TY - JOUR

T1 - Risk of somatic hospitalization in parents after cancer in a child, a nationwide cohort study

AU - von Heymann, Annika

AU - Alef-Defoe, Sierra

AU - Salem, Hanin

AU - Andersen, Elisabeth Anne Wreford

AU - Dalton, Susanne Oksbjerg

AU - Schmiegelow, Kjeld

AU - Wadt, Karin A. W.

AU - Winther, Jeanette Falck

AU - Johansen, Christoffer

AU - Bidstrup, Pernille Envold

PY - 2022

Y1 - 2022

N2 - Objective The diagnosis of cancer in a child is a profoundly stressful experience. The impact on parents' somatic health, including lifestyle-related diseases, however, is unresolved. This paper assesses parents' risk of hospitalization with somatic disease after a child's cancer diagnosis. Methods We conducted a nationwide population- and register-based study with parents of all children under age 20 diagnosed with cancer in Denmark between 1998 and 2013 and parents of cancer-free children, matched (1:10) on child's age and family type. We estimated HR with 95% CI in Cox proportional hazard models for 13 major International Classification of Diseases-10 disease groups, selected stress- and lifestyle-related disease-groups, and investigated moderation by time since diagnosis, parental sex, and cancer type. Results Among n = 7797 parents of children with cancer compared with n = 74,388 parents of cancer-free children (51% mothers, mean age 42), we found no overall pattern of increased risk for 13 broad disease groups. We found increases in digestive system diseases (HR 1.06, 95% CI 1.01-1.12), genitourinary system diseases (HR 1.08, 95% CI 1.02-1.14), and neoplasms (HR 1.20, 95% CI 1.13-1.27), the latter attributable mostly to increased rates of tobacco-related cancers and mothers' diet-related cancers. Conclusions This is the first attempt to document the impact of childhood cancer on parents' somatic health. With the exception of increased risk for neoplasms, likely due to shared genetic or lifestyle factors, our findings offer the reassuring message, that the burden of caring for a child with cancer does not in general increase parents' risk for somatic diseases.

AB - Objective The diagnosis of cancer in a child is a profoundly stressful experience. The impact on parents' somatic health, including lifestyle-related diseases, however, is unresolved. This paper assesses parents' risk of hospitalization with somatic disease after a child's cancer diagnosis. Methods We conducted a nationwide population- and register-based study with parents of all children under age 20 diagnosed with cancer in Denmark between 1998 and 2013 and parents of cancer-free children, matched (1:10) on child's age and family type. We estimated HR with 95% CI in Cox proportional hazard models for 13 major International Classification of Diseases-10 disease groups, selected stress- and lifestyle-related disease-groups, and investigated moderation by time since diagnosis, parental sex, and cancer type. Results Among n = 7797 parents of children with cancer compared with n = 74,388 parents of cancer-free children (51% mothers, mean age 42), we found no overall pattern of increased risk for 13 broad disease groups. We found increases in digestive system diseases (HR 1.06, 95% CI 1.01-1.12), genitourinary system diseases (HR 1.08, 95% CI 1.02-1.14), and neoplasms (HR 1.20, 95% CI 1.13-1.27), the latter attributable mostly to increased rates of tobacco-related cancers and mothers' diet-related cancers. Conclusions This is the first attempt to document the impact of childhood cancer on parents' somatic health. With the exception of increased risk for neoplasms, likely due to shared genetic or lifestyle factors, our findings offer the reassuring message, that the burden of caring for a child with cancer does not in general increase parents' risk for somatic diseases.

KW - cancer

KW - children

KW - morbidity

KW - oncology

KW - parents

KW - stress

KW - STRESSFUL LIFE EVENTS

KW - PSYCHOLOGICAL STRESS

KW - MORTALITY

KW - HEALTH

KW - QUALITY

KW - CONTEXT

KW - UPDATE

KW - IMPACT

U2 - 10.1002/pon.5909

DO - 10.1002/pon.5909

M3 - Journal article

C2 - 35194898

VL - 31

SP - 1196

EP - 1203

JO - Psycho-Oncology

JF - Psycho-Oncology

SN - 1057-9249

IS - 7

ER -