Subclinical thyroid dysfunction and incident diabetes

Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies

Research output: Contribution to journal › Review › Research › peer-review

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Subclinical thyroid dysfunction and incident diabetes : a systematic review and an individual participant data analysis of prospective cohort studies. / Alwan, Heba; Villoz, Fanny; Feller, Martin; Dullaart, Robin P.F.; Bakker, Stephan J.L.; Peeters, Robin P.; Kavousi, Maryam; Bauer, Douglas C.; Cappola, Anne R.; Yeap, Bu B.; Walsh, John P.; Brown, Suzanne J.; Ceresini, Graziano; Ferrucci, Luigi; Gussekloo, Jacobijn; Trompet, Stella; Iacoviello, Massimo; Moon, Jae Hoon; Razvi, Salman; Bensenor, Isabela M.; Azizi, Fereidoun; Amouzegar, Atieh; Valdés, Sergio; Colomo, Natalia; Wareham, Nick J.; Jukema, J. Wouter; Westendorp, Rudi G.J.; Kim, Ki Woong; Rodondi, Nicolas; Del Giovane, Cinzia; Thyroid Studies Collaboration.

In: European Journal of Endocrinology, Vol. 187, No. 5, 2022, p. S35-S46.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Alwan, H, Villoz, F, Feller, M, Dullaart, RPF, Bakker, SJL, Peeters, RP, Kavousi, M, Bauer, DC, Cappola, AR, Yeap, BB, Walsh, JP, Brown, SJ, Ceresini, G, Ferrucci, L, Gussekloo, J, Trompet, S, Iacoviello, M, Moon, JH, Razvi, S, Bensenor, IM, Azizi, F, Amouzegar, A, Valdés, S, Colomo, N, Wareham, NJ, Jukema, JW, Westendorp, RGJ, Kim, KW, Rodondi, N, Del Giovane, C & Thyroid Studies Collaboration 2022, 'Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies', European Journal of Endocrinology, vol. 187, no. 5, pp. S35-S46. https://doi.org/10.1530/EJE-22-0523

APA

Alwan, H., Villoz, F., Feller, M., Dullaart, R. P. F., Bakker, S. J. L., Peeters, R. P., Kavousi, M., Bauer, D. C., Cappola, A. R., Yeap, B. B., Walsh, J. P., Brown, S. J., Ceresini, G., Ferrucci, L., Gussekloo, J., Trompet, S., Iacoviello, M., Moon, J. H., Razvi, S., ... Thyroid Studies Collaboration (2022). Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies. European Journal of Endocrinology, 187(5), S35-S46. https://doi.org/10.1530/EJE-22-0523

Vancouver

Alwan H, Villoz F, Feller M, Dullaart RPF, Bakker SJL, Peeters RP et al. Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies. European Journal of Endocrinology. 2022;187(5):S35-S46. https://doi.org/10.1530/EJE-22-0523

Author

Alwan, Heba ; Villoz, Fanny ; Feller, Martin ; Dullaart, Robin P.F. ; Bakker, Stephan J.L. ; Peeters, Robin P. ; Kavousi, Maryam ; Bauer, Douglas C. ; Cappola, Anne R. ; Yeap, Bu B. ; Walsh, John P. ; Brown, Suzanne J. ; Ceresini, Graziano ; Ferrucci, Luigi ; Gussekloo, Jacobijn ; Trompet, Stella ; Iacoviello, Massimo ; Moon, Jae Hoon ; Razvi, Salman ; Bensenor, Isabela M. ; Azizi, Fereidoun ; Amouzegar, Atieh ; Valdés, Sergio ; Colomo, Natalia ; Wareham, Nick J. ; Jukema, J. Wouter ; Westendorp, Rudi G.J. ; Kim, Ki Woong ; Rodondi, Nicolas ; Del Giovane, Cinzia ; Thyroid Studies Collaboration. / Subclinical thyroid dysfunction and incident diabetes : a systematic review and an individual participant data analysis of prospective cohort studies. In: European Journal of Endocrinology. 2022 ; Vol. 187, No. 5. pp. S35-S46.

