Whole blood long-chain n-3 fatty acids as a measure of fish oil compliance in children with acute lymphoblastic leukemia: a pilot study
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Whole blood long-chain n-3 fatty acids as a measure of fish oil compliance in children with acute lymphoblastic leukemia: a pilot study. / Laumann, Renate D; Iversen, T; Frandsen, Thomas Leth; Mølgaard, Christian; Stark, K D; Schmiegelow, K; Lauritzen, Lotte.
In: Prostaglandins, Leukotrienes & Essential Fatty Acids, Vol. 177, 102401, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Whole blood long-chain n-3 fatty acids as a measure of fish oil compliance in children with acute lymphoblastic leukemia: a pilot study
AU - Laumann, Renate D
AU - Iversen, T
AU - Frandsen, Thomas Leth
AU - Mølgaard, Christian
AU - Stark, K D
AU - Schmiegelow, K
AU - Lauritzen, Lotte
N1 - Copyright © 2022. Published by Elsevier Ltd.
PY - 2022
Y1 - 2022
N2 - Long-chain n-3 fatty acids (n-3 LCPUFA) may prevent chemotherapy-induced hyperlipidemia in children with acute lymphoblastic leukemia (ALL). However, compliance could be a problem and intake-biomarker correlations may be affected by bodyweight and blood transfusions. We assessed whole blood n-3 LCPUFA three times during the first 83 days of treatment in six 1-17-year-old children with ALL, who received 2.4-4.9 g/d n-3 LCPUFA depending on bodyweight. Mean compliance was 73%, which resulted in a 2.5-fold increase in blood n-3 LCPUFA irrespective of blood transfusions. The correlation between relative blood content of n-3 LCPUFA and intake in g/d across the study period was strong (r=0.76, p=0.001). When n-3 LCPUFA was expressed in absolute concentrations and intake per kg bodyweight the correlation decreased (r=0.39, p=0.164) and was driven by baseline values. Thus, relative content of n-3 LCPUFA in blood reflects fish oil compliance in children with ALL despite blood transfusions and differences in bodyweight.
AB - Long-chain n-3 fatty acids (n-3 LCPUFA) may prevent chemotherapy-induced hyperlipidemia in children with acute lymphoblastic leukemia (ALL). However, compliance could be a problem and intake-biomarker correlations may be affected by bodyweight and blood transfusions. We assessed whole blood n-3 LCPUFA three times during the first 83 days of treatment in six 1-17-year-old children with ALL, who received 2.4-4.9 g/d n-3 LCPUFA depending on bodyweight. Mean compliance was 73%, which resulted in a 2.5-fold increase in blood n-3 LCPUFA irrespective of blood transfusions. The correlation between relative blood content of n-3 LCPUFA and intake in g/d across the study period was strong (r=0.76, p=0.001). When n-3 LCPUFA was expressed in absolute concentrations and intake per kg bodyweight the correlation decreased (r=0.39, p=0.164) and was driven by baseline values. Thus, relative content of n-3 LCPUFA in blood reflects fish oil compliance in children with ALL despite blood transfusions and differences in bodyweight.
KW - Faculty of Science
KW - Omega-3 fatty acids
KW - Dose-response-relationship
KW - Dietary biomarkers
KW - Cancer
KW - Acute lymphoblastic leukemia
KW - Children
U2 - 10.1016/j.plefa.2022.102401
DO - 10.1016/j.plefa.2022.102401
M3 - Journal article
C2 - 35085895
VL - 177
JO - Prostaglandins, Leukotrienes & Essential Fatty Acids
JF - Prostaglandins, Leukotrienes & Essential Fatty Acids
SN - 0952-3278
M1 - 102401
ER -
ID: 291017487