Shift work and overall and cause-specific mortality in the Danish nurse cohort

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Shift work and overall and cause-specific mortality in the Danish nurse cohort. / Jørgensen, Jeanette Therming; Karlsen, Sashia; Stayner, Leslie T.; Andersen, Johnnie; Andersen, Zorana Jovanovic.

In: Scandinavian Journal of Work, Environment & Health, Vol. 43, No. 2, 01.03.2017, p. 117-126.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jørgensen, JT, Karlsen, S, Stayner, LT, Andersen, J & Andersen, ZJ 2017, 'Shift work and overall and cause-specific mortality in the Danish nurse cohort' Scandinavian Journal of Work, Environment & Health, vol. 43, no. 2, pp. 117-126. https://doi.org/10.5271/sjweh.3612

APA

Jørgensen, J. T., Karlsen, S., Stayner, L. T., Andersen, J., & Andersen, Z. J. (2017). Shift work and overall and cause-specific mortality in the Danish nurse cohort. Scandinavian Journal of Work, Environment & Health, 43(2), 117-126. https://doi.org/10.5271/sjweh.3612

Vancouver

Jørgensen JT, Karlsen S, Stayner LT, Andersen J, Andersen ZJ. Shift work and overall and cause-specific mortality in the Danish nurse cohort. Scandinavian Journal of Work, Environment & Health. 2017 Mar 1;43(2):117-126. https://doi.org/10.5271/sjweh.3612

Author

Jørgensen, Jeanette Therming ; Karlsen, Sashia ; Stayner, Leslie T. ; Andersen, Johnnie ; Andersen, Zorana Jovanovic. / Shift work and overall and cause-specific mortality in the Danish nurse cohort. In: Scandinavian Journal of Work, Environment & Health. 2017 ; Vol. 43, No. 2. pp. 117-126.

Bibtex

@article{8b4a681b1c864080b5996b1822462556,
title = "Shift work and overall and cause-specific mortality in the Danish nurse cohort",
abstract = "Objectives: Evidence of an effect of shift work on all-cause and cause-specific mortality is inconsistent. This study aims to examine whether shift work is associated with increased all-cause and cause-specific mortality. Methods: We linked 28 731 female nurses (age ≥44 years), recruited in 1993 or 1999 from the Danish nurse cohort where they reported information on shift work (night, evening, rotating, or day), to the Danish Register of Causes of Death to identify deaths up to 2013. We used Cox regression models with age as the underlying scale to examine the associations between night, evening, and rotating shift work (compared to day shift work) and all-cause and cause-specific mortality in models adjusted for potentially confounding variables. Results: Of 18 015 nurses included in this study, 1616 died during the study time period from the following causes: cardiovascular disease (N=217), cancer (N= 945), diabetes (N=20), Alzheimer's disease or dementia (N=33), and psychiatric diseases (N=67). We found that working night [hazard ratio (HR) 1.26, 95{\%} confidence interval 95{\%} CI) 1.05-1.51] or evening (HR 1.29, 95{\%} CI 1.11-1.49) shifts was associated with a significant increase in all-cause mortality when compared to working day shift. We found a significant association of night shift work with cardiovascular disease (HR 1.71, 95{\%} CI 1.09-2.69) and diabetes (HR 12.0, 95{\%} CI 3.17-45.2, based on 8 cases) and none with overall cancer mortality (HR 1.05, 95{\%} CI 0.81-1.35) or mortality from psychiatric diseases (HR 1.17, 95{\%} CI 0.47-2.92). Finally, we found strong association between evening (HR 4.28, 95{\%} CI 1.62-11.3) and rotating (HR 5.39, 95{\%} CI 2.35-12.3) shift work and mortality from Alzheimer's disease and dementia (based on 8 and 14 deaths among evening and rotating shift workers, respectively). Conclusions: Women working night and evening shifts have increased all-cause, cardiovascular, diabetes, and Alzheimer's and dementia mortality.",
keywords = "Journal Article",
author = "J{\o}rgensen, {Jeanette Therming} and Sashia Karlsen and Stayner, {Leslie T.} and Johnnie Andersen and Andersen, {Zorana Jovanovic}",
year = "2017",
month = "3",
day = "1",
doi = "10.5271/sjweh.3612",
language = "English",
volume = "43",
pages = "117--126",
journal = "Scandinavian Journal of Work, Environment & Health",
issn = "0355-3140",
publisher = "Tyoterveyslaitos",
number = "2",

}

RIS

TY - JOUR

T1 - Shift work and overall and cause-specific mortality in the Danish nurse cohort

AU - Jørgensen, Jeanette Therming

AU - Karlsen, Sashia

AU - Stayner, Leslie T.

