Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals. / Akintola, Abimbola A; Noordam, Raymond; Jansen, Steffy W; de Craen, Anton J; Ballieux, Bart E; Cobbaert, Christa M; Mooijaart, Simon P; Pijl, Hanno; Westendorp, Rudi G; van Heemst, Diana.

In: PloS one, Vol. 10, No. 10, e0139973, 07.10.2015, p. 1-13.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Akintola, AA, Noordam, R, Jansen, SW, de Craen, AJ, Ballieux, BE, Cobbaert, CM, Mooijaart, SP, Pijl, H, Westendorp, RG & van Heemst, D 2015, 'Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals', PloS one, vol. 10, no. 10, e0139973, pp. 1-13. https://doi.org/10.1371/journal.pone.0139973

APA

Akintola, A. A., Noordam, R., Jansen, S. W., de Craen, A. J., Ballieux, B. E., Cobbaert, C. M., ... van Heemst, D. (2015). Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals. PloS one, 10(10), 1-13. [e0139973]. https://doi.org/10.1371/journal.pone.0139973

Vancouver

Akintola AA, Noordam R, Jansen SW, de Craen AJ, Ballieux BE, Cobbaert CM et al. Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals. PloS one. 2015 Oct 7;10(10):1-13. e0139973. https://doi.org/10.1371/journal.pone.0139973

Author

Akintola, Abimbola A ; Noordam, Raymond ; Jansen, Steffy W ; de Craen, Anton J ; Ballieux, Bart E ; Cobbaert, Christa M ; Mooijaart, Simon P ; Pijl, Hanno ; Westendorp, Rudi G ; van Heemst, Diana. / Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals. In: PloS one. 2015 ; Vol. 10, No. 10. pp. 1-13.

Bibtex

@article{ab36cb1a139347848137d1e4d6f6bccf,
title = "Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals",
abstract = "BACKGROUND: The validity of continuous glucose monitoring (CGM) is well established in diabetic patients. CGM is also increasingly used for research purposes in normo-glycemic individuals, but the CGM validity in such individuals is unknown. We studied the accuracy of CGM measurements in normo-glycemic individuals by comparing CGM-derived versus venous blood-derived glucose levels and measures of glycemia and glycemic variability.METHODS: In 34 healthy participants (mean age 65.7 years), glucose was simultaneously measured every 10 minutes, via both an Enlite{\circledR} CGM sensor, and in venous blood sampled over a 24-hour period. Validity of CGM-derived individual glucose measurements, calculated measures of glycemia over daytime (09:00h-23:00h) and nighttime (23:00h-09:00h), and calculated measures of glycemic variability (e.g. 24h standard deviation [SD]) were assessed by Pearson correlation coefficients, mean absolute relative difference (MARD) and paired t-tests.RESULTS: The median correlation coefficient between CGM and venous glucose measurements per participant was 0.68 (interquartile range: 0.40-0.78), and the MARD was 17.6{\%} (SD = 17{\%}). Compared with venous sampling, the calculated measure of glycemia during daytime was 0.22 mmol/L higher when derived from CGM, but no difference was observed during nighttime. Most measures of glycemic variability were lower with CGM than with venous blood sampling (e.g., 24h SD: 1.07 with CGM and 1.26 with venous blood; p-value = 0.004).CONCLUSION: In normo-glycemic individuals, CGM-derived glucose measurements had good agreement with venous glucose levels. However, the measure of glycemia was higher during the day and most measures of glycemic variability were lower when derived from CGM.",
author = "Akintola, {Abimbola A} and Raymond Noordam and Jansen, {Steffy W} and {de Craen}, {Anton J} and Ballieux, {Bart E} and Cobbaert, {Christa M} and Mooijaart, {Simon P} and Hanno Pijl and Westendorp, {Rudi G} and {van Heemst}, Diana",
year = "2015",
month = "10",
day = "7",
doi = "10.1371/journal.pone.0139973",
language = "English",
volume = "10",
pages = "1--13",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

