Sex of prior children and risk of stillbirth in subsequent pregnancies

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Sex of prior children and risk of stillbirth in subsequent pregnancies. / Nielsen, Henriette Svarre; Mortensen, Laust Hvas; Nygaard, Ulrikka; Schnor, Ole; Christiansen, Ole Bjarne; Andersen, Anne-Marie Nybo.

In: Epidemiology, Vol. 21, No. 1, 2010, p. 114-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, HS, Mortensen, LH, Nygaard, U, Schnor, O, Christiansen, OB & Andersen, A-MN 2010, 'Sex of prior children and risk of stillbirth in subsequent pregnancies', Epidemiology, vol. 21, no. 1, pp. 114-7. https://doi.org/10.1097/EDE.0b013e3181c04dcf

APA

Nielsen, H. S., Mortensen, L. H., Nygaard, U., Schnor, O., Christiansen, O. B., & Andersen, A-M. N. (2010). Sex of prior children and risk of stillbirth in subsequent pregnancies. Epidemiology, 21(1), 114-7. https://doi.org/10.1097/EDE.0b013e3181c04dcf

Vancouver

Nielsen HS, Mortensen LH, Nygaard U, Schnor O, Christiansen OB, Andersen A-MN. Sex of prior children and risk of stillbirth in subsequent pregnancies. Epidemiology. 2010;21(1):114-7. https://doi.org/10.1097/EDE.0b013e3181c04dcf

Author

Nielsen, Henriette Svarre ; Mortensen, Laust Hvas ; Nygaard, Ulrikka ; Schnor, Ole ; Christiansen, Ole Bjarne ; Andersen, Anne-Marie Nybo. / Sex of prior children and risk of stillbirth in subsequent pregnancies. In: Epidemiology. 2010 ; Vol. 21, No. 1. pp. 114-7.

Bibtex

@article{2d047f109f0011df928f000ea68e967b,
title = "Sex of prior children and risk of stillbirth in subsequent pregnancies",
abstract = "BACKGROUND: Delivery of a boy has been reported to increase a woman's risk of recurrent miscarriage in subsequent pregnancies. We explored whether delivery of boys similarly increases the risk of a subsequent stillbirth. METHODS: We identified all Danish women delivering their first child (singleton) between 1980 and 1998 (n = 499,731) using the Danish Birth Registry. These women had subsequent singleton births through 2004 (n = 558,314). We assessed the risk of stillbirth conditional on sex of prior children. RESULTS: The risk of stillbirth was increased by 12% after deliver of boys compared with girls (relative risk = 1.12 [95% confidence interval = 1.02-1.23]). This association did not appear to be explained by maternal confounders. CONCLUSION: Stillbirth risk appears to be slightly higher among the pregnancies of women who have previously delivered a boy. One possible mechanism is maternal immune response to male-specific minor histocompatibility antigens initiated during pregnancies with boys.",
author = "Nielsen, {Henriette Svarre} and Mortensen, {Laust Hvas} and Ulrikka Nygaard and Ole Schnor and Christiansen, {Ole Bjarne} and Andersen, {Anne-Marie Nybo}",
year = "2010",
doi = "10.1097/EDE.0b013e3181c04dcf",
language = "English",
volume = "21",
pages = "114--7",
journal = "Epidemiology",
issn = "1044-3983",
publisher = "Lippincott Williams & Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - Sex of prior children and risk of stillbirth in subsequent pregnancies

AU - Nielsen, Henriette Svarre

AU - Mortensen, Laust Hvas

AU - Nygaard, Ulrikka

AU - Schnor, Ole

AU - Christiansen, Ole Bjarne

AU - Andersen, Anne-Marie Nybo

PY - 2010

Y1 - 2010

N2 - BACKGROUND: Delivery of a boy has been reported to increase a woman's risk of recurrent miscarriage in subsequent pregnancies. We explored whether delivery of boys similarly increases the risk of a subsequent stillbirth. METHODS: We identified all Danish women delivering their first child (singleton) between 1980 and 1998 (n = 499,731) using the Danish Birth Registry. These women had subsequent singleton births through 2004 (n = 558,314). We assessed the risk of stillbirth conditional on sex of prior children. RESULTS: The risk of stillbirth was increased by 12% after deliver of boys compared with girls (relative risk = 1.12 [95% confidence interval = 1.02-1.23]). This association did not appear to be explained by maternal confounders. CONCLUSION: Stillbirth risk appears to be slightly higher among the pregnancies of women who have previously delivered a boy. One possible mechanism is maternal immune response to male-specific minor histocompatibility antigens initiated during pregnancies with boys.

AB - BACKGROUND: Delivery of a boy has been reported to increase a woman's risk of recurrent miscarriage in subsequent pregnancies. We explored whether delivery of boys similarly increases the risk of a subsequent stillbirth. METHODS: We identified all Danish women delivering their first child (singleton) between 1980 and 1998 (n = 499,731) using the Danish Birth Registry. These women had subsequent singleton births through 2004 (n = 558,314). We assessed the risk of stillbirth conditional on sex of prior children. RESULTS: The risk of stillbirth was increased by 12% after deliver of boys compared with girls (relative risk = 1.12 [95% confidence interval = 1.02-1.23]). This association did not appear to be explained by maternal confounders. CONCLUSION: Stillbirth risk appears to be slightly higher among the pregnancies of women who have previously delivered a boy. One possible mechanism is maternal immune response to male-specific minor histocompatibility antigens initiated during pregnancies with boys.

U2 - 10.1097/EDE.0b013e3181c04dcf

DO - 10.1097/EDE.0b013e3181c04dcf

M3 - Journal article

C2 - 19901840

VL - 21

SP - 114

EP - 117

JO - Epidemiology

JF - Epidemiology

SN - 1044-3983

IS - 1

ER -

ID: 21162310