Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort
Research output: Contribution to journal › Journal article › Research › peer-review
Documents
- Fulltext
Final published version, 742 KB, PDF document
OBJECTIVE: To evaluate the use of cryopreserved ovarian tissue in the Danish fertility preservation cohort.
DESIGN: Retrospective cohort study.
SETTING: University hospitals and fertility clinics.
PATIENT(S): Ovarian tissue cryopreservation (OTC) was performed for 1,186 Danish girls and women from 1999-2020, of whom 117 subsequently underwent ovarian tissue transplantation (OTT). Subgroup 1 included 759 patients with a follow-up period of >5 years. Out of these, OTT rates were further analyzed for those patients who were alive and aged >24 years in July 2020 (subgroup 2; n = 554).
INTERVENTION(S): OTC and OTT.
MAIN OUTCOME MEASURE(S): OTT, death, donation of tissue.
RESULT(S): In subgroup 1, 14% of the patients had undergone OTT, 18% had died, 9% had donated their tissue for research, and 59% still had their tissue stored. In subgroup 2, 19% had undergone OTT and for most diagnoses the OTT rates ranged from 15% to 22% with benign hematologic diseases having the highest OTT rate (35%). On the basis of the entire cohort, stratified age analysis indicated that women aged ≥30 years at OTC were more likely to return for OTT than women aged 18-29 years at OTC; mean storage times were 3.7 and 3.6 years, respectively. Only 4% of the girls aged <18 years at OTC had undergone OTT.
CONCLUSION(S): The OTT rates depended on the diagnosis, age at OTC, and follow-up time. Specific criteria are needed for reporting and comparing OTT rates. Six out of 10 patients still had their cryopreserved tissue stored and longer follow-up is needed, especially for younger girls.
Original language | English |
---|---|
Journal | Fertility and Sterility |
Volume | 116 |
Issue number | 4 |
Pages (from-to) | 1098-1106 |
Number of pages | 9 |
ISSN | 0015-0282 |
DOIs | |
Publication status | Published - 2021 |
Bibliographical note
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
- Adolescent, Adult, Cryopreservation/trends, Denmark, Female, Fertility, Fertility Preservation, Humans, Infertility, Female/diagnosis, Organ Transplantation/trends, Ovary/transplantation, Pregnancy, Primary Ovarian Insufficiency/etiology, Retrospective Studies, Risk Factors, Time Factors, Young Adult
Research areas
ID: 288856662