Bibtex

@article{d8ae9624ce8346acaa83a032d72c3a4b,

title = "Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies",

abstract = "Objective: Few prospective studies have assessed whether individuals with subclinical thyroid dysfunction are more likely to develop diabetes, with conflicting results. In this study, we conducted a systematic review of the literature and an individual participant data analysis of multiple prospective cohorts to investigate the association between subclinical thyroid dysfunction and incident diabetes. Methods: We performed a systematic review of the literature in Medline, Embase, and the Cochrane Library from inception to February 11, 2022. A two-stage individual participant data analysis was conducted to compare participants with subclinical hypothyroidism and subclinical hyperthyroidism vs euthyroidism at baseline and the adjusted risk of developing diabetes at follow-up. Results: Among 61 178 adults from 18 studies, 49% were females, mean age was 58 years, and mean follow-up time was 8.2 years. At the last available follow-up, there was no association between subclinical hypothyroidism and incidence of diabetes (odds ratio (OR) = 1.02, 95% CI: 0.88-1.17, I2 = 0%) or subclinical hyperthyroidism and incidence of diabetes (OR = 1.03, 95% CI: 0.82-1.30, I2 = 0%), in age- and sex-adjusted analyses. Time-to-event analysis showed similar results (hazard ratio for subclinical hypothyroidism: 0.98, 95% CI: 0.87-1.11; hazard ratio for subclinical hyperthyroidism: 1.07, 95% CI: 0.88-1.29). The results were robust in all sub-group and sensitivity analyses. Conclusions: This is the largest systematic review and individual participant data analysis to date investigating the prospective association between subclinical thyroid dysfunction and diabetes. We did not find an association between subclinical thyroid dysfunction and incident diabetes. Our results do not support screening patients with subclinical thyroid dysfunction for diabetes. Significance statement: Evidence is conflicting regarding whether an association exists between subclinical thyroid dysfunction and incident diabetes. We therefore aimed to investigate whether individuals with subclinical thyroid dysfunction are more prone to develop diabetes in the long run as compared to euthyroid individuals. We included data from 18 international cohort studies with 61 178 adults and a mean follow-up time of 8.2 years. We did not find an association between subclinical hypothyroidism or subclinical hyperthyroidism at baseline and incident diabetes at follow-up. Our results have clinical implications as they neither support screening patients with subclinical thyroid dysfunction for diabetes nor treating them in the hope of preventing diabetes in the future.",

author = "Heba Alwan and Fanny Villoz and Martin Feller and Dullaart, {Robin P.F.} and Bakker, {Stephan J.L.} and Peeters, {Robin P.} and Maryam Kavousi and Bauer, {Douglas C.} and Cappola, {Anne R.} and Yeap, {Bu B.} and Walsh, {John P.} and Brown, {Suzanne J.} and Graziano Ceresini and Luigi Ferrucci and Jacobijn Gussekloo and Stella Trompet and Massimo Iacoviello and Moon, {Jae Hoon} and Salman Razvi and Bensenor, {Isabela M.} and Fereidoun Azizi and Atieh Amouzegar and Sergio Vald{\'e}s and Natalia Colomo and Wareham, {Nick J.} and Jukema, {J. Wouter} and Westendorp, {Rudi G.J.} and Kim, {Ki Woong} and Nicolas Rodondi and {Del Giovane}, Cinzia and {Thyroid Studies Collaboration}",

year = "2022",

doi = "10.1530/EJE-22-0523",

language = "English",

volume = "187",

pages = "S35--S46",

journal = "European Journal of Endocrinology",

issn = "0804-4643",

publisher = "BioScientifica Ltd.",

number = "5",

}

RIS

TY - JOUR

T1 - Subclinical thyroid dysfunction and incident diabetes

T2 - a systematic review and an individual participant data analysis of prospective cohort studies

AU - Alwan, Heba

AU - Villoz, Fanny

AU - Feller, Martin

AU - Dullaart, Robin P.F.

AU - Bakker, Stephan J.L.

AU - Peeters, Robin P.

AU - Kavousi, Maryam

AU - Bauer, Douglas C.

AU - Cappola, Anne R.

AU - Yeap, Bu B.

AU - Walsh, John P.

AU - Brown, Suzanne J.

AU - Ceresini, Graziano

AU - Ferrucci, Luigi

AU - Gussekloo, Jacobijn

AU - Trompet, Stella

AU - Iacoviello, Massimo

AU - Moon, Jae Hoon

AU - Razvi, Salman

AU - Bensenor, Isabela M.

AU - Azizi, Fereidoun

AU - Amouzegar, Atieh

AU - Valdés, Sergio

AU - Colomo, Natalia

AU - Wareham, Nick J.

AU - Jukema, J. Wouter

AU - Westendorp, Rudi G.J.

