TY - JOUR

T1 - Research Recommendations for Selected IARC-Classified Agents

AU - Ward, Elizabeth M

AU - Schulte, Paul A

AU - Straif, Kurt

AU - Hopf, Nancy B

AU - Caldwell, Jane C

AU - Carreón, Tania

AU - Demarini, David M

AU - Fowler, Bruce A

AU - Goldstein, Bernard D

AU - Hemminki, Kari

AU - Husgafvel Pursiainen, Kirsti

AU - Kuempel, Eileen

AU - Lewtas, Joellen

AU - Lunn, Ruth M

AU - Lynge, Elsebeth

AU - McElvenny, Damien M

AU - Muhle, Hartwig

AU - Nakajima, Tamie

AU - Robertson, Larry W

AU - IARC Working Group

PY - 2010

Y1 - 2010

N2 - OBJECTIVES: There are some common occupational agents and exposure circumstances where evidence of carcinogenicity is substantial but not yet conclusive for humans. The objectives are to identify research gaps and needs for twenty agents prioritized for review based on evidence of widespread human exposures and potential carcinogenicity in animals or humans. DATA SOURCES: A systematic review was conducted of new data published since the most recent pertinent IARC monograph meeting. DATA EXTRACTION: Reviewers were charged with identifying data gaps and general and specific approaches to address them, focusing on research that would be important in resolving classification uncertainties. An expert meeting brought reviewers together to discuss each agent and the identified data gaps and approaches. DATA SYNTHESIS: Several overarching issues were identified that pertained to multiple agents; these included the importance of recognizing that carcinogenic agents can act through multiple toxicity pathways and mechanisms, including epigenetic mechanisms, oxidative stress and immuno- and hormonal modulation. CONCLUSIONS: Studies in occupational populations provide important opportunities to understand the mechanisms through which exogenous agents cause cancer and intervene to prevent human exposure and/or prevent or detect cancer among those already exposed. Scientific developments are likely to increase the challenges and complexities of carcinogen testing and evaluation in the future, and epidemiologic studies will be particularly critical to inform carcinogen classification and risk assessment processes.

AB - OBJECTIVES: There are some common occupational agents and exposure circumstances where evidence of carcinogenicity is substantial but not yet conclusive for humans. The objectives are to identify research gaps and needs for twenty agents prioritized for review based on evidence of widespread human exposures and potential carcinogenicity in animals or humans. DATA SOURCES: A systematic review was conducted of new data published since the most recent pertinent IARC monograph meeting. DATA EXTRACTION: Reviewers were charged with identifying data gaps and general and specific approaches to address them, focusing on research that would be important in resolving classification uncertainties. An expert meeting brought reviewers together to discuss each agent and the identified data gaps and approaches. DATA SYNTHESIS: Several overarching issues were identified that pertained to multiple agents; these included the importance of recognizing that carcinogenic agents can act through multiple toxicity pathways and mechanisms, including epigenetic mechanisms, oxidative stress and immuno- and hormonal modulation. CONCLUSIONS: Studies in occupational populations provide important opportunities to understand the mechanisms through which exogenous agents cause cancer and intervene to prevent human exposure and/or prevent or detect cancer among those already exposed. Scientific developments are likely to increase the challenges and complexities of carcinogen testing and evaluation in the future, and epidemiologic studies will be particularly critical to inform carcinogen classification and risk assessment processes.

U2 - 10.1289/ehp.0901828

DO - 10.1289/ehp.0901828

M3 - Journal article

C2 - 20562050

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

ER -