To assess the prognostic value of P-wave area/P-wave duration index (P(AREA/DURATION)index) in lead II together with other P-wave indices (PWIs) in incidence of AF in the Copenhagen Holter Study. Methods The study included 632 men and women, between 55 and 75 years with no apparent heart disease or AF. Baseline standard 12-lead Electrocardiography (ECGs) were analyzed manually. Results The median follow-up time was 14.7 (14.5;14.9) years. A total of 68 cases of AF and 233 cases of death were recorded. The restricted cubic spline method showed a U-shaped association between P(AREA/DURATION)and rate of AF. The lowest quintile of P(AREA/DURATION)index in lead II was associated with increased rate of AF, HR 2.80 (1.64-4.79). The addition of the new index to the Framingham model for AF improved the model in this population. The P(AREA)in lead II in its lowest quintile was also associated with increased rate of AF, HR 2.16 (1.25-3.75), but did not improve the Framingham model. P(DURATION)and P-wave terminal force (PTF) were not significantly associated with AF. Conclusion A flat P wave as expressed by a small P(AREA/DURATION)index in lead II is associated with increased rate of incident AF beyond known AF risk factors.

KW - atrial fibrillation

KW - electrocardiography

KW - P wave

KW - P-wave indices

KW - ECG LEAD PLACEMENT

KW - RISK

KW - ACCURACY

KW - DURATION

KW - POSITION

KW - FIBROSIS

KW - STROKE

KW - ECTOPY

KW - RHYTHM

U2 - 10.1111/anec.12751

DO - 10.1111/anec.12751

M3 - Journal article

C2 - 32274894

VL - 25

JO - Annals of Noninvasive Electrocardiology

JF - Annals of Noninvasive Electrocardiology

SN - 1542-474X

IS - 5

M1 - e12751

ER -

ID: 248331643