AU - Andersen, Johnnie

AU - Andersen, Zorana Jovanovic

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Objectives: Evidence of an effect of shift work on all-cause and cause-specific mortality is inconsistent. This study aims to examine whether shift work is associated with increased all-cause and cause-specific mortality. Methods: We linked 28 731 female nurses (age ≥44 years), recruited in 1993 or 1999 from the Danish nurse cohort where they reported information on shift work (night, evening, rotating, or day), to the Danish Register of Causes of Death to identify deaths up to 2013. We used Cox regression models with age as the underlying scale to examine the associations between night, evening, and rotating shift work (compared to day shift work) and all-cause and cause-specific mortality in models adjusted for potentially confounding variables. Results: Of 18 015 nurses included in this study, 1616 died during the study time period from the following causes: cardiovascular disease (N=217), cancer (N= 945), diabetes (N=20), Alzheimer's disease or dementia (N=33), and psychiatric diseases (N=67). We found that working night [hazard ratio (HR) 1.26, 95% confidence interval 95% CI) 1.05-1.51] or evening (HR 1.29, 95% CI 1.11-1.49) shifts was associated with a significant increase in all-cause mortality when compared to working day shift. We found a significant association of night shift work with cardiovascular disease (HR 1.71, 95% CI 1.09-2.69) and diabetes (HR 12.0, 95% CI 3.17-45.2, based on 8 cases) and none with overall cancer mortality (HR 1.05, 95% CI 0.81-1.35) or mortality from psychiatric diseases (HR 1.17, 95% CI 0.47-2.92). Finally, we found strong association between evening (HR 4.28, 95% CI 1.62-11.3) and rotating (HR 5.39, 95% CI 2.35-12.3) shift work and mortality from Alzheimer's disease and dementia (based on 8 and 14 deaths among evening and rotating shift workers, respectively). Conclusions: Women working night and evening shifts have increased all-cause, cardiovascular, diabetes, and Alzheimer's and dementia mortality.

AB - Objectives: Evidence of an effect of shift work on all-cause and cause-specific mortality is inconsistent. This study aims to examine whether shift work is associated with increased all-cause and cause-specific mortality. Methods: We linked 28 731 female nurses (age ≥44 years), recruited in 1993 or 1999 from the Danish nurse cohort where they reported information on shift work (night, evening, rotating, or day), to the Danish Register of Causes of Death to identify deaths up to 2013. We used Cox regression models with age as the underlying scale to examine the associations between night, evening, and rotating shift work (compared to day shift work) and all-cause and cause-specific mortality in models adjusted for potentially confounding variables. Results: Of 18 015 nurses included in this study, 1616 died during the study time period from the following causes: cardiovascular disease (N=217), cancer (N= 945), diabetes (N=20), Alzheimer's disease or dementia (N=33), and psychiatric diseases (N=67). We found that working night [hazard ratio (HR) 1.26, 95% confidence interval 95% CI) 1.05-1.51] or evening (HR 1.29, 95% CI 1.11-1.49) shifts was associated with a significant increase in all-cause mortality when compared to working day shift. We found a significant association of night shift work with cardiovascular disease (HR 1.71, 95% CI 1.09-2.69) and diabetes (HR 12.0, 95% CI 3.17-45.2, based on 8 cases) and none with overall cancer mortality (HR 1.05, 95% CI 0.81-1.35) or mortality from psychiatric diseases (HR 1.17, 95% CI 0.47-2.92). Finally, we found strong association between evening (HR 4.28, 95% CI 1.62-11.3) and rotating (HR 5.39, 95% CI 2.35-12.3) shift work and mortality from Alzheimer's disease and dementia (based on 8 and 14 deaths among evening and rotating shift workers, respectively). Conclusions: Women working night and evening shifts have increased all-cause, cardiovascular, diabetes, and Alzheimer's and dementia mortality.

KW - Journal Article

U2 - 10.5271/sjweh.3612

DO - 10.5271/sjweh.3612

M3 - Journal article

VL - 43

SP - 117

EP - 126

JO - Scandinavian Journal of Work, Environment & Health

JF - Scandinavian Journal of Work, Environment & Health

SN - 0355-3140

IS - 2

ER -

ID: 177087555