Validation of registration of pharmacological treatment in the Danish Hip and Knee Arthroplasty Registers

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  • Astrid Blicher Schelde
  • Petersen, Janne
  • Thomas Bo Jensen
  • Kirill Gromov
  • Søren Overgaard
  • Jonas Bjerring Olesen
  • Espen Jimenez-Solem

The aim of this study was to validate registration of pharmacological treatment in the Danish Hip Arthroplasty Register (DHR) and Danish Knee Arthroplasty Register (DKR). We conducted a population-based study in the Capital Region of Denmark, January 2012 to April 2016. Positive predictive value (PPV) and sensitivity were calculated with 95% confidence intervals (CI) for antithrombotic, antihemorrhagic and antibiotic treatment registered in the DHR and DKR using electronic health records as the reference standard. For the DHR, the PPV and sensitivity were 77.9% (95% CI: 77.2-78.6) and 99.6% (95% CI: 99.4-99.7) for antithrombotic treatment, 70.9% (95% CI: 70.1-71.7) and 97.4% (95% CI: 97.1-97.7) for antihemorrhagic treatment, and 82.9% (95% CI: 82.2-83.5) and 99.4% (95% CI: 99.3-99.5) for antibiotic treatment, respectively. For the DKR, the PPV and sensitivity were 80.6% (95% CI: 79.8-81.4) and 99.6% (95% CI: 99.4-99.7) for antithrombotic treatment, and 84.4% (95% CI: 83.7-85.1) and 100.0% (95% CI: 99.9-100.0) for antibiotic treatment, respectively. The PPV and sensitivity for overall pharmacological treatment registered in the DHR and DKR were generally high and acceptable for use in research.

Original languageEnglish
JournalBasic & Clinical Pharmacology & Toxicology
Volume128
Issue number3
Pages (from-to)455-462
Number of pages8
ISSN1742-7835
DOIs
Publication statusPublished - 2021

    Research areas

  • clinical registers, drug use, electronic health record data, pharmacoepidemiology, validation study, VENOUS THROMBOEMBOLISM, REPLACEMENT, THROMBOPROPHYLAXIS, SYSTEM

ID: 251685332