Synthesis and characterization of an epimer of tacrolimus, an immunosuppressive drug

Research output: Contribution to journalJournal articleResearchpeer-review

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Synthesis and characterization of an epimer of tacrolimus, an immunosuppressive drug. / Skytte, Dorthe Mondrup; Frydenvang, Karla Andrea; Hansen, Liselotte; Nielsen, Peter G; Jaroszewski, Jerzy W.

In: Journal of Natural Products, Vol. 73, No. 4, 18.02.2010, p. 776-779.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Skytte, DM, Frydenvang, KA, Hansen, L, Nielsen, PG & Jaroszewski, JW 2010, 'Synthesis and characterization of an epimer of tacrolimus, an immunosuppressive drug', Journal of Natural Products, vol. 73, no. 4, pp. 776-779. https://doi.org/10.1021/np9007975

APA

Skytte, D. M., Frydenvang, K. A., Hansen, L., Nielsen, P. G., & Jaroszewski, J. W. (2010). Synthesis and characterization of an epimer of tacrolimus, an immunosuppressive drug. Journal of Natural Products, 73(4), 776-779. https://doi.org/10.1021/np9007975

Vancouver

Skytte DM, Frydenvang KA, Hansen L, Nielsen PG, Jaroszewski JW. Synthesis and characterization of an epimer of tacrolimus, an immunosuppressive drug. Journal of Natural Products. 2010 Feb 18;73(4):776-779. https://doi.org/10.1021/np9007975

Author

Skytte, Dorthe Mondrup ; Frydenvang, Karla Andrea ; Hansen, Liselotte ; Nielsen, Peter G ; Jaroszewski, Jerzy W. / Synthesis and characterization of an epimer of tacrolimus, an immunosuppressive drug. In: Journal of Natural Products. 2010 ; Vol. 73, No. 4. pp. 776-779.

Bibtex

@article{b8e200604c5e11df928f000ea68e967b,
title = "Synthesis and characterization of an epimer of tacrolimus, an immunosuppressive drug",
abstract = "8-Epitacrolimus (2), a new l-pipecolic acid macrolide lactone, was obtained by base-catalyzed epimerization of tacrolimus (FK-506, 1), an important immunosuppressive drug, and its structure determined by a single-crystal X-ray diffraction method. The compound was fully characterized by spectroscopic techniques. The epimer is of importance due to its potential biological effects as well as because of its possible formation during formulation, handling, and use of tacrolimus products.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Skytte, {Dorthe Mondrup} and Frydenvang, {Karla Andrea} and Liselotte Hansen and Nielsen, {Peter G} and Jaroszewski, {Jerzy W}",
year = "2010",
month = "2",
day = "18",
doi = "10.1021/np9007975",
language = "English",
volume = "73",
pages = "776--779",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "4",

}

RIS

TY - JOUR

T1 - Synthesis and characterization of an epimer of tacrolimus, an immunosuppressive drug

AU - Skytte, Dorthe Mondrup

AU - Frydenvang, Karla Andrea

AU - Hansen, Liselotte

AU - Nielsen, Peter G

AU - Jaroszewski, Jerzy W

PY - 2010/2/18

Y1 - 2010/2/18

N2 - 8-Epitacrolimus (2), a new l-pipecolic acid macrolide lactone, was obtained by base-catalyzed epimerization of tacrolimus (FK-506, 1), an important immunosuppressive drug, and its structure determined by a single-crystal X-ray diffraction method. The compound was fully characterized by spectroscopic techniques. The epimer is of importance due to its potential biological effects as well as because of its possible formation during formulation, handling, and use of tacrolimus products.

AB - 8-Epitacrolimus (2), a new l-pipecolic acid macrolide lactone, was obtained by base-catalyzed epimerization of tacrolimus (FK-506, 1), an important immunosuppressive drug, and its structure determined by a single-crystal X-ray diffraction method. The compound was fully characterized by spectroscopic techniques. The epimer is of importance due to its potential biological effects as well as because of its possible formation during formulation, handling, and use of tacrolimus products.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1021/np9007975

DO - 10.1021/np9007975

M3 - Journal article

C2 - 20166703

VL - 73

SP - 776

EP - 779

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 4

ER -

ID: 19367332