The influence of female and male body mass index on live births after assisted reproductive technology treatment: a nationwide register-based cohort study
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The influence of female and male body mass index on live births after assisted reproductive technology treatment : a nationwide register-based cohort study. / Petersen, Gitte Lindved; Schmidt, Lone; Pinborg, Anja; Kamper-Jørgensen, Mads.
In: Fertility and Sterility, Vol. 99, 05.02.2013, p. 1654–1662.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The influence of female and male body mass index on live births after assisted reproductive technology treatment
T2 - a nationwide register-based cohort study
AU - Petersen, Gitte Lindved
AU - Schmidt, Lone
AU - Pinborg, Anja
AU - Kamper-Jørgensen, Mads
N1 - Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
PY - 2013/2/5
Y1 - 2013/2/5
N2 - OBJECTIVE: To investigate the independent and combined associations between female and male body mass index (BMI) on the probability of achieving a live birth after treatments with in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) under adjustment for relevant covariates. DESIGN: Population-based cohort study. SETTING: Danish national registers. PATIENT(S): Patients with permanent residence in Denmark receiving IVF or ICSI treatment with use of autologous oocytes from January 1, 2006, to September 30, 2010. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live birth. Analyses were adjusted for age and smoking at treatment initiation and results stratified by BMI groups and presented by IVF/ICSI treatment. RESULT(S): In total, 12,566 women and their partners went through 25,191 IVF/ICSI cycles with 23.7% ending in a live birth. Overweight and obese women with regular ovulation had reduced odds of live birth (adjusted OR 0.88, 95% CI 0.79-0.99 and adjusted OR 0.75, 95% CI 0.63-0.90, respectively) compared with normal-weight women. IVF-treated couples with both partners having BMI =25 kg/m(2) had the lowest odds of live birth (adjusted OR 0.73, 95% CI 0.48-1.11) compared with couples with BMI
AB - OBJECTIVE: To investigate the independent and combined associations between female and male body mass index (BMI) on the probability of achieving a live birth after treatments with in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) under adjustment for relevant covariates. DESIGN: Population-based cohort study. SETTING: Danish national registers. PATIENT(S): Patients with permanent residence in Denmark receiving IVF or ICSI treatment with use of autologous oocytes from January 1, 2006, to September 30, 2010. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live birth. Analyses were adjusted for age and smoking at treatment initiation and results stratified by BMI groups and presented by IVF/ICSI treatment. RESULT(S): In total, 12,566 women and their partners went through 25,191 IVF/ICSI cycles with 23.7% ending in a live birth. Overweight and obese women with regular ovulation had reduced odds of live birth (adjusted OR 0.88, 95% CI 0.79-0.99 and adjusted OR 0.75, 95% CI 0.63-0.90, respectively) compared with normal-weight women. IVF-treated couples with both partners having BMI =25 kg/m(2) had the lowest odds of live birth (adjusted OR 0.73, 95% CI 0.48-1.11) compared with couples with BMI
U2 - 10.1016/j.fertnstert.2013.01.092
DO - 10.1016/j.fertnstert.2013.01.092
M3 - Journal article
C2 - 23394781
VL - 99
SP - 1654
EP - 1662
JO - Sexuality, Reproduction and Menopause
JF - Sexuality, Reproduction and Menopause
SN - 1546-2501
ER -
ID: 44780418