RIS

TY - JOUR

T1 - Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals

AU - Akintola, Abimbola A

AU - Noordam, Raymond

AU - Jansen, Steffy W

AU - de Craen, Anton J

AU - Ballieux, Bart E

AU - Cobbaert, Christa M

AU - Mooijaart, Simon P

AU - Pijl, Hanno

AU - Westendorp, Rudi G

AU - van Heemst, Diana

PY - 2015/10/7

Y1 - 2015/10/7

N2 - BACKGROUND: The validity of continuous glucose monitoring (CGM) is well established in diabetic patients. CGM is also increasingly used for research purposes in normo-glycemic individuals, but the CGM validity in such individuals is unknown. We studied the accuracy of CGM measurements in normo-glycemic individuals by comparing CGM-derived versus venous blood-derived glucose levels and measures of glycemia and glycemic variability.METHODS: In 34 healthy participants (mean age 65.7 years), glucose was simultaneously measured every 10 minutes, via both an Enlite® CGM sensor, and in venous blood sampled over a 24-hour period. Validity of CGM-derived individual glucose measurements, calculated measures of glycemia over daytime (09:00h-23:00h) and nighttime (23:00h-09:00h), and calculated measures of glycemic variability (e.g. 24h standard deviation [SD]) were assessed by Pearson correlation coefficients, mean absolute relative difference (MARD) and paired t-tests.RESULTS: The median correlation coefficient between CGM and venous glucose measurements per participant was 0.68 (interquartile range: 0.40-0.78), and the MARD was 17.6% (SD = 17%). Compared with venous sampling, the calculated measure of glycemia during daytime was 0.22 mmol/L higher when derived from CGM, but no difference was observed during nighttime. Most measures of glycemic variability were lower with CGM than with venous blood sampling (e.g., 24h SD: 1.07 with CGM and 1.26 with venous blood; p-value = 0.004).CONCLUSION: In normo-glycemic individuals, CGM-derived glucose measurements had good agreement with venous glucose levels. However, the measure of glycemia was higher during the day and most measures of glycemic variability were lower when derived from CGM.

AB - BACKGROUND: The validity of continuous glucose monitoring (CGM) is well established in diabetic patients. CGM is also increasingly used for research purposes in normo-glycemic individuals, but the CGM validity in such individuals is unknown. We studied the accuracy of CGM measurements in normo-glycemic individuals by comparing CGM-derived versus venous blood-derived glucose levels and measures of glycemia and glycemic variability.METHODS: In 34 healthy participants (mean age 65.7 years), glucose was simultaneously measured every 10 minutes, via both an Enlite® CGM sensor, and in venous blood sampled over a 24-hour period. Validity of CGM-derived individual glucose measurements, calculated measures of glycemia over daytime (09:00h-23:00h) and nighttime (23:00h-09:00h), and calculated measures of glycemic variability (e.g. 24h standard deviation [SD]) were assessed by Pearson correlation coefficients, mean absolute relative difference (MARD) and paired t-tests.RESULTS: The median correlation coefficient between CGM and venous glucose measurements per participant was 0.68 (interquartile range: 0.40-0.78), and the MARD was 17.6% (SD = 17%). Compared with venous sampling, the calculated measure of glycemia during daytime was 0.22 mmol/L higher when derived from CGM, but no difference was observed during nighttime. Most measures of glycemic variability were lower with CGM than with venous blood sampling (e.g., 24h SD: 1.07 with CGM and 1.26 with venous blood; p-value = 0.004).CONCLUSION: In normo-glycemic individuals, CGM-derived glucose measurements had good agreement with venous glucose levels. However, the measure of glycemia was higher during the day and most measures of glycemic variability were lower when derived from CGM.

U2 - 10.1371/journal.pone.0139973

DO - 10.1371/journal.pone.0139973

M3 - Journal article

C2 - 26445499

VL - 10

SP - 1

EP - 13

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 10

M1 - e0139973

ER -

ID: 146206966