The adaptability of tendon to loading differs in men and women

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The adaptability of tendon to loading differs in men and women. / Magnusson, S Peter; Hansen, Mette; Langberg, Henning; Miller, Ben; Haraldsson, Bjarki; Westh, Eva Kjoeller; Koskinen, Satu; Aagaard, Per; Kjaer, Michael.

In: International Journal of Experimental Pathology, Vol. 88, No. 4, 2007, p. 237-40.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Magnusson, SP, Hansen, M, Langberg, H, Miller, B, Haraldsson, B, Westh, EK, Koskinen, S, Aagaard, P & Kjaer, M 2007, 'The adaptability of tendon to loading differs in men and women', International Journal of Experimental Pathology, vol. 88, no. 4, pp. 237-40. https://doi.org/10.1111/j.1365-2613.2007.00551.x

APA

Magnusson, S. P., Hansen, M., Langberg, H., Miller, B., Haraldsson, B., Westh, E. K., Koskinen, S., Aagaard, P., & Kjaer, M. (2007). The adaptability of tendon to loading differs in men and women. International Journal of Experimental Pathology, 88(4), 237-40. https://doi.org/10.1111/j.1365-2613.2007.00551.x

Vancouver

Magnusson SP, Hansen M, Langberg H, Miller B, Haraldsson B, Westh EK et al. The adaptability of tendon to loading differs in men and women. International Journal of Experimental Pathology. 2007;88(4):237-40. https://doi.org/10.1111/j.1365-2613.2007.00551.x

Author

Magnusson, S Peter ; Hansen, Mette ; Langberg, Henning ; Miller, Ben ; Haraldsson, Bjarki ; Westh, Eva Kjoeller ; Koskinen, Satu ; Aagaard, Per ; Kjaer, Michael. / The adaptability of tendon to loading differs in men and women. In: International Journal of Experimental Pathology. 2007 ; Vol. 88, No. 4. pp. 237-40.

Bibtex

@article{e2112eafd81842458388ad7dcb1a8c25,
title = "The adaptability of tendon to loading differs in men and women",
abstract = "The reason why women sustain more soft tissue injury than men during physical activity is unknown. Connective tissue properties and extracellular matrix adaptability in human tendon were investigated in models that addressed biochemical, physiological and biomechanical aspects of tendon connective tissue in response to mechanical loading. Habitual training resulted in a larger patellar tendon in men but not in women. Following an acute bout of exercise, men had an elevated tendon collagen synthesis rate and this effect was less pronounced or absent in women. Moreover, levels of circulating oestrogen affected the acute exercise-related increase in collagen synthesis. Finally, the mechanical strength of isolated tendon collagen fascicles in men surpassed that of women. Thus, compared to men, women have (i) an attenuated tendon hypertrophy response to habitual training; (ii) a lower tendon collagen synthesis rate following acute exercise; (iii) a rate of tendon collagen synthesis which is further attenuated with elevated estradiol levels; and (iv) a lower mechanical strength of their tendons. These data indicate that tendons in women have a lower rate of new connective tissue formation, respond less to mechanical loading, and have a lower mechanical strength, which may leave the tissue more susceptible to injury.",
keywords = "Adaptation, Physiological, Collagen, Exercise, Female, Humans, Male, Sex Characteristics, Stress, Mechanical, Tendons, Weight-Bearing",
author = "Magnusson, {S Peter} and Mette Hansen and Henning Langberg and Ben Miller and Bjarki Haraldsson and Westh, {Eva Kjoeller} and Satu Koskinen and Per Aagaard and Michael Kjaer",
year = "2007",
doi = "10.1111/j.1365-2613.2007.00551.x",
language = "English",
volume = "88",
pages = "237--40",
journal = "International Journal of Experimental Pathology",
issn = "0959-9673",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - The adaptability of tendon to loading differs in men and women

AU - Magnusson, S Peter

AU - Hansen, Mette

AU - Langberg, Henning

AU - Miller, Ben

AU - Haraldsson, Bjarki

AU - Westh, Eva Kjoeller

AU - Koskinen, Satu

AU - Aagaard, Per

AU - Kjaer, Michael

PY - 2007

Y1 - 2007

N2 - The reason why women sustain more soft tissue injury than men during physical activity is unknown. Connective tissue properties and extracellular matrix adaptability in human tendon were investigated in models that addressed biochemical, physiological and biomechanical aspects of tendon connective tissue in response to mechanical loading. Habitual training resulted in a larger patellar tendon in men but not in women. Following an acute bout of exercise, men had an elevated tendon collagen synthesis rate and this effect was less pronounced or absent in women. Moreover, levels of circulating oestrogen affected the acute exercise-related increase in collagen synthesis. Finally, the mechanical strength of isolated tendon collagen fascicles in men surpassed that of women. Thus, compared to men, women have (i) an attenuated tendon hypertrophy response to habitual training; (ii) a lower tendon collagen synthesis rate following acute exercise; (iii) a rate of tendon collagen synthesis which is further attenuated with elevated estradiol levels; and (iv) a lower mechanical strength of their tendons. These data indicate that tendons in women have a lower rate of new connective tissue formation, respond less to mechanical loading, and have a lower mechanical strength, which may leave the tissue more susceptible to injury.

AB - The reason why women sustain more soft tissue injury than men during physical activity is unknown. Connective tissue properties and extracellular matrix adaptability in human tendon were investigated in models that addressed biochemical, physiological and biomechanical aspects of tendon connective tissue in response to mechanical loading. Habitual training resulted in a larger patellar tendon in men but not in women. Following an acute bout of exercise, men had an elevated tendon collagen synthesis rate and this effect was less pronounced or absent in women. Moreover, levels of circulating oestrogen affected the acute exercise-related increase in collagen synthesis. Finally, the mechanical strength of isolated tendon collagen fascicles in men surpassed that of women. Thus, compared to men, women have (i) an attenuated tendon hypertrophy response to habitual training; (ii) a lower tendon collagen synthesis rate following acute exercise; (iii) a rate of tendon collagen synthesis which is further attenuated with elevated estradiol levels; and (iv) a lower mechanical strength of their tendons. These data indicate that tendons in women have a lower rate of new connective tissue formation, respond less to mechanical loading, and have a lower mechanical strength, which may leave the tissue more susceptible to injury.

KW - Adaptation, Physiological

KW - Collagen

KW - Exercise

KW - Female

KW - Humans

KW - Male

KW - Sex Characteristics

KW - Stress, Mechanical

KW - Tendons

KW - Weight-Bearing

U2 - 10.1111/j.1365-2613.2007.00551.x

DO - 10.1111/j.1365-2613.2007.00551.x

M3 - Journal article

C2 - 17696904

VL - 88

SP - 237

EP - 240

JO - International Journal of Experimental Pathology

JF - International Journal of Experimental Pathology

SN - 0959-9673

IS - 4

ER -

ID: 38365537