AU - Kim, Ki Woong

AU - Rodondi, Nicolas

AU - Del Giovane, Cinzia

AU - Thyroid Studies Collaboration

PY - 2022

Y1 - 2022

N2 - Objective: Few prospective studies have assessed whether individuals with subclinical thyroid dysfunction are more likely to develop diabetes, with conflicting results. In this study, we conducted a systematic review of the literature and an individual participant data analysis of multiple prospective cohorts to investigate the association between subclinical thyroid dysfunction and incident diabetes. Methods: We performed a systematic review of the literature in Medline, Embase, and the Cochrane Library from inception to February 11, 2022. A two-stage individual participant data analysis was conducted to compare participants with subclinical hypothyroidism and subclinical hyperthyroidism vs euthyroidism at baseline and the adjusted risk of developing diabetes at follow-up. Results: Among 61 178 adults from 18 studies, 49% were females, mean age was 58 years, and mean follow-up time was 8.2 years. At the last available follow-up, there was no association between subclinical hypothyroidism and incidence of diabetes (odds ratio (OR) = 1.02, 95% CI: 0.88-1.17, I2 = 0%) or subclinical hyperthyroidism and incidence of diabetes (OR = 1.03, 95% CI: 0.82-1.30, I2 = 0%), in age- and sex-adjusted analyses. Time-to-event analysis showed similar results (hazard ratio for subclinical hypothyroidism: 0.98, 95% CI: 0.87-1.11; hazard ratio for subclinical hyperthyroidism: 1.07, 95% CI: 0.88-1.29). The results were robust in all sub-group and sensitivity analyses. Conclusions: This is the largest systematic review and individual participant data analysis to date investigating the prospective association between subclinical thyroid dysfunction and diabetes. We did not find an association between subclinical thyroid dysfunction and incident diabetes. Our results do not support screening patients with subclinical thyroid dysfunction for diabetes. Significance statement: Evidence is conflicting regarding whether an association exists between subclinical thyroid dysfunction and incident diabetes. We therefore aimed to investigate whether individuals with subclinical thyroid dysfunction are more prone to develop diabetes in the long run as compared to euthyroid individuals. We included data from 18 international cohort studies with 61 178 adults and a mean follow-up time of 8.2 years. We did not find an association between subclinical hypothyroidism or subclinical hyperthyroidism at baseline and incident diabetes at follow-up. Our results have clinical implications as they neither support screening patients with subclinical thyroid dysfunction for diabetes nor treating them in the hope of preventing diabetes in the future.

AB - Objective: Few prospective studies have assessed whether individuals with subclinical thyroid dysfunction are more likely to develop diabetes, with conflicting results. In this study, we conducted a systematic review of the literature and an individual participant data analysis of multiple prospective cohorts to investigate the association between subclinical thyroid dysfunction and incident diabetes. Methods: We performed a systematic review of the literature in Medline, Embase, and the Cochrane Library from inception to February 11, 2022. A two-stage individual participant data analysis was conducted to compare participants with subclinical hypothyroidism and subclinical hyperthyroidism vs euthyroidism at baseline and the adjusted risk of developing diabetes at follow-up. Results: Among 61 178 adults from 18 studies, 49% were females, mean age was 58 years, and mean follow-up time was 8.2 years. At the last available follow-up, there was no association between subclinical hypothyroidism and incidence of diabetes (odds ratio (OR) = 1.02, 95% CI: 0.88-1.17, I2 = 0%) or subclinical hyperthyroidism and incidence of diabetes (OR = 1.03, 95% CI: 0.82-1.30, I2 = 0%), in age- and sex-adjusted analyses. Time-to-event analysis showed similar results (hazard ratio for subclinical hypothyroidism: 0.98, 95% CI: 0.87-1.11; hazard ratio for subclinical hyperthyroidism: 1.07, 95% CI: 0.88-1.29). The results were robust in all sub-group and sensitivity analyses. Conclusions: This is the largest systematic review and individual participant data analysis to date investigating the prospective association between subclinical thyroid dysfunction and diabetes. We did not find an association between subclinical thyroid dysfunction and incident diabetes. Our results do not support screening patients with subclinical thyroid dysfunction for diabetes. Significance statement: Evidence is conflicting regarding whether an association exists between subclinical thyroid dysfunction and incident diabetes. We therefore aimed to investigate whether individuals with subclinical thyroid dysfunction are more prone to develop diabetes in the long run as compared to euthyroid individuals. We included data from 18 international cohort studies with 61 178 adults and a mean follow-up time of 8.2 years. We did not find an association between subclinical hypothyroidism or subclinical hyperthyroidism at baseline and incident diabetes at follow-up. Our results have clinical implications as they neither support screening patients with subclinical thyroid dysfunction for diabetes nor treating them in the hope of preventing diabetes in the future.

U2 - 10.1530/EJE-22-0523

DO - 10.1530/EJE-22-0523

M3 - Review

C2 - 36070417

AN - SCOPUS:85139571876

VL - 187

SP - S35-S46

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 5

ER -

ID: 337205840

Department of Public Health