TMEM106B and ApoE polymorphisms in CHMP2B-mediated frontotemporal dementia (FTD-3)
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TMEM106B and ApoE polymorphisms in CHMP2B-mediated frontotemporal dementia (FTD-3). / Rostgaard, Nina; Roos, Peter; Budtz-Jørgensen, Esben; Johannsen, Peter; Waldemar, Gunhild; Nørremølle, Anne; Lindquist, Suzanne G.; Gydesen, Susanne; Brown, Jeremy M.; Collinge, John; Isaacs, Adrian M.; Nielsen, Troels T.; Nielsen, Jørgen E; FReJA collaboration.
In: Neurobiology of Aging, Vol. 59, 11.2017, p. 221.e1-221.e7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - TMEM106B and ApoE polymorphisms in CHMP2B-mediated frontotemporal dementia (FTD-3)
AU - Rostgaard, Nina
AU - Roos, Peter
AU - Budtz-Jørgensen, Esben
AU - Johannsen, Peter
AU - Waldemar, Gunhild
AU - Nørremølle, Anne
AU - Lindquist, Suzanne G.
AU - Gydesen, Susanne
AU - Brown, Jeremy M.
AU - Collinge, John
AU - Isaacs, Adrian M.
AU - Nielsen, Troels T.
AU - Nielsen, Jørgen E
AU - FReJA collaboration
N1 - Copyright © 2017 Elsevier Inc. All rights reserved.
PY - 2017/11
Y1 - 2017/11
N2 - Single-nucleotide polymorphisms in the TMEM106B gene have been identified as a risk factor in frontotemporal dementia (FTD). The major allele of SNP rs3173615 is a risk factor in sporadic FTD, whereas the minor allele seems protective in GRN- and C9orf72-mediated FTD. The role of apolipoprotein E (ApoE) in FTD is uncertain, though an established risk factor in Alzheimer's disease. In a unique Danish family, inherited FTD is caused by a mutation in the CHMP2B gene located on chromosome 3 (FTD-3). In this family, both risk factors TMEM106B and ApoE were analyzed and correlated to age at onset (AAO) and progression in terms of age at institutionalization (AAI) and age at death (AAD). Although TMEM106B and CHMP2B share cellular function in that both localize to endolysosomes, TMEM106B genotypes appeared to have no influence on the clinical disease course. ApoE ε4 was found to be a protective factor with later AAO and AAI, whereas ε2 seemed to aggravate the disease with earlier AAO and AAD. These results indicate ApoE ε2 as a risk factor in FTD-3 and suggest a protective role of ε4.
AB - Single-nucleotide polymorphisms in the TMEM106B gene have been identified as a risk factor in frontotemporal dementia (FTD). The major allele of SNP rs3173615 is a risk factor in sporadic FTD, whereas the minor allele seems protective in GRN- and C9orf72-mediated FTD. The role of apolipoprotein E (ApoE) in FTD is uncertain, though an established risk factor in Alzheimer's disease. In a unique Danish family, inherited FTD is caused by a mutation in the CHMP2B gene located on chromosome 3 (FTD-3). In this family, both risk factors TMEM106B and ApoE were analyzed and correlated to age at onset (AAO) and progression in terms of age at institutionalization (AAI) and age at death (AAD). Although TMEM106B and CHMP2B share cellular function in that both localize to endolysosomes, TMEM106B genotypes appeared to have no influence on the clinical disease course. ApoE ε4 was found to be a protective factor with later AAO and AAI, whereas ε2 seemed to aggravate the disease with earlier AAO and AAD. These results indicate ApoE ε2 as a risk factor in FTD-3 and suggest a protective role of ε4.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Apolipoprotein E2
KW - Disease Progression
KW - Endosomal Sorting Complexes Required for Transport
KW - Female
KW - Frontotemporal Dementia
KW - Genetic Association Studies
KW - Genetic Predisposition to Disease
KW - Humans
KW - Male
KW - Membrane Proteins
KW - Middle Aged
KW - Mutation
KW - Nerve Tissue Proteins
KW - Polymorphism, Single Nucleotide
KW - Risk Factors
KW - Journal Article
U2 - 10.1016/j.neurobiolaging.2017.06.026
DO - 10.1016/j.neurobiolaging.2017.06.026
M3 - Journal article
C2 - 28888721
VL - 59
SP - 221.e1-221.e7
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -
ID: 189155484