Seventeen-years overview of breast cancer inside and outside screening in Denmark

Research output: Contribution to journalJournal articleResearchpeer-review

Laia Domingo, Katja Kemp Jacobsen, My Catarina von Euler-Chelpin, Ilse Vejborg, Walter Schwartz, Maria Sala, Elsebeth Lynge

Background. Long-term data on breast cancer detection in mammography screening programs are warranted to better understand the mechanisms by which screening changes the breast cancer pattern in the population. We aimed to analyze 17 years of breast cancer detection rates inside and outside screening in two Danish regions, emphasizing the influence of organizational differences of screening programs on the outcomes. Material and methods. We used data from two long-standing population-based mammography screening programs, Copenhagen and Fyn, in Denmark. Both programs offered biennial screening to women aged 50-69 years. We identified targeted, eligible, invited and participating women. We calculated screening detection and interval cancer rates for participants, and breast cancer incidence in non-screened women (= targeted women excluding participants) by biennial invitation rounds. Tumor characteristics were tabulated for each of the three groups of cancers. Results. Start of screening resulted in a prevalence peak in participants, followed by a decrease to a fairly stable detection rate in subsequent invitation rounds. A similar pattern was found for breast cancer incidence in non-screened women. In Fyn, non-screened women even had a higher rate than screening participants during the first three invitation rounds. The interval cancer rate was lower in Copenhagen than in Fyn, with an increase over time in Copenhagen, but not in Fyn. Screen-detected cancers showed tumor features related with a better prognosis than tumors detected otherwise, as more than 80% were smaller than 20 mm and estrogen receptor positive. Conclusion. Data from two long-standing population-based screening programs in Denmark illustrated that even if background breast cancer incidence and organization were rather similar, performance indicators of screening could be strongly influenced by inclusion criteria and participation rates. Detection rates should be interpreted with caution as they may be biased by selection into the screening population.
Original languageEnglish
JournalActa Oncologica
Volume52
Issue number1
Pages (from-to)48-56
Number of pages9
ISSN0284-186X
DOIs
Publication statusPublished - Jan 2013

    Research areas

  • Aged, Breast Neoplasms, Denmark, False Positive Reactions, Female, Humans, Incidence, Longitudinal Studies, Mammography, Mass Screening, Middle Aged, Prognosis, Program Evaluation, Receptors, Estrogen

ID: 46843752