Small molecules from spiders used as chemical probes

Research output: Contribution to journalReviewResearchpeer-review

Spiders are important species in ecological systems and as major predators of insects they are endowed with a plethora of low-molecular-weight natural products having intriguing biological activities. The isolation and biological characterization of these entities are well established, however, only very recently have these compounds been used as templates for the design, synthesis, and biological evaluation of synthetic analogues. In contrast, the investigation of compounds responsible for chemical communication between spiders is far less developed, but recently new light has been shed onto the area of pheromones and allomones from spiders. Herein, we recapitulate these recent results, put them into perspective with previous findings, and provide an outlook for future studies of these chemotypes.
Original languageEnglish
JournalAngewandte Chemie International Edition
Issue number48
Pages (from-to)11296-11311
Publication statusPublished - 25 Nov 2011

Bibliographical note

Keywords: allemones; pheromones; polyamines; spiders; toxins

ID: 35411825