TY - JOUR

T1 - Smoking-adjusted risk of kidney cancer by occupation

T2 - a population-based cohort study of Nordic men

AU - Michalek, Irmina Maria

AU - Kinnunen, Tarja I.

AU - Kjaerheim, Kristina

AU - Lynge, Elsebeth

AU - Martinsen, Jan Ivar

AU - Sparen, Pär

AU - Tryggvadottir, Laufey

AU - Weiderpass, Elisabete

AU - Pukkala, Eero

N1 - Publisher Copyright: © 2020, © 2020 Acta Oncologica Foundation.

PY - 2020

Y1 - 2020

N2 - Background: Evidence suggests that among some occupational groups, there is an elevated risk of kidney cancer. This might, however, derive from a difference in smoking habits across occupational groups. The objective of this study was to determine smoking-adjusted occupational variation in the incidence of kidney cancer in Nordic males. Material and Methods: The source population for this study consisted of 7.4 million men from Denmark, Iceland, Finland, Norway, and Sweden. Data on occupation were obtained from national censuses conducted in the years 1960–1990. Data on cancer cases came from national cancer registries. A proxy for the occupation-specific smoking prevalence among all Nordic men was calculated based on the occupation-specific smoking prevalence and lung cancer incidence data for Finnish men. Smoking-adjusted standardized incidence ratio (SIRadj) with 95% confidence intervals (95%CI) were calculated for each occupational group. Results: The highest SIRadj estimates were observed in dentists (1.32, 95%CI 1.06–1.62), journalists (1.20, 95%CI 1.00–1.42), physicians (1.19, 95%CI 1.03–1.36), public safety workers (1.18, 95%CI 1.10–1.26), administrators (1.17, 95%CI 1.13–1.22), military personnel (1.16, 95%CI 1.05–1.28), and religious workers (1.17, 95%CI 1.09–1.26). The lowest SIRadj was observed among forestry workers (0.82, 95%CI 0.76–0.88). Conclusions: Tobacco smoking plays an important role in the occupational variation in the risk of kidney cancer. The smoking-adjusted incidence of kidney cancer was increased in dentists, physicians, journalists, administrators, and public safety workers.

AB - Background: Evidence suggests that among some occupational groups, there is an elevated risk of kidney cancer. This might, however, derive from a difference in smoking habits across occupational groups. The objective of this study was to determine smoking-adjusted occupational variation in the incidence of kidney cancer in Nordic males. Material and Methods: The source population for this study consisted of 7.4 million men from Denmark, Iceland, Finland, Norway, and Sweden. Data on occupation were obtained from national censuses conducted in the years 1960–1990. Data on cancer cases came from national cancer registries. A proxy for the occupation-specific smoking prevalence among all Nordic men was calculated based on the occupation-specific smoking prevalence and lung cancer incidence data for Finnish men. Smoking-adjusted standardized incidence ratio (SIRadj) with 95% confidence intervals (95%CI) were calculated for each occupational group. Results: The highest SIRadj estimates were observed in dentists (1.32, 95%CI 1.06–1.62), journalists (1.20, 95%CI 1.00–1.42), physicians (1.19, 95%CI 1.03–1.36), public safety workers (1.18, 95%CI 1.10–1.26), administrators (1.17, 95%CI 1.13–1.22), military personnel (1.16, 95%CI 1.05–1.28), and religious workers (1.17, 95%CI 1.09–1.26). The lowest SIRadj was observed among forestry workers (0.82, 95%CI 0.76–0.88). Conclusions: Tobacco smoking plays an important role in the occupational variation in the risk of kidney cancer. The smoking-adjusted incidence of kidney cancer was increased in dentists, physicians, journalists, administrators, and public safety workers.

U2 - 10.1080/0284186X.2020.1714722

DO - 10.1080/0284186X.2020.1714722

M3 - Journal article

C2 - 32009517

AN - SCOPUS:85078901734

VL - 59

SP - 582

EP - 587

JO - Acta Oncologica

JF - Acta Oncologica

SN - 1100-1704

IS - 5

ER -